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Ayo A, Laakkonen P. Peptide-Based Strategies for Targeted Tumor Treatment and Imaging. Pharmaceutics. 2021;13(4)doi: 10.3390/pharmaceutics13040481.
Ayo, A., & Laakkonen, P. (2021). Peptide-Based Strategies for Targeted Tumor Treatment and Imaging. Pharmaceutics, 13(4), . https://doi.org/10.3390/pharmaceutics13040481
Ayo, Abiodun, and Laakkonen, Pirjo. "Peptide-Based Strategies for Targeted Tumor Treatment and Imaging." Pharmaceutics vol. 13,4 (2021). doi: https://doi.org/10.3390/pharmaceutics13040481
Ayo A, Laakkonen P. Peptide-Based Strategies for Targeted Tumor Treatment and Imaging. Pharmaceutics. 2021 Apr 02;13(4). doi: 10.3390/pharmaceutics13040481. PMID: 33918106; PMCID: PMC8065807.
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Pharmaceutics. 2021 Apr 02;13(4). doi: 10.3390/pharmaceutics13040481.

Peptide-Based Strategies for Targeted Tumor Treatment and Imaging.

Pharmaceutics

Abiodun Ayo, Pirjo Laakkonen

Affiliations

  1. Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
  2. Laboratory Animal Center, HiLIFE-Helsinki Institute of Life Science, University of Helsinki, 00014 Helsinki, Finland.

PMID: 33918106 PMCID: PMC8065807 DOI: 10.3390/pharmaceutics13040481

Abstract

Cancer is one of the leading causes of death worldwide. The development of cancer-specific diagnostic agents and anticancer toxins would improve patient survival. The current and standard types of medical care for cancer patients, including surgery, radiotherapy, and chemotherapy, are not able to treat all cancers. A new treatment strategy utilizing tumor targeting peptides to selectively deliver drugs or applicable active agents to solid tumors is becoming a promising approach. In this review, we discuss the different tumor-homing peptides discovered through combinatorial library screening, as well as native active peptides. The different structure-function relationship data that have been used to improve the peptide's activity and conjugation strategies are highlighted.

Keywords: drug delivery; targeted delivery; tumor homing peptides

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