Display options
Cite
Sheth PA, Pawar AT, Mote CS, et al. Antianemic activity of polyherbal formulation, Raktavardhak Kadha, against phenylhydrazine-induced anemia in rats. J Ayurveda Integr Med. 2021;12(2):340-345doi: 10.1016/j.jaim.2021.02.009.
Sheth, P. A., Pawar, A. T., Mote, C. S., & More, C. (2021). Antianemic activity of polyherbal formulation, Raktavardhak Kadha, against phenylhydrazine-induced anemia in rats. Journal of Ayurveda and integrative medicine, 12(2), 340-345. https://doi.org/10.1016/j.jaim.2021.02.009
Sheth, Payal A, et al. "Antianemic activity of polyherbal formulation, Raktavardhak Kadha, against phenylhydrazine-induced anemia in rats." Journal of Ayurveda and integrative medicine vol. 12,2 (2021): 340-345. doi: https://doi.org/10.1016/j.jaim.2021.02.009
Sheth PA, Pawar AT, Mote CS, More C. Antianemic activity of polyherbal formulation, Raktavardhak Kadha, against phenylhydrazine-induced anemia in rats. J Ayurveda Integr Med. 2021 Apr-Jun;12(2):340-345. doi: 10.1016/j.jaim.2021.02.009. Epub 2021 May 18. PMID: 34016498; PMCID: PMC8185992.
Copy Download .nbib Format: NLM
Share it on

J Ayurveda Integr Med. 2021 Apr-Jun;12(2):340-345. doi: 10.1016/j.jaim.2021.02.009. Epub 2021 May 18.

Antianemic activity of polyherbal formulation, Raktavardhak Kadha, against phenylhydrazine-induced anemia in rats.

Journal of Ayurveda and integrative medicine

Payal A Sheth, Anil T Pawar, Chandrashekhar S Mote, Chandrakant More

Affiliations

  1. School of Pharmacy, Dr. Vishwanath Karad World Peace University, Pune, Maharashtra, India.
  2. School of Pharmacy, Dr. Vishwanath Karad World Peace University, Pune, Maharashtra, India. Electronic address: [email protected].
  3. Krantisinh Nana Patil College of Veterinary Science, Shirwal, Satara, Maharashtra, India.
  4. Shri Swami Samarth Ayurvedic Pharmaceuticals, Nashik, Maharashtra, India.

PMID: 34016498 PMCID: PMC8185992 DOI: 10.1016/j.jaim.2021.02.009

Abstract

BACKGROUND: Over two billion people around the world suffer from anemia. Majority of populations are using dietary supplements and herbal medicines for the management of the anemic conditions. Many polyherbal formulations such as RaktavardhakKadha (RK), are available in the Indian market as a nutritional supplement and herbal-based medicine for anemia.

OBJECTIVES: The present study is aimed at investigating antianemic potential of polyherbal formulation, RK, against phenylhydrazine-induced anemia in rats.

MATERIALS AND METHODS: RK was subjected to preliminary phytochemical analysis and iron estimation. Anemia was induced by phenylhydrazine administration (40 mg/kg, i.p.) for 2 consecutive days. Antianemic activity of RK was investigated at the dose of 1.8 ml/kg, twice daily for 12 days by estimating blood parameters and pathological changes in liver, heart, spleen and bone marrow.

RESULTS: RK was found to contain saponins, steroids, flavonoids, tannins and phenolic compounds. Iron content was found to be 5 mg/100 ml in RK. Anemia induction by phenylhydrazine injections to rats caused significant decrease in red blood cells (RBCs), hemoglobin and hematocrit. These decreased levels of RBCs, hemoglobin and hematocrit in blood was significantly improved by the treatment with RK. Furthermore, RK restored pathological changes in liver, heart, spleen and bone marrow tissues near to normal.

CONCLUSION: This study suggests antianemic activity of RK, which can be attributed to its iron content and ability to prevent hemolysis.

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Keywords: Anemia; Antianemic activity; Phenylhydrazine; Polyherbal formulation; RaktavardhakKadha

Conflict of interest statement

Conflict of interest None.

References

  1. Am J Trop Med Hyg. 2007 Jul;77(1):44-51 - PubMed
  2. Int J Clin Exp Pathol. 2014 Aug 15;7(9):6179-85 - PubMed
  3. Nature. 1975 Aug 21;256(5519):665-7 - PubMed
  4. Fitoterapia. 2008 Jul;79(5):332-6 - PubMed
  5. Braz J Med Biol Res. 2018 Oct 11;51(11):e7722 - PubMed
  6. Pharmacognosy Res. 2011 Apr;3(2):130-4 - PubMed

Publication Types