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Zhang Q, Tang X, Shen J. The efficacy and safety of low-molecular-weight heparin calcium combined with Xueshuantong injections in the treatment of elderly acute deep venous thrombosis patients. Am J Transl Res. 2021;13(4):3120-3128
Zhang, Q., Tang, X., & Shen, J. (2021). The efficacy and safety of low-molecular-weight heparin calcium combined with Xueshuantong injections in the treatment of elderly acute deep venous thrombosis patients. American journal of translational research, 13(4), 3120-3128.
Zhang, Qinguo, et al. "The efficacy and safety of low-molecular-weight heparin calcium combined with Xueshuantong injections in the treatment of elderly acute deep venous thrombosis patients." American journal of translational research vol. 13,4 (2021): 3120-3128.
Zhang Q, Tang X, Shen J. The efficacy and safety of low-molecular-weight heparin calcium combined with Xueshuantong injections in the treatment of elderly acute deep venous thrombosis patients. Am J Transl Res. 2021 Apr 15;13(4):3120-3128. eCollection 2021. PMID: 34017480; PMCID: PMC8129321.
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Am J Transl Res. 2021 Apr 15;13(4):3120-3128. eCollection 2021.

The efficacy and safety of low-molecular-weight heparin calcium combined with Xueshuantong injections in the treatment of elderly acute deep venous thrombosis patients.

American journal of translational research

Qinguo Zhang, Xuhua Tang, Jiang Shen

Affiliations

  1. Department of General Surgery, Zhuji Sixth People's Hospital Shaoxing, Zhejiang Province, China.
  2. Department of General Surgery, Zhuji People's Hospital of Zhejiang Province Shaoxing, Zhejiang Province, China.

PMID: 34017480 PMCID: PMC8129321

Abstract

OBJECTIVE: To explore the therapeutic effect of low-molecular-weight heparin calcium (LMWH-Ca) combined with Xueshuantong injections in treating elderly acute deep venous thrombosis (ADVT) patients, and to analyze the effect of this combination on the coagulation function, hemorheology, and safety.

METHODS: A total of 122 elderly patients with ADVT who were treated in our hospital were recruited as the study cohort. The patients were randomly divided into a control group (n=61) and an observation group (n=61). The patients in the control group were given abdominal subcutaneous injections of low-molecular-weight heparin calcium (LMWH-Ca). The patients in the observation group were given intravenous drips of LMWH-Ca (low-molecular-weight heparin calcium) and Xueshuantong injections. After the treatment, comparisons of the detumescence times of the affected limb, the differences in the circumferences of the lower limbs, the coagulation parameters, the overall response rates, the incidences of complications, and the hemorheological parameters were conducted between both groups.

RESULTS: After the treatment, the detumescence times and the average differences in the circumferences of the lower limbs were significantly reduced (P<0.001; all P<0.001), the prothrombin times (PT) and the activated partial thromboplastin times (APTT) were significantly extended (all P<0.01), the overall response rate was higher (all P<0.05), and the three hemorheological parameters (high shear viscosity, low shear viscosity, and plasma viscosity) were lower in the observation group than they were in the control group (all P<0.001), there were no statistical differences in the fibrinogen (FIB) levels, the incidences of complications, or the incidences of adverse drug reactions between the two groups (P>0.05; P=0.343; P=0.298).

CONCLUSION: To sum up, low-molecular-weight heparin combined with Xueshuantong injections can effectively treat elderly ADVT patients, reduce the differences in the circumferences of the lower limbs, regulate the coagulation function, and improve the blood viscosity, so it is worthy of clinical promotion.

AJTR Copyright © 2021.

Keywords: Low-molecular-weight heparin calcium; Xueshuantong injections; acute deep venous thrombosis; elderly patients

Conflict of interest statement

None.

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