Display options
Cite
Müller J, Bertsch T, Volke J, et al. Narrative review of metabolomics in cardiovascular disease. J Thorac Dis. 2021;13(4):2532-2550doi: 10.21037/jtd-21-22.
Müller, J., Bertsch, T., Volke, J., Schmid, A., Klingbeil, R., Metodiev, Y., Karaca, B., Kim, S. H., Lindner, S., Schupp, T., Kittel, M., Poschet, G., Akin, I., & Behnes, M. (2021). Narrative review of metabolomics in cardiovascular disease. Journal of thoracic disease, 13(4), 2532-2550. https://doi.org/10.21037/jtd-21-22
Müller, Julian, et al. "Narrative review of metabolomics in cardiovascular disease." Journal of thoracic disease vol. 13,4 (2021): 2532-2550. doi: https://doi.org/10.21037/jtd-21-22
Müller J, Bertsch T, Volke J, Schmid A, Klingbeil R, Metodiev Y, Karaca B, Kim SH, Lindner S, Schupp T, Kittel M, Poschet G, Akin I, Behnes M. Narrative review of metabolomics in cardiovascular disease. J Thorac Dis. 2021 Apr;13(4):2532-2550. doi: 10.21037/jtd-21-22. PMID: 34012599; PMCID: PMC8107570.
Copy Download .nbib Format: NLM
Share it on

J Thorac Dis. 2021 Apr;13(4):2532-2550. doi: 10.21037/jtd-21-22.

Narrative review of metabolomics in cardiovascular disease.

Journal of thoracic disease

Julian Müller, Thomas Bertsch, Justus Volke, Alexander Schmid, Rebecca Klingbeil, Yulian Metodiev, Bican Karaca, Seung-Hyun Kim, Simon Lindner, Tobias Schupp, Maximilian Kittel, Gernot Poschet, Ibrahim Akin, Michael Behnes

Affiliations

  1. First Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
  2. Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Nuremburg General Hospital, Paracelsus Medical University, Nuremberg, Germany.
  3. Institute for Clinical Chemistry, Faculty of Medicine Mannheim, Heidelberg University, Mannheim, Germany.
  4. Centre for Organismal Studies (COS), University of Heidelberg, Heidelberg, Germany.

PMID: 34012599 PMCID: PMC8107570 DOI: 10.21037/jtd-21-22

Abstract

Cardiovascular diseases are accompanied by disorders in the cardiac metabolism. Furthermore, comorbidities often associated with cardiovascular disease can alter systemic and myocardial metabolism contributing to worsening of cardiac performance and health status. Biomarkers such as natriuretic peptides or troponins already support diagnosis, prognosis and treatment of patients with cardiovascular diseases and are represented in international guidelines. However, as cardiovascular diseases affect various pathophysiological pathways, a single biomarker approach cannot be regarded as ideal to reveal optimal clinical application. Emerging metabolomics technology allows the measurement of hundreds of metabolites in biological fluids or biopsies and thus to characterize each patient by its own metabolic fingerprint, improving our understanding of complex diseases, significantly altering the management of cardiovascular diseases and possibly personalizing medicine. This review outlines current knowledge, perspectives as well as limitations of metabolomics for diagnosis, prognosis and treatment of cardiovascular diseases such as heart failure, atherosclerosis, ischemic and non-ischemic cardiomyopathy. Furthermore, an ongoing research project tackling current inconsistencies as well as clinical applications of metabolomics will be discussed. Taken together, the application of metabolomics will enable us to gain more insights into pathophysiological interactions of metabolites and disease states as well as improving therapies of patients with cardiovascular diseases in the future.

2021 Journal of Thoracic Disease. All rights reserved.

Keywords: Metabolomics; atherosclerosis; heart failure; ischemic heart disease

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/jtd-21-22). The authors have no conflicts of interest to declare.

