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Guzik BM, McCallum L, Zmudka K, et al. Echocardiography Predictors of Survival in Hypertensive Patients With Left Ventricular Hypertrophy. Am J Hypertens. 2021;34(6):636-644doi: 10.1093/ajh/hpaa194.
Guzik, B. M., McCallum, L., Zmudka, K., Guzik, T. J., Dominiczak, A. F., & Padmanabhan, S. (2021). Echocardiography Predictors of Survival in Hypertensive Patients With Left Ventricular Hypertrophy. American journal of hypertension, 34(6), 636-644. https://doi.org/10.1093/ajh/hpaa194
Guzik, Bartlomiej M, et al. "Echocardiography Predictors of Survival in Hypertensive Patients With Left Ventricular Hypertrophy." American journal of hypertension vol. 34,6 (2021): 636-644. doi: https://doi.org/10.1093/ajh/hpaa194
Guzik BM, McCallum L, Zmudka K, Guzik TJ, Dominiczak AF, Padmanabhan S. Echocardiography Predictors of Survival in Hypertensive Patients With Left Ventricular Hypertrophy. Am J Hypertens. 2021 Jun 22;34(6):636-644. doi: 10.1093/ajh/hpaa194. PMID: 33950188.
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Am J Hypertens. 2021 Jun 22;34(6):636-644. doi: 10.1093/ajh/hpaa194.

Echocardiography Predictors of Survival in Hypertensive Patients With Left Ventricular Hypertrophy.

American journal of hypertension

Bartlomiej M Guzik, Linsay McCallum, Krzysztof Zmudka, Tomasz J Guzik, Anna F Dominiczak, Sandosh Padmanabhan

Affiliations

  1. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  2. Jagiellonian University Medical College, Institute of Cardiology, Department of Interventional Cardiology, John Paul II Hospital, Krakow, Poland.
  3. Department of Internal and Agricultural Medicine, Jagiellonian University Collegium Medicum, Krakow, Poland.

PMID: 33950188 DOI: 10.1093/ajh/hpaa194

Abstract

BACKGROUND: Left ventricular hypertrophy (LVH) is a well-known target organ damage. Concentric hypertrophy is the strongest predictor of increased risk of cardiovascular events, but the predictive value of individual echocardiographic parameters remains unclear.The aim of this study was to search for echocardiographic and hemodynamic variables associated with concentric and eccentric remodeling and their association with long-term cardiovascular outcomes.

METHODS: Patients with echocardiography performed within 1 year prior to the initial clinic visit were included into the study. Logistic regression and multivariable Cox-proportional hazards were calculated according to several risk factors and variables. Additionally, cubic spline interpolation was used.

RESULTS: We observed 690 patients for 10 years. There was a total of 177 major adverse cardiac and cerebrovascular events (MACCE) and 90 deaths over a 10-year period. Left ventricular concentric hypertrophy is associated with worse outcomes than eccentric hypertrophy in hypertensive subjects. Interestingly, different echocardiographic parameters contributed to risk depending on type of hypertrophy. In concentric hypertrophy, relative wall thickness provides linear prediction of risk for all-cause mortality (ACM) and composite endpoint. Systolic blood pressure is a significant predictor of MACCE. Blood pressure variability also showed significant predictive value for MACCE and ACM.

CONCLUSIONS: These data indicate risk stratification based on LVH need to consider different measures based on the type of remodeling.

© American Journal of Hypertension, Ltd 2021. All rights reserved. For Permissions, please email: [email protected].

Keywords: blood pressure; concentric remodeling; eccentric remodeling; hypertension; mortality; survival

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