Display options
Cite
Kang C, Jeong W, Park JS, et al. Comparison of Prognostic Performance between Neuron-Specific Enolase and S100 Calcium-Binding Protein B Obtained from the Cerebrospinal Fluid of Out-of-Hospital Cardiac Arrest Survivors Who Underwent Targeted Temperature Management. J Clin Med. 2021;10(7)doi: 10.3390/jcm10071531.
Kang, C., Jeong, W., Park, J. S., You, Y., Min, J. H., Cho, Y. C., & Ahn, H. J. (2021). Comparison of Prognostic Performance between Neuron-Specific Enolase and S100 Calcium-Binding Protein B Obtained from the Cerebrospinal Fluid of Out-of-Hospital Cardiac Arrest Survivors Who Underwent Targeted Temperature Management. Journal of clinical medicine, 10(7), . https://doi.org/10.3390/jcm10071531
Kang, Changshin, et al. "Comparison of Prognostic Performance between Neuron-Specific Enolase and S100 Calcium-Binding Protein B Obtained from the Cerebrospinal Fluid of Out-of-Hospital Cardiac Arrest Survivors Who Underwent Targeted Temperature Management." Journal of clinical medicine vol. 10,7 (2021). doi: https://doi.org/10.3390/jcm10071531
Kang C, Jeong W, Park JS, You Y, Min JH, Cho YC, Ahn HJ. Comparison of Prognostic Performance between Neuron-Specific Enolase and S100 Calcium-Binding Protein B Obtained from the Cerebrospinal Fluid of Out-of-Hospital Cardiac Arrest Survivors Who Underwent Targeted Temperature Management. J Clin Med. 2021 Apr 06;10(7). doi: 10.3390/jcm10071531. PMID: 33917473; PMCID: PMC8038742.
Copy Download .nbib Format: NLM
Share it on

J Clin Med. 2021 Apr 06;10(7). doi: 10.3390/jcm10071531.

Comparison of Prognostic Performance between Neuron-Specific Enolase and S100 Calcium-Binding Protein B Obtained from the Cerebrospinal Fluid of Out-of-Hospital Cardiac Arrest Survivors Who Underwent Targeted Temperature Management.

Journal of clinical medicine

Changshin Kang, Wonjoon Jeong, Jung Soo Park, Yeonho You, Jin Hong Min, Yong Chul Cho, Hong Joon Ahn

Affiliations

  1. Department of Emergency Medicine, Chungnam National University Hospital, 282, Munhwa-ro, Jung-gu, Daejeon 35015, Korea.
  2. Department of Emergency Medicine, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
  3. Department of Emergency Medicine, Chungnam National University Sejong Hospital, 20, Bodeum 7-ro, Sejong 30099, Korea.

PMID: 33917473 PMCID: PMC8038742 DOI: 10.3390/jcm10071531

Abstract

We compared the prognostic performances of serum neuron-specific enolase (sNSE), cerebrospinal fluid (CSF) NSE (cNSE), and CSF S100 calcium-binding protein B (cS100B) in out-of-hospital cardiac arrest (OHCA) survivors. This prospective observational study enrolled 45 patients. All samples were obtained immediately and at 24 h intervals until 72 h after the return of spontaneous circulation. The inter- and intragroup differences in biomarker levels, categorized by 3 month neurological outcome, were analyzed. The prognostic performances were evaluated with receiver operating characteristic curves. Twenty-two patients (48.9%) showed poor outcome. At all-time points, sNSE, cNSE, and cS100B were significantly higher in the poor outcome group than in the good outcome group. cNSE and cS100B significantly increased over time (baseline vs. 24, 48, and 72 h) in the poor outcome group than in the good outcome group. sNSE at 24, 48, and 72 h showed significantly lower sensitivity than cNSE or cS100B. The sensitivities associated with 0 false-positive rate (FPR) for cNSE and cS100B were 66.6% vs. 45.5% at baseline, 80.0% vs. 80.0% at 24 h, 84.2% vs. 94.7% at 48 h, and 88.2% (FPR, 5.0%) vs. 94.1% at 72 h. High cNSE and cS100B are strong predictors of poor neurological outcome in OHCA survivors. Multicenter prospective studies may determine the generalizability of these results.

Keywords: S100 proteins; biomarkers; neuron-specific enolase; out-of-hospital cardiac arrest; phosphopyruvate hydratase; prognosis; targeted temperature management

References

  1. Resuscitation. 2014 Dec;85(12):1779-89 - PubMed
  2. Circulation. 2001 Jun 5;103(22):2694-8 - PubMed
  3. Crit Care. 2017 Jun 20;21(1):153 - PubMed
  4. Emerg Med J. 2008 Oct;25(10):666-9 - PubMed
  5. Circulation. 2019 Mar 5;139(10):e56-e528 - PubMed
  6. J Am Coll Cardiol. 2013 Aug 27;62(9):851-8 - PubMed
  7. Clin Biochem. 2008 Jul;41(10-11):755-63 - PubMed
  8. Crit Care. 2017 Apr 13;21(1):90 - PubMed
  9. Circulation. 2020 Oct 20;142(16_suppl_2):S366-S468 - PubMed
  10. Resuscitation. 2013 Oct;84(10):1382-6 - PubMed
  11. Am J Emerg Med. 2016 Aug;34(8):1583-8 - PubMed
  12. Resuscitation. 2010 May;81(5):530-3 - PubMed
  13. Resuscitation. 2018 Jan;122:79-86 - PubMed
  14. Circulation. 2015 Nov 3;132(18 Suppl 2):S465-82 - PubMed
  15. Stroke. 1996 Sep;27(9):1641-6; discussion 1647 - PubMed
  16. Curr Opin Cell Biol. 2015 Feb;32:121-30 - PubMed
  17. Circulation. 2019 Aug 27;140(9):e517-e542 - PubMed
  18. Medicine (Baltimore). 2019 Feb;98(6):e14496 - PubMed
  19. Resuscitation. 2019 Dec;145:185-191 - PubMed
  20. Resuscitation. 2018 Oct;131:42-47 - PubMed
  21. J Neurol Sci. 1993 May;116(1):100-9 - PubMed
  22. Rev Esp Cardiol (Engl Ed). 2020 Feb;73(2):123-130 - PubMed
  23. Resuscitation. 2015 Nov;96:46-52 - PubMed
  24. Emerg Med J. 2016 Oct;33(10):690-5 - PubMed
  25. Resuscitation. 2019 Jul;140:161-169 - PubMed
  26. Resuscitation. 2020 Nov;156:273-276 - PubMed
  27. Biometrics. 1988 Sep;44(3):837-45 - PubMed

Publication Types

Grant support