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Jozefowicz-Korczynska M, Pajor A, Lucas Grzelczyk W. The Ototoxicity of Antimalarial Drugs-A State of the Art Review. Front Neurol. 2021;12:661740doi: 10.3389/fneur.2021.661740.
Jozefowicz-Korczynska, M., Pajor, A., & Lucas Grzelczyk, W. (2021). The Ototoxicity of Antimalarial Drugs-A State of the Art Review. Frontiers in neurology, 12661740. https://doi.org/10.3389/fneur.2021.661740
Jozefowicz-Korczynska, Magdalena, et al. "The Ototoxicity of Antimalarial Drugs-A State of the Art Review." Frontiers in neurology vol. 12 (2021): 661740. doi: https://doi.org/10.3389/fneur.2021.661740
Jozefowicz-Korczynska M, Pajor A, Lucas Grzelczyk W. The Ototoxicity of Antimalarial Drugs-A State of the Art Review. Front Neurol. 2021 Apr 20;12:661740. doi: 10.3389/fneur.2021.661740. eCollection 2021. PMID: 33959089; PMCID: PMC8093564.
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Front Neurol. 2021 Apr 20;12:661740. doi: 10.3389/fneur.2021.661740. eCollection 2021.

The Ototoxicity of Antimalarial Drugs-A State of the Art Review.

Frontiers in neurology

Magdalena Jozefowicz-Korczynska, Anna Pajor, Weronika Lucas Grzelczyk

Affiliations

  1. Balance Disorders Unit, Otolaryngology Department, The Norbert Barlicki Memorial Teaching Hospital, Medical University of Lodz, Lodz, Poland.
  2. Department of Otolaryngology, Head and Neck Oncology, The Norbert Barlicki Memorial Teaching Hospital, Medical University of Lodz, Lodz, Poland.

PMID: 33959089 PMCID: PMC8093564 DOI: 10.3389/fneur.2021.661740

Abstract

This review summarizes current knowledge about the occurrence of hearing and balance disorders after antimalarial drugs treatment. It also examines the clinical applications of antimalarials, their mechanisms behind this ototoxicity and how it can be monitored. It includes studies with larger numbers of patients and those in which auditory function was assessed using audiological tests. Some antimalarials have been repurposed for other conditions like autoimmune disorders, rheumatic diseases, some viral diseases and cancers. While old antimalarial drugs, such as quinoline derivatives, are known to demonstrate ototoxicity, a number of new synthetic antimalarial agents particularly artemisinin derivatives, demonstrate unknown ototoxicity. Adverse audiovestibular effects vary depending on the medication itself, its dose and route of administration, as well as the drug combination, treated disease and individual predispositions of the patient. Dizziness was commonly reported, while vestibular symptoms, hearing loss and tinnitus were observed much less frequently, and most of these symptoms were reversible. As early identification of ototoxic hearing loss is critical to introducing possible alternative treatments with less ototoxic medications, therefore monitoring systems of those drugs ototoxic side effects are much needed.

Copyright © 2021 Jozefowicz-Korczynska, Pajor and Lucas Grzelczyk.

Keywords: antimalarials; dizziness; hearing loss; ototoxicity; tinnitus; vertigo

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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