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Wen X, Yang Y, Klionsky DJ. Moments in autophagy and disease: Past and present. Mol Aspects Med. 2021;82:100966doi: 10.1016/j.mam.2021.100966.
Wen, X., Yang, Y., & Klionsky, D. J. (2021). Moments in autophagy and disease: Past and present. Molecular aspects of medicine, 82100966. https://doi.org/10.1016/j.mam.2021.100966
Wen, Xin, et al. "Moments in autophagy and disease: Past and present." Molecular aspects of medicine vol. 82 (2021): 100966. doi: https://doi.org/10.1016/j.mam.2021.100966
Wen X, Yang Y, Klionsky DJ. Moments in autophagy and disease: Past and present. Mol Aspects Med. 2021 Dec;82:100966. doi: 10.1016/j.mam.2021.100966. Epub 2021 Apr 28. PMID: 33931245; PMCID: PMC8548407.
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Mol Aspects Med. 2021 Dec;82:100966. doi: 10.1016/j.mam.2021.100966. Epub 2021 Apr 28.

Moments in autophagy and disease: Past and present.

Molecular aspects of medicine

Xin Wen, Ying Yang, Daniel J Klionsky

Affiliations

  1. Life Sciences Institute, Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
  2. Life Sciences Institute, Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address: [email protected].

PMID: 33931245 PMCID: PMC8548407 DOI: 10.1016/j.mam.2021.100966

Abstract

Over the past several decades, research on autophagy, a highly conserved lysosomal degradation pathway, has been advanced by studies in different model organisms, especially in the field of its molecular mechanism and regulation. The malfunction of autophagy is linked to various diseases, among which cancer and neurodegenerative diseases are the major focus. In this review, we cover some other important diseases, including cardiovascular diseases, infectious and inflammatory diseases, and metabolic disorders, as well as rare diseases, with a hope of providing a more complete understanding of the spectrum of autophagy's role in human health.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Autophagy; COVID-19; Cardiovascular diseases; Metabolic disorders; Rare diseases

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Grant support