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Patlolla VGR, Popovic N, Peter Holbrook W, et al. Effect of Doxycycline Microencapsulation on Buccal Films: Stability, Mucoadhesion and In Vitro Drug Release. Gels. 2021;7(2)doi: 10.3390/gels7020051.
Patlolla, V. G. R., Popovic, N., Peter Holbrook, W., Kristmundsdottir, T., & Gizurarson, S. (2021). Effect of Doxycycline Microencapsulation on Buccal Films: Stability, Mucoadhesion and In Vitro Drug Release. Gels (Basel, Switzerland), 7(2), . https://doi.org/10.3390/gels7020051
Patlolla, Venu Gopal Reddy, et al. "Effect of Doxycycline Microencapsulation on Buccal Films: Stability, Mucoadhesion and In Vitro Drug Release." Gels (Basel, Switzerland) vol. 7,2 (2021). doi: https://doi.org/10.3390/gels7020051
Patlolla VGR, Popovic N, Peter Holbrook W, Kristmundsdottir T, Gizurarson S. Effect of Doxycycline Microencapsulation on Buccal Films: Stability, Mucoadhesion and In Vitro Drug Release. Gels. 2021 Apr 28;7(2). doi: 10.3390/gels7020051. PMID: 33924744; PMCID: PMC8167737.
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Gels. 2021 Apr 28;7(2). doi: 10.3390/gels7020051.

Effect of Doxycycline Microencapsulation on Buccal Films: Stability, Mucoadhesion and In Vitro Drug Release.

Gels (Basel, Switzerland)

Venu Gopal Reddy Patlolla, Nikolina Popovic, William Peter Holbrook, Thordis Kristmundsdottir, Sveinbjörn Gizurarson

Affiliations

  1. Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, 107 Reykjavik, Iceland.
  2. Faculty of Odontology, University of Iceland, Vatnsmýrarveg 16, 101 Reykjavík, Iceland.
  3. Costco Pharmacy, Kauptúni 3, 210 Garðabær, Iceland.
  4. Pharmacy Department, College of Medicine, University of Malawi, Blantyre 3, Malawi.

PMID: 33924744 PMCID: PMC8167737 DOI: 10.3390/gels7020051

Abstract

The aim of this work was to stabilize doxycycline in mucoadhesive buccal films at room temperature (25 °C). Since doxycycline is susceptible to degradation such as oxidation and epimerization, tablets are currently the only formulation that can keep the drug fully stable at room temperature, while liquid formulations are limited to refrigerated conditions (4 °C). In this study, the aim was to make formulations containing subclinical (antibiotic) doxycycline concentration that can act as matrix metalloproteinase inhibitors (MMPI) and can be stored at temperatures such as 25 °C. Here, doxycycline was complexed with excipients using three techniques and entrapped into microparticles that were stored at 4 °C, 25 °C and 40 °C. Effect of addition of precomplexed doxycycline microparticles on films: stability mucoadhesion capacity, tensile strength, swelling index and in vitro release was studied. The complexation efficiency between drug-excipients, microparticles and films was studied using Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Two of the films were found to be stable at 4 °C but the film containing microparticle composed of precomplexed doxycycline with β-cyclodextrin, MgCl

Keywords: MMPI; doxycycline; film; matrix metalloproteinase inhibitor; microparticles

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