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Clin Chem Lab Med. 2021 May 10;59(10):e392-e394. doi: 10.1515/cclm-2020-1884. Print 2021 Sep 27.

Development of chronic myeloid leukemia in a patient previously diagnosed with a JAK2-positive myeloproliferative neoplasm.

Clinical chemistry and laboratory medicine

Sander De Bruyne, Eva Steel, Marjan Petrick, Barbara Denys, Karl Vandepoele, Nadine Van Roy, Simon Degandt, Timothy Ghys, Henk Louagie

Affiliations

  1. Department of Laboratory Medicine, AZ Sint-Lucas, Ghent, Belgium.
  2. Department of Haematology, AZ Sint-Lucas, Ghent, Belgium.
  3. Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium.
  4. Department of Biomolecular Medicine, Ghent University Hospital, Ghent, Belgium.

PMID: 33964201 DOI: 10.1515/cclm-2020-1884

[No abstract available.]

Keywords: BCR-ABL1 ; JAK2 ; chronic myeloid leukemia; essential thrombocythemia; myeloproliferative neoplasm

References

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  2. Swerdlow, SH, Campo, E, Harris, NL, Jaffe, ES, Pileri, SA, Stein, H, et al.. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC; 2017. - PubMed
  3. Lorenzo, M, Grille, S, Stevenazzi, M. Emergence of BCR-ABL1 chronic myeloid leukemia in a JAK2-V617F polycythemia vera. J Hematol 2020;9:23–9. https://doi.org/10.14740/jh591. - PubMed
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  8. Scott, LM, Campbell, PJ, Baxter, EJ, Todd, T, Stephens, P, Edkins, S, et al.. The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders. Blood 2005;106:2920–1. https://doi.org/10.1182/blood-2005-05-2087. - PubMed
  9. Pardini, S, Fozza, C, Contini, S, Rimini, E, Ottaviani, E, Amabile, M, et al.. A case of coexistence between JAK2V617F and BCR/ABL. Eur J Haematol 2008;81:75–6. https://doi.org/10.1111/j.1600-0609.2008.01063.x. - PubMed
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