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Gilbert CJ, Longenecker JZ, Accornero F. ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth. Biology (Basel). 2021;10(4)doi: 10.3390/biology10040346.
Gilbert, C. J., Longenecker, J. Z., & Accornero, F. (2021). ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth. Biology, 10(4), . https://doi.org/10.3390/biology10040346
Gilbert, Christopher J, et al. "ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth." Biology vol. 10,4 (2021). doi: https://doi.org/10.3390/biology10040346
Gilbert CJ, Longenecker JZ, Accornero F. ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth. Biology (Basel). 2021 Apr 20;10(4). doi: 10.3390/biology10040346. PMID: 33923899; PMCID: PMC8072600.
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Biology (Basel). 2021 Apr 20;10(4). doi: 10.3390/biology10040346.

ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth.

Biology

Christopher J Gilbert, Jacob Z Longenecker, Federica Accornero

Affiliations

  1. Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.

PMID: 33923899 PMCID: PMC8072600 DOI: 10.3390/biology10040346

Abstract

Integration of cellular responses to extracellular cues is essential for cell survival and adaptation to stress. Extracellular signal-regulated kinase (ERK) 1 and 2 serve an evolutionarily conserved role for intracellular signal transduction that proved critical for cardiomyocyte homeostasis and cardiac stress responses. Considering the importance of ERK1/2 in the heart, understanding how these kinases operate in both normal and disease states is critical. Here, we review the complexity of upstream and downstream signals that govern ERK1/2-dependent regulation of cardiac structure and function. Particular emphasis is given to cardiomyocyte hypertrophy as an outcome of ERK1/2 activation regulation in the heart.

