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Pedro-Botet J, Climent E, Gabarró N, et al. Hiperlipemia familiar combinada/hiperlipemia mixta poligénica. Familial combined hyperlipidaemia/polygenic mixed hyperlipidaemia. Clin Investig Arterioscler. 2021;33:43-49doi: 10.1016/j.arteri.2020.12.013.
Pedro-Botet, J., Climent, E., Gabarró, N., & Millán, J. (2021). Hiperlipemia familiar combinada/hiperlipemia mixta poligénica. Familial combined hyperlipidaemia/polygenic mixed hyperlipidaemia. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis, 3343-49. https://doi.org/10.1016/j.arteri.2020.12.013
Pedro-Botet, Juan, et al. "Hiperlipemia familiar combinada/hiperlipemia mixta poligénica." Familial combined hyperlipidaemia/polygenic mixed hyperlipidaemia. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis vol. 33 (2021): 43-49. doi: https://doi.org/10.1016/j.arteri.2020.12.013
Pedro-Botet J, Climent E, Gabarró N, Millán J. Hiperlipemia familiar combinada/hiperlipemia mixta poligénica. Familial combined hyperlipidaemia/polygenic mixed hyperlipidaemia. Clin Investig Arterioscler. 2021 May;33:43-49. doi: 10.1016/j.arteri.2020.12.013. Spanish. PMID: 34006353.
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Clin Investig Arterioscler. 2021 May;33:43-49. doi: 10.1016/j.arteri.2020.12.013.

Familial combined hyperlipidaemia/polygenic mixed hyperlipidaemia.

Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis

[Article in Spanish]
Juan Pedro-Botet, Elisenda Climent, Nuria Gabarró, Jesús Millán

Affiliations

  1. Unidad de Lípidos y Riesgo Vascular, Hospital del Mar, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, España. Electronic address: [email protected].
  2. Unidad de Lípidos y Riesgo Vascular, Hospital del Mar, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, España.
  3. Unidad de Lípidos, Servicio de Medicina Interna, H. U. Gregorio Marañón, Universidad Complutense, Madrid, España.

PMID: 34006353 DOI: 10.1016/j.arteri.2020.12.013

Abstract

Familial combined hyperlipidaemia (FCH) is the most prevalent form of familial hyperlipidaemia with a multigenic origin and a complex pattern of inheritance. In this respect, FCH is an oligogenic primary lipid disorder due to interaction of genetic variants and mutations with environmental factors. Patients with FCH are at increased risk of cardiovascular disease and often have other associated metabolic conditions. Despite its relevance in cardiovascular prevention, FCH is frequently underdiagnosed and very often undertreated. In this review, emphasis is placed on the most recent advances in FCH, in order to increase its awareness and ultimately contribute to improving its clinical control.

Copyright © 2021 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.

Keywords: Dislipidemia; Dyslipidaemia; Familial combined hyperlipidaemia; Hipercolesterolemia; Hiperlipemia familiar combinada; Hipertrigliceridemia; Hypercholesterolaemia; Hypertriglyceridaemia

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