References

  1. Nat Rev Endocrinol. 2014 Dec;10(12):723-36 - PubMed
  2. Scand J Clin Lab Invest. 2010 Apr 19;70(3):217-24 - PubMed
  3. Expert Rev Cardiovasc Ther. 2014 Aug;12(8):919-22 - PubMed
  4. J Am Coll Cardiol. 2012 May 1;59(18):1629-41 - PubMed
  5. J Am Coll Cardiol. 2015 Apr 21;65(15):1509-20 - PubMed
  6. J Am Coll Cardiol. 2008 Jul 8;52(2):117-23 - PubMed
  7. Circulation. 2009 Apr 7;119(13):1736-46 - PubMed
  8. Int Heart J. 2017 May 31;58(3):441-446 - PubMed
  9. J Am Coll Cardiol. 2008 Feb 5;51(5):585-94 - PubMed
  10. Circulation. 2016 Feb 23;133(8):706-16 - PubMed
  11. Heart. 2017 Aug;103(16):1278-1285 - PubMed
  12. Anal Biochem. 2001 Jun 1;293(1):16-21 - PubMed
  13. Methods Mol Biol. 2019;2037:189-194 - PubMed
  14. J Hepatol. 2015 Apr;62(4):841-7 - PubMed
  15. Obesity (Silver Spring). 2010 Sep;18(9):1695-700 - PubMed
  16. Annu Rev Physiol. 1981;43:419-30 - PubMed
  17. Eur Heart J. 2018 Jan 7;39(2):119-177 - PubMed
  18. Sci Rep. 2020 Oct 20;10(1):17838 - PubMed
  19. Anal Bioanal Chem. 2019 Sep;411(23):6189-6202 - PubMed
  20. Cardiovasc Res. 1997 Feb;33(2):243-57 - PubMed
  21. Nature. 2014 Nov 20;515(7527):431-435 - PubMed
  22. Circ Heart Fail. 2014 Nov;7(6):1022-31 - PubMed
  23. Nature. 2008 Oct 23;455(7216):1054-6 - PubMed
  24. Circulation. 1996 Oct 15;94(8):1894-901 - PubMed
  25. Cardiovasc Res. 2008 Jul 15;79(2):249-58 - PubMed
  26. Nat Rev Immunol. 2015 Aug;15(8):511-23 - PubMed
  27. Anal Chem. 2009 Dec 15;81(24):10038-48 - PubMed
  28. N Engl J Med. 1992 Sep 3;327(10):669-77 - PubMed
  29. Eur Heart J. 1990 Apr;11 Suppl B:108-15 - PubMed
  30. J Clin Invest. 1987 Feb;79(2):359-66 - PubMed
  31. Circ Res. 2009 Mar 27;104(6):805-12 - PubMed
  32. Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1160-H1169 - PubMed
  33. Am Heart J. 2012 May;163(5):844-850.e1 - PubMed
  34. Circulation. 2016 May 24;133(21):2038-49 - PubMed
  35. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 15;879(17-18):1467-75 - PubMed
  36. J Mol Cell Cardiol. 2013 Feb;55:42-9 - PubMed
  37. N Engl J Med. 2007 Mar 15;356(11):1140-51 - PubMed
  38. Hypertension. 2010 Feb;55(2):508-15 - PubMed
  39. Lancet. 1963 Apr 13;1(7285):785-9 - PubMed
  40. J Pharm Biomed Anal. 2015 Sep 10;113:108-20 - PubMed
  41. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jun 1;1117:136-147 - PubMed
  42. Curr Metabolomics. 2016 Aug;4(2):116-120 - PubMed
  43. Mol Syst Biol. 2009;5:259 - PubMed
  44. J Mol Cell Cardiol. 2013 Feb;55:12-8 - PubMed
  45. J Mol Cell Cardiol. 2005 Feb;38(2):309-13 - PubMed
  46. N Engl J Med. 1987 Jun 4;316(23):1429-35 - PubMed