Keywords: ERK; cardiac hypertrophy; extracellular matrix; heart

References

  1. J Clin Invest. 2008 Dec;118(12):3870-80 - PubMed
  2. J Cell Biochem. 2008 Apr 15;103(6):1718-31 - PubMed
  3. Oncogene. 2004 Apr 29;23(20):3580-8 - PubMed
  4. Circ Res. 2002 May 3;90(8):850-7 - PubMed
  5. BMC Cancer. 2018 May 31;18(1):613 - PubMed
  6. Biochem Biophys Res Commun. 2005 Jul 22;333(1):110-5 - PubMed
  7. Mol Cell Biol. 1993 Feb;13(2):801-8 - PubMed
  8. Biochem Biophys Res Commun. 2010 Apr 9;394(3):691-6 - PubMed
  9. Cardiovasc Res. 2012 Nov 1;96(2):255-64 - PubMed
  10. J Proteomics. 2010 Mar 10;73(5):992-1003 - PubMed
  11. Cardiovasc Res. 2015 May 1;106(2):261-71 - PubMed
  12. Basic Res Cardiol. 2016 Jul;111(4):47 - PubMed
  13. Dev Biol. 2018 Dec 1;444 Suppl 1:S79-S97 - PubMed
  14. Circulation. 2020 Dec;142(22):2138-2154 - PubMed
  15. J Cell Physiol. 2016 Jul;231(7):1562-74 - PubMed
  16. J Biol Chem. 2003 Oct 24;278(43):42214-24 - PubMed
  17. Sci Signal. 2017 Apr 18;10(475): - PubMed
  18. JAMA Netw Open. 2019 Aug 2;2(8):e198890 - PubMed
  19. Mol Cell Proteomics. 2017 Apr;16(4):663-679 - PubMed
  20. Circ Res. 1998 Sep 21;83(6):594-601 - PubMed
  21. Circ Res. 2016 Jul 8;119(2):249-60 - PubMed
  22. Int J Cardiol. 2018 Nov 1;270:204-213 - PubMed
  23. N Engl J Med. 2019 Aug 15;381(7):626-636 - PubMed
  24. Am J Physiol Heart Circ Physiol. 2020 Feb 1;318(2):H238-H251 - PubMed
  25. Circ Res. 2008 Oct 24;103(9):992-1000 - PubMed
  26. Int J Mol Sci. 2019 Mar 17;20(6): - PubMed
  27. Mol Cell Biol. 2006 Jul;26(14):5481-96 - PubMed
  28. J Mol Cell Cardiol. 2007 Aug;43(2):137-47 - PubMed
  29. PLoS One. 2017 Sep 14;12(9):e0184861 - PubMed
  30. Nat Med. 2009 Jan;15(1):75-83 - PubMed
  31. J Cell Mol Med. 2014 Nov;18(11):2311-20 - PubMed
  32. Hum Mutat. 2009 Apr;30(4):695-702 - PubMed
  33. Mol Cell. 2008 Sep 5;31(5):708-21 - PubMed
  34. Clin Exp Pharmacol Physiol. 2009 Nov;36(11):1054-61 - PubMed
  35. J Cell Sci. 2006 Aug 1;119(Pt 15):3021-3 - PubMed
  36. Nature. 2010 Jun 10;465(7299):808-12 - PubMed
  37. Sci Signal. 2018 Oct 30;11(554): - PubMed
  38. Sci Signal. 2011 Oct 25;4(196):rs11 - PubMed
  39. Basic Res Cardiol. 2019 Jan 11;114(2):7 - PubMed
  40. Physiol Rev. 2001 Jan;81(1):153-208 - PubMed
  41. Biochem Biophys Res Commun. 2002 Mar 8;291(4):995-1000 - PubMed
  42. Mol Cancer Res. 2006 Dec;4(12):945-55 - PubMed
  43. Int J Mol Sci. 2020 Jul 24;21(15): - PubMed
  44. Chin Med J (Engl). 2008 Feb 5;121(3):236-40 - PubMed
  45. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):340-345 - PubMed
  46. Cell Signal. 2004 Jul;16(7):769-79 - PubMed
  47. Cell Cycle. 2009 Apr 15;8(8):1168-75 - PubMed
  48. Nature. 1982 Feb 4;295(5848):419-20 - PubMed
  49. Exp Neurobiol. 2020 Jun 30;29(3):189-206 - PubMed
  50. J Mol Cell Cardiol. 2002 Feb;34(2):139-50 - PubMed
  51. EMBO J. 2003 Oct 15;22(20):5491-500 - PubMed
  52. Trends Pharmacol Sci. 2007 Dec;28(12):602-7 - PubMed
  53. Circulation. 2004 Aug 10;110(6):718-23 - PubMed
  54. Nucleic Acids Res. 2012 Jan;40(Database issue):D261-70 - PubMed
  55. Am J Physiol Cell Physiol. 2002 Apr;282(4):C926-34 - PubMed
  56. Curr Opin Cell Biol. 1999 Jun;11(3):363-71 - PubMed
  57. J Biol Chem. 2001 Oct 19;276(42):38449-56 - PubMed
  58. J Mol Cell Cardiol. 2019 Feb;127:67-73 - PubMed
  59. J Mol Cell Cardiol. 2004 Apr;36(4):481-93 - PubMed
  60. Nature. 2004 Nov 25;432(7016):522-5 - PubMed
  61. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12331-6 - PubMed
  62. FEBS Lett. 2017 Sep;591(17):2607-2615 - PubMed
  63. Mol Cell Biol. 2004 Mar;24(6):2499-512 - PubMed
  64. Eur J Heart Fail. 2007 Jun-Jul;9(6-7):568-73 - PubMed
  65. Nat Rev Mol Cell Biol. 2014 Dec;15(12):786-801 - PubMed
  66. J Biol Chem. 2006 Mar 10;281(10):6236-45 - PubMed
  67. J Clin Invest. 2007 Sep;117(9):2445-58 - PubMed
  68. J Am Heart Assoc. 2021 Feb 16;10(4):e014311 - PubMed
  69. Cancer Res. 2017 May 1;77(9):2328-2338 - PubMed
  70. Mol Cell Biochem. 2001 Jul;223(1-2):35-46 - PubMed
  71. J Mol Cell Cardiol. 2019 Feb;127:31-43 - PubMed
  72. J Biol Chem. 2008 Mar 7;283(10):6312-20 - PubMed
  73. Hypertens Res. 1999 Jul;22(2):113-9 - PubMed
  74. J Cell Biochem. 2014 Apr;115(4):712-20 - PubMed
  75. EMBO J. 2000 Dec 1;19(23):6341-50 - PubMed
  76. Lancet Oncol. 2016 Sep;17(9):1248-60 - PubMed
  77. Basic Res Cardiol. 2000;95 Suppl 1:I8-14 - PubMed
  78. Front Physiol. 2012 Sep 18;3:355 - PubMed
  79. J Biol Chem. 2004 Jun 4;279(23):24852-60 - PubMed
