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García-Mendívil L, Mediano DR, Hernaiz A, et al. Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons. Animals (Basel). 2021;11(4)doi: 10.3390/ani11041137.
García-Mendívil, L., Mediano, D. R., Hernaiz, A., Sanz-Rubio, D., Vázquez, F. J., Marín, B., López-Pérez, �. �., Otero, A., Badiola, J. J., Zaragoza, P., Ordovás, L., Bolea, R., & Martín-Burriel, I. (2021). Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons. Animals : an open access journal from MDPI, 11(4), . https://doi.org/10.3390/ani11041137
García-Mendívil, Laura, et al. "Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons." Animals : an open access journal from MDPI vol. 11,4 (2021). doi: https://doi.org/10.3390/ani11041137
García-Mendívil L, Mediano DR, Hernaiz A, Sanz-Rubio D, Vázquez FJ, Marín B, López-Pérez Ó, Otero A, Badiola JJ, Zaragoza P, Ordovás L, Bolea R, Martín-Burriel I. Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons. Animals (Basel). 2021 Apr 15;11(4). doi: 10.3390/ani11041137. PMID: 33921147; PMCID: PMC8071557.
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Animals (Basel). 2021 Apr 15;11(4). doi: 10.3390/ani11041137.

Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons.

Animals : an open access journal from MDPI

Laura García-Mendívil, Diego R Mediano, Adelaida Hernaiz, David Sanz-Rubio, Francisco J Vázquez, Belén Marín, Óscar López-Pérez, Alicia Otero, Juan J Badiola, Pilar Zaragoza, Laura Ordovás, Rosa Bolea, Inmaculada Martín-Burriel

Affiliations

  1. Laboratorio de Genética Bioquímica (LAGENBIO), Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria de Aragón (IISAragón), Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain.
  2. Biomedical Signal Interpretation and Computational Simulation (BSICoS), Institute of Engineering Research (I3A), University of Zaragoza & Instituto de Investigación Sanitaria (IIS), 50018 Zaragoza, Spain.
  3. Translational Research Unit, Instituto de Investigación Sanitaria de Aragón (IISAragón), Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain.
  4. Departamento de Patología Animal, Facultad de Veterinaria, Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain.
  5. Centro de Investigación en Encefalopatías y Enfermedades Transmisibles Emergentes, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria de Aragón (IISAragón), Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain.
  6. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, 28031 Madrid, Spain.

PMID: 33921147 PMCID: PMC8071557 DOI: 10.3390/ani11041137

Abstract

Scrapie is a prion disease affecting sheep and goats and it is considered a prototype of transmissible spongiform encephalopathies (TSEs). Mesenchymal stem cells (MSCs) have been proposed as candidates for developing in vitro models of prion diseases. Murine MSCs are able to propagate prions after previous mouse-adaptation of prion strains and, although ovine MSCs express the cellular prion protein (PrP

Keywords: in vitro model; infection; mesenchymal stem cell; prion; scrapie; sheep

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