  47. Circulation. 2005 Dec 20;112(25):3868-75 - PubMed
  48. Circ Cardiovasc Genet. 2010 Apr;3(2):207-14 - PubMed
  49. J Clin Exp Hepatol. 2019 Sep-Oct;9(5):597-606 - PubMed
  50. J Am Heart Assoc. 2015 Feb 24;4(2): - PubMed
  51. Nat Rev Cardiol. 2013 Sep;10(9):531-47 - PubMed
  52. J Clin Invest. 1991 Feb;87(2):554-60 - PubMed
  53. Amino Acids. 2014 Sep;46(9):2205-17 - PubMed
  54. Prog Lipid Res. 2003 Jul;42(4):344-57 - PubMed
  55. Basic Res Cardiol. 2012 Nov;107(6):294 - PubMed
  56. N Engl J Med. 1996 May 23;334(21):1349-55 - PubMed
  57. Cardiovasc Res. 2009 Feb 15;81(3):420-8 - PubMed
  58. Hypertension. 2004 Nov;44(5):662-7 - PubMed
  59. Lancet. 2003 Sep 6;362(9386):759-66 - PubMed
  60. J Clin Invest. 2008 Oct;118(10):3503-12 - PubMed
  61. Diabetes Care. 2016 Jul;39(7):1115-22 - PubMed
  62. J Transl Med. 2015 Sep 12;13:297 - PubMed
  63. Eur Heart J. 2016 Jan 14;37(3):267-315 - PubMed
  64. Sci Rep. 2016 Nov 08;6:36359 - PubMed
  65. Circulation. 1996 Dec 1;94(11):2837-42 - PubMed
  66. Circulation. 2001 Dec 11;104(24):2923-31 - PubMed
  67. J Mol Cell Cardiol. 2013 May;58:225-31 - PubMed
  68. Curr Protoc Mol Biol. 2016 Apr 01;114:30.4.1-30.4.32 - PubMed
  69. Nat Med. 2002 Dec;8(12):1439-44 - PubMed
  70. Cell. 2015 Dec 17;163(7):1585-95 - PubMed
  71. Nutr Metab Cardiovasc Dis. 2015 Oct;25(10):937-42 - PubMed
  72. BMC Bioinformatics. 2011 Oct 14;12:400 - PubMed
  73. Circ Res. 2013 Aug 30;113(6):709-24 - PubMed
  74. J Mol Cell Cardiol. 2009 Jun;46(6):781-8 - PubMed
  75. Nat Biotechnol. 2001 Jan;19(1):45-50 - PubMed
  76. Circulation. 1994 Oct;90(4):1765-73 - PubMed
  77. Basic Res Cardiol. 2006 Jan;101(1):17-26 - PubMed
  78. PLoS One. 2014 Jun 09;9(6):e99598 - PubMed
  79. Methods Mol Biol. 2019;2037:35-47 - PubMed
  80. PLoS One. 2015 Aug 10;10(8):e0135228 - PubMed
  81. J Mol Cell Cardiol. 1994 Oct;26(10):1371-5 - PubMed
  82. Sci Rep. 2018 Aug 28;8(1):12958 - PubMed
  83. J Am Coll Cardiol. 1996 Sep;28(3):665-72 - PubMed
  84. Diabetes. 2009 Nov;58(11):2429-43 - PubMed
  85. Am J Cardiol. 1998 Jan 1;81(1):45-50 - PubMed
  86. Cardiovasc Res. 2010 Jun 1;86(3):461-70 - PubMed
  87. J Mol Cell Cardiol. 2011 Jun;50(6):964-71 - PubMed
  88. Nat Rev Cardiol. 2011 Oct 25;9(2):91-100 - PubMed
  89. Circ Res. 2018 Apr 27;122(9):1238-1258 - PubMed
  90. N Engl J Med. 2001 Dec 6;345(23):1667-75 - PubMed
  91. Exp Biol Med (Maywood). 2012 Dec;237(12):1369-78 - PubMed
  92. Cell Metab. 2013 Jul 2;18(1):43-50 - PubMed
  93. Eur J Heart Fail. 2016 Aug;18(8):891-975 - PubMed
  94. Mol Cell Biochem. 2018 Jan;438(1-2):167-174 - PubMed
