Adv Biomed Res. 2021 Feb 26;10:7. doi: 10.4103/abr.abr_173_20. eCollection 2021.
The Prevalence of Hepatitis B Virus Markers among Students of Shiraz University of Medical Sciences.
Advanced biomedical research
Razieh Dowran, Mahyar Malekzadeh, Tayyar Nourollahi, Bahador Sarkari, Jamal Sarvari
Affiliations
Affiliations
- Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
- Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
- Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
- Department of Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
- Department of Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
PMID: 33959564
PMCID: PMC8095257 DOI: 10.4103/abr.abr_173_20
Abstract
BACKGROUND: Protection against hepatitis B virus (HBV) is based on the presence of antibodies against hepatitis B surface antigen (HBsAg). Vaccination of newborns is the most effective means of prevention. This study aimed to evaluate the frequency of anti-HBs antibody (anti-HBsAb), anti-HB core Ab (anti-HBcAb), HBsAg, and HBV DNA among university students in Fars province, Southern Iran.
MATERIALS AND METHODS: In this cross-sectional study, 272 students of Shiraz University of Medical Sciences, were enrolled. Venous blood (5 mL) was collected from each participant and centrifuged; the sera were stored at -20°C until use. Anti-HBsAb, Anti-HBcAb, and HBsAg were measured using a commercial enzyme-linked immunosorbent assay kit. HBV DNA load was also measured by a real-time polymerase chain reaction.
RESULTS: The mean age of the participants was 19 ± 1 years. There were 171 (62.9%) females and 101 (37.1%) males. Anti-HBsAb at a protective level (>10 mIU/mL) were detected in the sera of 104 (38.5%) of the cases. Of the anti-HBsAb seropositive participants, 82 were female and 22 were male; the difference between the gender and seropositivity to anti-HBsAb was statistically significant (
CONCLUSION: Findings of the current study show that more than half of the students do not have a protective level of anti-HBsAb and might be susceptible to HBV infection, indicating the necessity of checking the level of anti-HBsAb as well as a booster dose in high-risk groups.
Copyright: © 2021 Advanced Biomedical Research.
Keywords: Enzyme-Linked Immunosorbent Assay; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B Virus; Student; Vaccination
Conflict of interest statement
There are no conflicts of interest.
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