Display options
Cite
Skoda R, Bárczi G, Vágó H, et al. Prognosis of the non-ST elevation myocardial infarction complicated with early ventricular fibrillation at higher age. Geroscience. 2021;43(5):2561-2571doi: 10.1007/s11357-021-00377-3.
Skoda, R., Bárczi, G., Vágó, H., Nemes, A., Szabó, L., Fülöp, G., Hizoh, I., Domokos, D., Törő, K., Dinya, E., Merkely, B., & Becker, D. (2021). Prognosis of the non-ST elevation myocardial infarction complicated with early ventricular fibrillation at higher age. GeroScience, 43(5), 2561-2571. https://doi.org/10.1007/s11357-021-00377-3
Skoda, Réka, et al. "Prognosis of the non-ST elevation myocardial infarction complicated with early ventricular fibrillation at higher age." GeroScience vol. 43,5 (2021): 2561-2571. doi: https://doi.org/10.1007/s11357-021-00377-3
Skoda R, Bárczi G, Vágó H, Nemes A, Szabó L, Fülöp G, Hizoh I, Domokos D, Törő K, Dinya E, Merkely B, Becker D. Prognosis of the non-ST elevation myocardial infarction complicated with early ventricular fibrillation at higher age. Geroscience. 2021 Oct;43(5):2561-2571. doi: 10.1007/s11357-021-00377-3. Epub 2021 May 14. PMID: 33990895; PMCID: PMC8599743.
Copy Download .nbib Format: NLM
Share it on

Geroscience. 2021 Oct;43(5):2561-2571. doi: 10.1007/s11357-021-00377-3. Epub 2021 May 14.

Prognosis of the non-ST elevation myocardial infarction complicated with early ventricular fibrillation at higher age.

GeroScience

Réka Skoda, György Bárczi, Hajnalka Vágó, Attila Nemes, Liliána Szabó, Gábor Fülöp, István Hizoh, Dominika Domokos, Klára Törő, Elek Dinya, Béla Merkely, Dávid Becker

Affiliations

  1. Heart and Vascular Center, Semmelweis University, Városmajor u. 68, Budapest, 1122, Hungary.
  2. Department of Medicine, Albert Szent-Györgyi Clinical Center, Medical Faculty, University of Szeged, Szeged, Hungary.
  3. Heart and Vascular Center, Semmelweis University, Városmajor u. 68, Budapest, 1122, Hungary. [email protected].

PMID: 33990895 PMCID: PMC8599743 DOI: 10.1007/s11357-021-00377-3

Abstract

Early ventricular fibrillation (EVF) predicts mortality in ST-segment elevation myocardial infarction (STEMI) patients. Data are lacking about prognosis and management of non-ST-segment elevation myocardial infarction (NSTEMI) EMI with EVF, especially at higher age. In the daily clinical practice, there is no clear prognosis of patients surviving EVF. The present study aimed to investigate the risk factors and factors influencing the prognosis of NSTEMI patients surviving EVF, especially at higher age. Clinical data, including 30-day and 1-year mortality of 6179 NSTEMI patients, were examined; 2.44% (n=151) survived EVF and were further analyzed using chi-square test and uni- and multivariate analyses. Patients were divided into two age groups below and above the age of 70 years. Survival time was compared with Kaplan-Meier analysis. EVF was an independent risk factor for mortality in NSTEMI patients below (HR: 2.4) and above the age of 70 (HR: 2.1). Mortality rates between the two age groups of NSTEMI patients with EVF did not differ significantly: 30-day mortality was 24% vs 40% (p=0.2709) and 1-year mortality was 39% vs 55% (p=0.2085). Additional mortality after 30 days to 1 year was 15% vs 14.6% (p=0.9728). Clinical characteristics of patients with EVF differed significantly from those without in both age groups. EVF after revascularization-within 48 h-had 11.2 OR for 30-day mortality above the age of 70. EVF in NSTEMI was an independent risk factor for mortality in both age groups. Invasive management and revascularization of NSTEMI patients with EVF is highly recommended. Closer follow-up and selection of patients (independent of age) for ICD implantation in the critical first month is essential.

© 2021. The Author(s).

Keywords: Aging; Early ventricular fibrillation; NSTEMI; Prognosis

References

  1. Eur Heart J. 2018 Jan 7;39(2):119-177 - PubMed
  2. Am J Cardiol. 2015 Sep 1;116(5):678-85 - PubMed
  3. Am J Cardiol. 1987 Oct 1;60(10):755-61 - PubMed
  4. Circulation. 2017 Nov 14;136(20):1908-1919 - PubMed
  5. Eur Heart J Acute Cardiovasc Care. 2012 Dec;1(4):302-11 - PubMed
  6. Am J Cardiol. 2017 Nov 15;120(10):1755-1760 - PubMed
  7. Circulation. 2012 Jul 3;126(1):41-9 - PubMed
  8. Eur Heart J. 2004 Oct;25(20):1814-21 - PubMed
  9. Coron Artery Dis. 2017 Nov;28(7):570-576 - PubMed
  10. Adv Ther. 2009 Apr;26(4):455-61 - PubMed
  11. Circulation. 2002 Jul 16;106(3):309-12 - PubMed
  12. Coron Artery Dis. 2010 Dec;21(8):460-5 - PubMed
  13. Circulation. 2010 Aug 3;122(5):455-62 - PubMed
  14. J Am Heart Assoc. 2015 Jan 05;4(1):e001399 - PubMed
  15. Eur Heart J. 2019 Jan 7;40(2):87-165 - PubMed
  16. Am J Cardiol. 1998 Aug 1;82(3):265-71 - PubMed
  17. Br Med J (Clin Res Ed). 1983 Apr 30;286(6375):1405-8 - PubMed
  18. JAMA Cardiol. 2016 Nov 1;1(8):890-899 - PubMed
  19. Am J Cardiol. 2018 Aug 15;122(4):529-536 - PubMed
  20. J Am Coll Cardiol. 2000 Jan;35(1):144-50 - PubMed
  21. Eur Heart J Acute Cardiovasc Care. 2015 Feb;4(1):16-23 - PubMed
  22. Am J Cardiol. 1990 Nov 15;66(17):1208-11 - PubMed
  23. N Engl J Med. 2005 Jun 23;352(25):2581-8 - PubMed
  24. Fundam Clin Pharmacol. 2003 Apr;17(2):133-45 - PubMed

Publication Types

Grant support