  95. Circ Res. 1999 Oct 29;85(9):770-6 - PubMed
  96. Atherosclerosis. 2014 Feb;232(2):260-4 - PubMed
  97. Circulation. 1992 Dec;86(6):1810-8 - PubMed
  98. Cell Metab. 2008 Jan;7(1):45-56 - PubMed
  99. Nat Rev Mol Cell Biol. 2008 Feb;9(2):162-76 - PubMed
  100. Am J Physiol. 1992 Apr;262(4 Pt 2):H1068-74 - PubMed
  101. Prog Nucl Magn Reson Spectrosc. 2014 Nov;83:42-9 - PubMed
  102. Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H351-62 - PubMed
  103. Physiol Rev. 2005 Jul;85(3):1093-129 - PubMed
  104. J Chromatogr A. 2017 Jul 28;1508:163-168 - PubMed
  105. Circulation. 2020 Mar 17;141(11):916-930 - PubMed
  106. Circulation. 2018 Mar 27;137(13):1374-1390 - PubMed
  107. Am J Physiol. 1994 Aug;267(2 Pt 2):H742-50 - PubMed
  108. Circulation. 2005 Nov 15;112(20):3131-9 - PubMed
  109. Ann N Y Acad Sci. 2004 May;1015:202-13 - PubMed
  110. PLoS Genet. 2014 Dec 11;10(12):e1004801 - PubMed
  111. Circ Res. 2016 May 13;118(10):1659-701 - PubMed
  112. J Mass Spectrom. 2005 Apr;40(4):430-43 - PubMed
  113. J Mol Cell Cardiol. 2013 Jun;59:76-85 - PubMed
  114. Rapid Commun Mass Spectrom. 2018 Sep 15;32(17):1497-1506 - PubMed
  115. Circ Res. 2008 Aug 1;103(3):279-88 - PubMed
  116. Physiol Rev. 2010 Jan;90(1):207-58 - PubMed
  117. Circulation. 2004 Aug 24;110(8):894-6 - PubMed
  118. Front Physiol. 2018 Aug 29;9:1017 - PubMed
  119. Lancet. 2015 Jan 10;385(9963):117-71 - PubMed
  120. Cardiovasc Res. 2019 Sep 1;115(11):1606-1616 - PubMed
  121. J Nutr. 2005 Sep;135(9):2271-3 - PubMed
  122. Anal Chem. 2017 Jul 5;89(13):6963-6968 - PubMed
  123. Anal Chem. 2011 Jun 15;83(12):4871-80 - PubMed
  124. Circulation. 2001 Jun 5;103(22):2681-6 - PubMed
  125. J Am Coll Cardiol. 2016 Jan 26;67(3):291-9 - PubMed
  126. Int Heart J. 2016;57(1):11-7 - PubMed
  127. Curr Biol. 1994 Jan 1;4(1):42-6 - PubMed
  128. J Am Heart Assoc. 2018 Apr 6;7(8): - PubMed
  129. Circulation. 2010 Nov 30;122(22):2273-80 - PubMed
  130. J Card Fail. 2015 Jun;21(6):460-9 - PubMed
  131. J Am Coll Cardiol. 2016 Dec 27;68(25):2850-2870 - PubMed
  132. J Mol Cell Cardiol. 2009 Jul;47(1):142-8 - PubMed
  133. PLoS One. 2013;8(4):e60292 - PubMed
  134. Cardiovasc Res. 2013 Jan 1;97(1):66-76 - PubMed
  135. Atherosclerosis. 2014 Jan;232(1):191-6 - PubMed
  136. J Am Coll Cardiol. 2016 Sep 20;68(12):1281-93 - PubMed
  137. Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1055-63 - PubMed
  138. Anal Chem. 2015 Mar 3;87(5):2925-30 - PubMed
  139. Eur J Clin Invest. 2011 May;41(5):527-38 - PubMed
  140. Nat Med. 2006 Jun;12(6):705-10 - PubMed
  141. Bioanalysis. 2019 Jan 21;: - PubMed
  142. Metab Eng. 2007 Jan;9(1):39-51 - PubMed