  80. Nature. 2002 Jun 27;417(6892):949-54 - PubMed
  81. Mol Cell Proteomics. 2009 Dec;8(12):2796-808 - PubMed
  82. Cardiovasc Res. 2006 Jun 1;70(3):422-33 - PubMed
  83. Cell Signal. 2006 Oct;18(10):1655-63 - PubMed
  84. Biochem Biophys Res Commun. 2001 Apr 27;283(1):143-8 - PubMed
  85. Int J Cardiol. 2013 Aug 20;167(4):1570-7 - PubMed
  86. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9806-11 - PubMed
  87. Front Cell Dev Biol. 2021 Feb 26;9:642840 - PubMed
  88. Circulation. 2004 Apr 27;109(16):1938-41 - PubMed
  89. Hum Mutat. 2014 Nov;35(11):1290-4 - PubMed
  90. Nat Commun. 2020 Apr 7;11(1):1733 - PubMed
  91. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5902-7 - PubMed
  92. Oncotarget. 2015 Nov 3;6(34):35589-601 - PubMed
  93. J Clin Invest. 1994 Jul;94(1):301-10 - PubMed
  94. Free Radic Biol Med. 2011 Aug 1;51(3):609-18 - PubMed
  95. Mol Biol Cell. 1997 Oct;8(10):2003-15 - PubMed
  96. J Biol Chem. 1999 Apr 2;274(14):9760-70 - PubMed
  97. Circ Res. 2001 Jan 19;88(1):88-96 - PubMed
  98. Curr Opin Genet Dev. 1994 Feb;4(1):82-9 - PubMed
  99. J Cell Biol. 1993 Feb;120(3):625-30 - PubMed
  100. Mol Cell Proteomics. 2015 Jun;14(6):1599-615 - PubMed
  101. Pharmacol Res. 2019 Apr;142:151-168 - PubMed
  102. Small GTPases. 2013 Jul-Sep;4(3):180-5 - PubMed
  103. Dev Dyn. 2010 Jul;239(7):2005-13 - PubMed
  104. Nature. 2009 Sep 24;461(7263):542-5 - PubMed
  105. Nat Med. 2003 Jan;9(1):68-75 - PubMed
  106. Cell Res. 2002 Mar;12(1):9-18 - PubMed
  107. Circulation. 2008 Mar 18;117(11):1423-35 - PubMed
  108. Circ Res. 2005 May 27;96(10):1087-94 - PubMed
  109. Biochem Biophys Res Commun. 2021 Jan 1;534:53-58 - PubMed
  110. Nat Struct Mol Biol. 2009 Mar;16(3):294-303 - PubMed
  111. Cancer Res. 2019 Sep 1;79(17):4466-4479 - PubMed
  112. Lancet Oncol. 2018 May;19(5):603-615 - PubMed
  113. Cells. 2020 Aug 31;9(9): - PubMed
  114. J Cell Sci. 2011 Oct 15;124(Pt 20):3515-24 - PubMed
  115. Br J Cancer. 2010 Jun 8;102(12):1724-30 - PubMed
  116. J Clin Invest. 2011 Mar;121(3):1009-25 - PubMed
  117. Dev Biol. 1965 Dec;12(3):394-407 - PubMed
  118. Mol Cell Biol. 2008 Nov;28(22):6954-66 - PubMed
  119. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3444-9 - PubMed
  120. Dev Dyn. 2008 Jan;237(1):163-9 - PubMed
  121. Circulation. 1993 Apr;87(4):1328-39 - PubMed
  122. Circ Res. 2011 Jan 21;108(2):176-83 - PubMed
  123. Mol Cell. 2015 Apr 2;58(1):35-46 - PubMed
  124. Biochim Biophys Acta Proteins Proteom. 2017 Jan;1865(1):1-10 - PubMed
  125. J Biochem Mol Biol. 2007 Nov 30;40(6):899-910 - PubMed
  126. J Mol Cell Cardiol. 2000 Aug;32(8):1447-57 - PubMed
  127. Nat Struct Mol Biol. 2009 Oct;16(10):1026-35 - PubMed
  128. J Mol Cell Cardiol. 2010 Nov;49(5):819-28 - PubMed
  129. Stem Cells Dev. 2015 Mar 15;24(6):686-700 - PubMed
  130. Mol Cell Proteomics. 2014 Nov;13(11):3199-210 - PubMed
  131. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14074-9 - PubMed
  132. Mol Cell Biol. 2001 Feb;21(4):1173-84 - PubMed
  133. Nat Cell Biol. 2008 Feb;10(2):138-48 - PubMed
  134. J Biol Chem. 2000 Jul 7;275(27):20355-60 - PubMed
  135. Cell. 2018 Feb 8;172(4):857-868.e15 - PubMed
  136. J Mol Cell Cardiol. 1998 Mar;30(3):485-94 - PubMed
  137. Annu Rev Genomics Hum Genet. 2013;14:355-69 - PubMed
  138. Nat Rev Mol Cell Biol. 2020 Oct;21(10):607-632 - PubMed
  139. Proteomics. 2016 Jul;16(14):1998-2004 - PubMed
  140. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7440-5 - PubMed
  141. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9793-4 - PubMed
  142. FASEB J. 1995 Jun;9(9):726-35 - PubMed
  143. Cell Signal. 2014 Jun;26(6):1226-34 - PubMed
  144. Carcinogenesis. 2004 Jul;25(7):1165-75 - PubMed
  145. J Biol Chem. 1996 Jul 26;271(30):18122-7 - PubMed
  146. EMBO J. 2002 Jul 15;21(14):3782-93 - PubMed
  147. Lasers Med Sci. 2019 Apr;34(3):473-478 - PubMed
  148. Circ Res. 2021 Mar 19;128(6):723-737 - PubMed
  149. Genes (Basel). 2013 Mar 26;4(2):101-33 - PubMed
  150. Circ Res. 2010 Jan 8;106(1):79-88 - PubMed
  151. Nature. 1982 Aug 12;298(5875):667-9 - PubMed
  152. Dis Model Mech. 2013 Jul;6(4):964-76 - PubMed
  153. Cardiovasc Res. 2011 Aug 1;91(3):456-64 - PubMed
  154. PLoS One. 2013 Apr 18;8(4):e61697 - PubMed
  155. J Cell Sci. 2010 Sep 15;123(Pt 18):3084-93 - PubMed
  156. Mol Cell Biol. 2000 Oct;20(19):7259-72 - PubMed
  157. J Biol Chem. 2001 Sep 14;276(37):34888-95 - PubMed
  158. J Biol Chem. 2000 Jul 14;275(28):21688-94 - PubMed

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