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Marcelli E, Cercenelli L, Bortolani B, et al. A Novel Non-Invasive Device for the Assessment of Central Venous Pressure in Hospital, Office and Home. Med Devices (Auckl). 2021;14:141-154doi: 10.2147/MDER.S307775.
Marcelli, E., Cercenelli, L., Bortolani, B., Marini, S., Arfilli, L., Capucci, A., & Plicchi, G. (2021). A Novel Non-Invasive Device for the Assessment of Central Venous Pressure in Hospital, Office and Home. Medical devices (Auckland, N.Z.), 14141-154. https://doi.org/10.2147/MDER.S307775
Marcelli, Emanuela, et al. "A Novel Non-Invasive Device for the Assessment of Central Venous Pressure in Hospital, Office and Home." Medical devices (Auckland, N.Z.) vol. 14 (2021): 141-154. doi: https://doi.org/10.2147/MDER.S307775
Marcelli E, Cercenelli L, Bortolani B, Marini S, Arfilli L, Capucci A, Plicchi G. A Novel Non-Invasive Device for the Assessment of Central Venous Pressure in Hospital, Office and Home. Med Devices (Auckl). 2021 May 13;14:141-154. doi: 10.2147/MDER.S307775. eCollection 2021. PMID: 34012302; PMCID: PMC8128499.
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Med Devices (Auckl). 2021 May 13;14:141-154. doi: 10.2147/MDER.S307775. eCollection 2021.

A Novel Non-Invasive Device for the Assessment of Central Venous Pressure in Hospital, Office and Home.

Medical devices (Auckland, N.Z.)

Emanuela Marcelli, Laura Cercenelli, Barbara Bortolani, Saverio Marini, Luca Arfilli, Alessandro Capucci, Gianni Plicchi

Affiliations

  1. eDIMES Lab-Laboratory of Bioengineering, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Bologna, Italy.
  2. Ars Medica: Associazione Medico-Chirurgica Della Gallura, Olbia, Italy.
  3. Villa Laura Ospedale Privato Accreditato, Bologna, Italy.
  4. Abcardio Cardiological Center, Bologna, Italy.
  5. TRE ESSE Progettazione Biomedica S.r.l., Bologna, 40138, Italy.

PMID: 34012302 PMCID: PMC8128499 DOI: 10.2147/MDER.S307775

Abstract

BACKGROUND: Venous congestion can be quantified by central venous pressure (CVP) and its monitoring is crucial to understand and follow the hemodynamic status of patients with cardio-respiratory diseases. The standard technique for CVP measurement is invasive, requiring the insertion of a catheter into a jugular vein, with potential complications. On the other hand, the current non-invasive methods, mainly based on ultrasounds, remain operator-dependent and are unsuitable for use in the home environment. In this paper, we will introduce a novel, non-invasive device for the hospital, office and home assessment of CVP.

METHODS: After describing the measurement concept, we will report a preliminary experimental study enrolling 5 voluntary healthy subjects to evaluate the VenCoM measurements' repeatability, and the system's capability in measuring small elicited venous pressure variations (2 mmHg), as well as an induced venous hypertension within a pathological range (12÷20 mmHg).

RESULTS: The experimental measurements showed a repeatability of ±1mmHg. The VenCoM device was able to reliably detect the elicited venous pressure variations and the simulated congestive status.

DISCUSSION AND CONCLUSION: The proposed non-invasive VenCoM device is able to provide a fast and repeatable CVP estimate, having a wide spectrum of potential clinical applications, including the monitoring of venous congestion in heart failure patients and in subjects with renal and hepatic dysfunction, as well as pulmonary hypertension (PH) that can be extended to pneumonia COVID-19 patients even after recovery. The device needs to be tested further on a large sample size of both healthy and pathological subjects, to systematically validate its reliability and impact in clinical setting.

© 2021 Marcelli et al.

Keywords: COVID-19; cardiovascular measurements; central venous pressure; heart failure; home monitoring; non-invasive device; pulmonary artery pressure

Conflict of interest statement

E.M., L.C., B.B. have served as consultants for TRE ESSE Progettazione Biomedica srl. within the consultancy agreement between DIMES Department of Alma Mater Studiorum - Università di Bologna, and TRE

