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Chi Y, Liu X, Chai J. A narrative review of changes in microvascular permeability after burn. Ann Transl Med. 2021;9(8):719doi: 10.21037/atm-21-1267.
Chi, Y., Liu, X., & Chai, J. (2021). A narrative review of changes in microvascular permeability after burn. Annals of translational medicine, 9(8), 719. https://doi.org/10.21037/atm-21-1267
Chi, Yunfei, et al. "A narrative review of changes in microvascular permeability after burn." Annals of translational medicine vol. 9,8 (2021): 719. doi: https://doi.org/10.21037/atm-21-1267
Chi Y, Liu X, Chai J. A narrative review of changes in microvascular permeability after burn. Ann Transl Med. 2021 Apr;9(8):719. doi: 10.21037/atm-21-1267. PMID: 33987417; PMCID: PMC8106041.
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Ann Transl Med. 2021 Apr;9(8):719. doi: 10.21037/atm-21-1267.

A narrative review of changes in microvascular permeability after burn.

Annals of translational medicine

Yunfei Chi, Xiangyu Liu, Jiake Chai

Affiliations

  1. Burn Institute, The Fourth Medical Center of the PLA General Hospital, Beijing, China.

PMID: 33987417 PMCID: PMC8106041 DOI: 10.21037/atm-21-1267

Abstract

OBJECTIVE: We aimed to review and discuss some of the latest research results related to post-burn pathophysiological changes and provide some clues for future study.

BACKGROUND: Burns are one of the most common and serious traumas and consist of a series of pathophysiological changes of thermal injury. Accompanied by thermal damage to skin and soft tissues, inflammatory mediators are released in large quantities. Changes in histamine, bradykinin, and cytokines such as vascular endothelial growth factor (VEGF), metabolic factors such as adenosine triphosphate (ATP), and activated neutrophils all affect the body's vascular permeability.

METHODS: We searched articles with subject words "microvascular permeability", "burn" "endothelium", and "endothelial barrier" in PubMed in English published from the beginning of database to Dec, 2020.

CONCLUSIONS: The essence of burn shock is the rapid and extensive fluid transfer in burn and non-burn tissue. After severe burns, the local and systemic vascular permeability increase, causing intravascular fluid extravasation, leading to a progressive decrease in effective circulation volume, an increase in systemic vascular resistance, a decrease in cardiac output, peripheral tissue edema, multiple organ failure, and even death. There are many cells, tissues, mediators and structures involved in the pathophysiological process of the damage to vascular permeability. Ulinastatin is a promising agent for this problem.

2021 Annals of Translational Medicine. All rights reserved.

Keywords: Burns; capillaries; endothelium; permeability

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-21-1267). The authors have no conflicts of interest to declare.

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