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Rezaei Z, Mobasheri L, Sadri F. Molecular Insights into COVID-19 Pathophysiology, Immune Pathogenesis, Detection, and Treatment. DNA Cell Biol. 2021;40(7):858-868doi: 10.1089/dna.2021.0068.
Rezaei, Z., Mobasheri, L., & Sadri, F. (2021). Molecular Insights into COVID-19 Pathophysiology, Immune Pathogenesis, Detection, and Treatment. DNA and cell biology, 40(7), 858-868. https://doi.org/10.1089/dna.2021.0068
Rezaei, Zohreh, et al. "Molecular Insights into COVID-19 Pathophysiology, Immune Pathogenesis, Detection, and Treatment." DNA and cell biology vol. 40,7 (2021): 858-868. doi: https://doi.org/10.1089/dna.2021.0068
Rezaei Z, Mobasheri L, Sadri F. Molecular Insights into COVID-19 Pathophysiology, Immune Pathogenesis, Detection, and Treatment. DNA Cell Biol. 2021 Jul;40(7):858-868. doi: 10.1089/dna.2021.0068. Epub 2021 May 14. PMID: 33989051.
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DNA Cell Biol. 2021 Jul;40(7):858-868. doi: 10.1089/dna.2021.0068. Epub 2021 May 14.

Molecular Insights into COVID-19 Pathophysiology, Immune Pathogenesis, Detection, and Treatment.

DNA and cell biology

Zohreh Rezaei, Leila Mobasheri, Farzad Sadri

Affiliations

  1. Department of Biology, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran.
  2. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
  3. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
  4. Department of Medical Immunology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
  5. Young Researchers and Elite Club, Yasooj Branch, Islamic Azad University, Yasooj, Iran.

PMID: 33989051 DOI: 10.1089/dna.2021.0068

Abstract

In late December 2019, a new kind of Coronavirus called severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) was officially identified in Wuhan, China. In March 2020, SARS-CoV-2 was declared a pandemic by the World Health Organization (WHO), and it has infected millions of people worldwide. SARS-CoV-2 is a highly contagious Coronavirus, which has led to an outbreak of acute respiratory tract infection called "Coronavirus disease 2019" (COVID-19), resulting in mild to severe respiratory infections in humans. The design of appropriate therapeutic approaches is dependent on the understanding of molecular and cellular pathways of Coronavirus infections. In this study, we summarized the characteristic features of SARS-CoV-2. In addition, we considered the recent information regarding COVID-19 molecular immune pathogenesis, diagnosis, and potential treatment, which may provide novel perspectives and therapeutic goals in combating SARS-CoV-2.

Keywords: COVID-19; SARS-CoV-2; cytokine storm; diagnosis; treatment

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