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Bao L, Hao D, Wang X, et al. Transcriptome investigation of anti-inflammation and immuno-regulation mechanism of taurochenodeoxycholic acid. BMC Pharmacol Toxicol. 2021;22(1):23doi: 10.1186/s40360-021-00491-0.
Bao, L., Hao, D., Wang, X., He, X., Mao, W., & Li, P. (2021). Transcriptome investigation of anti-inflammation and immuno-regulation mechanism of taurochenodeoxycholic acid. BMC pharmacology & toxicology, 22(1), 23. https://doi.org/10.1186/s40360-021-00491-0
Bao, Lige, et al. "Transcriptome investigation of anti-inflammation and immuno-regulation mechanism of taurochenodeoxycholic acid." BMC pharmacology & toxicology vol. 22,1 (2021): 23. doi: https://doi.org/10.1186/s40360-021-00491-0
Bao L, Hao D, Wang X, He X, Mao W, Li P. Transcriptome investigation of anti-inflammation and immuno-regulation mechanism of taurochenodeoxycholic acid. BMC Pharmacol Toxicol. 2021 Apr 29;22(1):23. doi: 10.1186/s40360-021-00491-0. PMID: 33926569; PMCID: PMC8086280.
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BMC Pharmacol Toxicol. 2021 Apr 29;22(1):23. doi: 10.1186/s40360-021-00491-0.

Transcriptome investigation of anti-inflammation and immuno-regulation mechanism of taurochenodeoxycholic acid.

BMC pharmacology & toxicology

Lige Bao, Dacheng Hao, Xu Wang, Xiuling He, Wei Mao, Peifeng Li

Affiliations

  1. College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
  2. Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, Hohhot, China.
  3. College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China. [email protected].
  4. Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, Hohhot, China. [email protected].

PMID: 33926569 PMCID: PMC8086280 DOI: 10.1186/s40360-021-00491-0

Abstract

BACKGROUND: Taurochenodeoxycholic acid (TCDCA) is one of the major active components in bile acid. It was proven to have inhibitory activities on inflammation and also participate in host immuno-regulation. TCDCA exerts anti-inflammatory and immuno-regulatory effects through the glucocorticoid receptor (GR) mediated genomic signaling pathway and the G protein-coupled bile acid receptor 5 (TGR5) mediated AC-cAMP-PKA signaling pathway. However, it is unclear whether GR or TGR5 plays an important role in the regulatory effects of TCDCA. In order to further investigate this effects mechanism of TCDCA, the research use the transcriptome to identify the major genes and pathway in the anti-inflammatory and immuno-regulatory effects.

METHODS: After the Fibroblast-like synoviocytes (FLS) being treated by different concentrations (10

RESULTS: Five genes associated with anti-inflammatory and immuno-regulatory effects, include Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glutathione peroxidase 3 (GPX3), Serine/arginine-rich splicing factor-9 (SRSF9), Connective tissue growth factor (CTGF) and Cystatin B (CSTB) were identified. TCDCA at the concentrations of 10

CONCLUSIONS: The anti-inflammatory and immuno-regulatory activities of TCDCA are proven to be related to the up-regulation expression of GPX3, SRSF9 and CSTB.

Keywords: Fibroblast‐like synoviocytes; Glucocorticoid receptor; RNA sequencing; Serine/arginine-rich splicing factor-9; Taurochenodeoxycholic acid

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