  143. Circulation. 2005 Oct 11;112(15):2339-46 - PubMed
  144. Magn Reson Chem. 2005 Sep;43(9):681-7 - PubMed
  145. Circulation. 2012 Aug 28;126(9):1110-20 - PubMed
  146. Medicine (Baltimore). 1951 Feb;30(1):21-41 - PubMed
  147. Microbiome. 2018 Apr 20;6(1):73 - PubMed
  148. Cell. 2016 Mar 24;165(1):111-124 - PubMed
  149. Circ Cardiovasc Genet. 2014 Jun;7(3):266-76 - PubMed
  150. Analyst. 2019 Jul 21;144(14):4331-4341 - PubMed
  151. Circ Heart Fail. 2009 Sep;2(5):417-23 - PubMed
  152. Circulation. 2007 Apr 17;115(15):2033-41 - PubMed
  153. Eur Heart J. 1995 Dec;16 Suppl O:115-8 - PubMed
  154. Arch Biochem Biophys. 1976 Mar;173(1):34-41 - PubMed
  155. J Clin Invest. 2014 Oct;124(10):4204-11 - PubMed
  156. Metabolomics. 2013 Jun;9(3):558-563 - PubMed
  157. PLoS One. 2015 May 26;10(5):e0124844 - PubMed
  158. Nat Rev Mol Cell Biol. 2008 Mar;9(3):193-205 - PubMed
  159. Circ Cardiovasc Genet. 2015 Apr;8(2):410-9 - PubMed
  160. J Clin Bioinforma. 2015 Mar 13;5:3 - PubMed
  161. Am J Physiol. 1973 Sep;225(3):651-8 - PubMed
  162. Circ Res. 2001 Jun 8;88(11):1159-67 - PubMed
  163. Circ Heart Fail. 2014 Jul;7(4):634-42 - PubMed
  164. J Nucl Cardiol. 2009 May-Jun;16(3):411-21 - PubMed
  165. Mol Cell Biochem. 1998 Mar;180(1-2):117-28 - PubMed
  166. J Mol Cell Cardiol. 2008 Feb;44(2):315-22 - PubMed
  167. J Am Coll Cardiol. 2002 Jul 17;40(2):271-7 - PubMed
  168. Circulation. 2016 Feb 23;133(8):698-705 - PubMed
  169. Circulation. 1991 May;83(5 Suppl):III8-13 - PubMed
  170. J Pharm Biomed Anal. 2014 Jan;88:225-34 - PubMed
  171. Eur J Epidemiol. 2018 Jan;33(1):55-66 - PubMed
  172. J Chronic Dis. 1959 May;9(5):442-64 - PubMed
  173. J Clin Invest. 1976 Nov;58(5):1185-92 - PubMed
  174. Circulation. 2002 Jul 30;106(5):606-12 - PubMed
  175. Mol Biosyst. 2013 Nov;9(11):2618-26 - PubMed
  176. Circulation. 1999 May 4;99(17):2261-7 - PubMed
  177. PLoS One. 2013;8(4):e60737 - PubMed
  178. Anal Chem. 2016 Oct 4;88(19):9821-9829 - PubMed
  179. PLoS One. 2014 Feb 05;9(2):e88102 - PubMed
  180. Physiol Res. 2020 Nov 16;69(5):823-834 - PubMed
  181. Methods Mol Biol. 2019;1978:287-299 - PubMed
  182. JACC Basic Transl Sci. 2016 Oct;1(6):432-444 - PubMed
  183. Cardiovasc Res. 2001 Dec;52(3):407-16 - PubMed
  184. Circulation. 1999 Feb 9;99(5):641-8 - PubMed
  185. J Biol Chem. 1993 Oct 15;268(29):22119-26 - PubMed
  186. PLoS One. 2017 Apr 17;12(4):e0175591 - PubMed
  187. J Am Heart Assoc. 2016 Jul 29;5(8): - PubMed
  188. Am J Physiol. 1980 Dec;239(6):E430-6 - PubMed
  189. Circulation. 2006 Sep 12;114(11):1151-8 - PubMed

Publication Types