References

  1. Lancet Respir Med. 2021 Jan;9(1):107-116 - PubMed
  2. Sci Rep. 2018 Dec 10;8(1):17757 - PubMed
  3. J Physiol. 1993 May;464:407-22 - PubMed
  4. J Emerg Med. 2010 Jun;38(5):632-7 - PubMed
  5. Anaesth Intensive Care. 2003 Feb;31(1):34-9 - PubMed
  6. Minerva Anestesiol. 2003 May;69(5):330-2 - PubMed
  7. JAMA. 1996 Feb 28;275(8):630-4 - PubMed
  8. JACC Case Rep. 2020 Jul 15;2(9):1379-1382 - PubMed
  9. J Am Soc Echocardiogr. 2015 Jan;28(1):40-56 - PubMed
  10. JAMA. 1989 Feb 10;261(6):884-8 - PubMed
  11. J Am Coll Cardiol. 2009 Feb 17;53(7):582-588 - PubMed
  12. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L277-L288 - PubMed
  13. J Appl Physiol (1985). 1999 Oct;87(4):1555-63 - PubMed
  14. Med Intensiva. 2017 Nov;41(8):483-486 - PubMed
  15. J Cardiothorac Vasc Anesth. 2001 Feb;15(1):40-3 - PubMed
  16. Heart Vessels. 2018 Jul;33(7):733-739 - PubMed
  17. Resuscitation. 2005 Feb;64(2):193-9 - PubMed
  18. N Engl J Med. 2006 Feb 9;354(6):548-51 - PubMed
  19. Heart. 2015 Sep;101(18):1499-504 - PubMed
  20. Eur Radiol. 2021 Jun;31(6):4031-4041 - PubMed
  21. J Vasc Surg. 1987 Jan;5(1):148-59 - PubMed
  22. J Heart Lung Transplant. 1999 Nov;18(11):1126-32 - PubMed
  23. Cardiovasc Intervent Radiol. 2003 Jul-Aug;26(4):321-33 - PubMed
  24. Circ Res. 2019 May 24;124(11):1551-1567 - PubMed
  25. Cardiology. 2000;93(1-2):26-30 - PubMed
  26. Hepat Med. 2010 May 25;2:49-67 - PubMed
  27. J Med Assoc Thai. 2012 Mar;95(3):320-4 - PubMed
  28. J Thorac Cardiovasc Surg. 2005 Apr;129(4):912-8 - PubMed
  29. Pulm Circ. 2020 Jul 10;10(3):2045894020933087 - PubMed
  30. J Neurosurg. 1993 Sep;79(3):421-7 - PubMed
  31. Resuscitation. 2009 Oct;80(10):1130-6 - PubMed
  32. Circ Heart Fail. 2012 Jul 1;5(4):414-21 - PubMed
  33. Circulation. 2017 Apr 18;135(16):1509-1517 - PubMed
  34. J Vasc Surg. 1990 Dec;12(6):754-60 - PubMed
  35. J Physiol. 2002 Sep 15;543(Pt 3):1025-31 - PubMed
  36. Lancet Rheumatol. 2020 Jul;2(7):e437-e445 - PubMed
  37. Resuscitation. 2006 Aug;70(2):238-46 - PubMed
  38. Clin Kidney J. 2016 Feb;9(1):39-47 - PubMed
  39. J Hepatol. 2010 Feb;52(2):206-10 - PubMed
  40. Am J Cardiol. 1990 Dec 1;66(19):1348-54 - PubMed
  41. Card Fail Rev. 2019 Feb;5(1):9-18 - PubMed
  42. Crit Care Med. 2013 Feb;41(2):580-637 - PubMed
  43. Am J Emerg Med. 2012 Oct;30(8):1414-1419.e1 - PubMed
  44. Curr Heart Fail Rep. 2009 Dec;6(4):287-92 - PubMed
  45. Clin J Am Soc Nephrol. 2006 Jul;1(4):749-53 - PubMed
  46. PLoS One. 2014 Oct 03;9(10):e109215 - PubMed
  47. Circulation. 2020 Mar 3;141(9):e139-e596 - PubMed
  48. Eur Heart J. 2015 Jun 14;36(23):1437-44 - PubMed
  49. J Am Soc Echocardiogr. 2010 Jul;23(7):685-713; quiz 786-8 - PubMed
  50. World J Gastroenterol. 2016 Dec 28;22(48):10482-10501 - PubMed
  51. Rev Port Cardiol. 2002 Feb;21(2):125-33 - PubMed
  52. Crit Care Med. 2002 Feb;30(2):454-60 - PubMed
  53. Circulation. 2008 Sep 30;118(14):1433-41 - PubMed
  54. J Am Coll Cardiol. 2009 Feb 17;53(7):589-596 - PubMed
  55. Heart. 2007 Sep;93(9):1137-46 - PubMed
  56. J Vasc Surg Venous Lymphat Disord. 2019 May;7(3):428-440 - PubMed
  57. JACC Cardiovasc Imaging. 2017 Oct;10(10 Pt B):1285-1286 - PubMed
  58. Pulm Circ. 2020 Jul 2;10(3):2045894020936660 - PubMed
  59. Ann Intensive Care. 2018 Sep 20;8(1):91 - PubMed
  60. J Cardiothorac Vasc Anesth. 2004 Aug;18(4):446-50 - PubMed
  61. Shock. 2010 Mar;33(3):269-73 - PubMed
  62. ESC Heart Fail. 2021 Feb;8(1):714-718 - PubMed
  63. J Am Coll Cardiol. 2003 May 21;41(10):1797-804 - PubMed
  64. Acta Radiol. 2017 May;58(5):537-541 - PubMed
  65. Curr Opin Crit Care. 2006 Jun;12(3):219-27 - PubMed
  66. J Physiol. 1997 Sep 1;503 ( Pt 2):463-7 - PubMed
  67. Curr Opin Clin Nutr Metab Care. 2001 May;4(3):207-10 - PubMed
  68. J Clin Ultrasound. 2011 Jul;39(6):337-43 - PubMed
  69. J Card Fail. 2019 Aug;25(8):643-644 - PubMed
  70. Am Heart J. 1998 Jul;136(1):10-8 - PubMed
  71. Hepatology. 2018 Oct;68(4):1633-1641 - PubMed
  72. Ann Card Anaesth. 2016 Jul-Sep;19(3):405-9 - PubMed
  73. Circulation. 2020 Feb 25;141(8):678-693 - PubMed
  74. Am J Emerg Med. 2000 Jul;18(4):432-4 - PubMed
  75. J Vasc Surg. 1994 Nov;20(5):721-7 - PubMed
  76. Cardiovasc Diagn Ther. 2020 Oct;10(5):1604-1624 - PubMed
  77. J Am Coll Cardiol. 2007 Oct 16;50(16):1584-9 - PubMed

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