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Cordero A, Martínez Rey-Rañal E, Moreno MJ, et al. Predictive Value of Pro-BNP for Heart Failure Readmission after an Acute Coronary Syndrome. J Clin Med. 2021;10(8)doi: 10.3390/jcm10081653.
Cordero, A., Martínez Rey-Rañal, E., Moreno, M. J., Escribano, D., Moreno-Arribas, J., Quintanilla, M. A., Zuazola, P., Núñez, J., & Bertomeu-González, V. (2021). Predictive Value of Pro-BNP for Heart Failure Readmission after an Acute Coronary Syndrome. Journal of clinical medicine, 10(8), . https://doi.org/10.3390/jcm10081653
Cordero, Alberto, et al. "Predictive Value of Pro-BNP for Heart Failure Readmission after an Acute Coronary Syndrome." Journal of clinical medicine vol. 10,8 (2021). doi: https://doi.org/10.3390/jcm10081653
Cordero A, Martínez Rey-Rañal E, Moreno MJ, Escribano D, Moreno-Arribas J, Quintanilla MA, Zuazola P, Núñez J, Bertomeu-González V. Predictive Value of Pro-BNP for Heart Failure Readmission after an Acute Coronary Syndrome. J Clin Med. 2021 Apr 13;10(8). doi: 10.3390/jcm10081653. PMID: 33924437; PMCID: PMC8069470.
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J Clin Med. 2021 Apr 13;10(8). doi: 10.3390/jcm10081653.

Predictive Value of Pro-BNP for Heart Failure Readmission after an Acute Coronary Syndrome.

Journal of clinical medicine

Alberto Cordero, Elías Martínez Rey-Rañal, María J Moreno, David Escribano, José Moreno-Arribas, Maria A Quintanilla, Pilar Zuazola, Julio Núñez, Vicente Bertomeu-González

Affiliations

  1. Cardiology Department, Hospital Universitario de San Juan, 03550 Alicante, Spain.
  2. Unidad de Investigación en Cardiología, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), 46020 Valencia, Spain.
  3. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV CB16/11/00226-CB16/11/00420), 28028 Madrid, Spain.
  4. Cardiology Department, Hospital Clínico Universitario, 46010 Valencia, Spain.
  5. Instituto de Investigación Sanitaria (INCLIVA), Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain.

PMID: 33924437 PMCID: PMC8069470 DOI: 10.3390/jcm10081653

Abstract

BACKGROUND: N-terminal pro-brain natural peptide (NT-pro-BNP) is a well-established biomarker of tissue congestion and has prognostic value in patients with heart failure (HF). Nonetheless, there is scarce evidence on its predictive capacity for HF re-admission after an acute coronary syndrome (ACS). We performed a prospective, single-center study in all patients discharged after an ACS. HF re-admission was analyzed by competing risk regression, taking all-cause mortality as a competing event. Results are presented as sub-hazard ratios (sHR). Recurrent hospitalizations were tested by negative binomial regression, and results are presented as incidence risk ratio (IRR).

RESULTS: Of the 2133 included patients, 528 (24.8%) had HF during the ACS hospitalization, and their pro-BNP levels were higher (3220 pg/mL vs. 684.2 pg/mL;

CONCLUSIONS: In-hospital determination of pro-BNP is an independent predictor of HF readmission after an ACS.

Keywords: acute coronary syndrome; heart failure; pro-BNP

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