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Laaksonen MA, Canfell K, MacInnis RJ, et al. The Future Burden of Head and Neck Cancers Attributable to Modifiable Behaviors in Australia: A Pooled Cohort Study. Cancer Epidemiol Biomarkers Prev. 2021;30(8):1566-1574doi: 10.1158/1055-9965.EPI-21-0003.
Laaksonen, M. A., Canfell, K., MacInnis, R. J., Banks, E., Byles, J. E., Giles, G. G., Magliano, D. J., Shaw, J. E., Hirani, V., Gill, T. K., Mitchell, P., Cumming, R. G., Salagame, U., & Vajdic, C. M. (2021). The Future Burden of Head and Neck Cancers Attributable to Modifiable Behaviors in Australia: A Pooled Cohort Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 30(8), 1566-1574. https://doi.org/10.1158/1055-9965.EPI-21-0003
Laaksonen, Maarit A, et al. "The Future Burden of Head and Neck Cancers Attributable to Modifiable Behaviors in Australia: A Pooled Cohort Study." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology vol. 30,8 (2021): 1566-1574. doi: https://doi.org/10.1158/1055-9965.EPI-21-0003
Laaksonen MA, Canfell K, MacInnis RJ, Banks E, Byles JE, Giles GG, Magliano DJ, Shaw JE, Hirani V, Gill TK, Mitchell P, Cumming RG, Salagame U, Vajdic CM. The Future Burden of Head and Neck Cancers Attributable to Modifiable Behaviors in Australia: A Pooled Cohort Study. Cancer Epidemiol Biomarkers Prev. 2021 Aug;30(8):1566-1574. doi: 10.1158/1055-9965.EPI-21-0003. Epub 2021 May 21. PMID: 34020998.
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Cancer Epidemiol Biomarkers Prev. 2021 Aug;30(8):1566-1574. doi: 10.1158/1055-9965.EPI-21-0003. Epub 2021 May 21.

The Future Burden of Head and Neck Cancers Attributable to Modifiable Behaviors in Australia: A Pooled Cohort Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Maarit A Laaksonen, Karen Canfell, Robert J MacInnis, Emily Banks, Julie E Byles, Graham G Giles, Dianna J Magliano, Jonathan E Shaw, Vasant Hirani, Tiffany K Gill, Paul Mitchell, Robert G Cumming, Usha Salagame, Claire M Vajdic

Affiliations

  1. School of Mathematics and Statistics, University of New South Wales, Sydney, Australia. [email protected].
  2. Daffodil Centre, The University of Sydney, a joint venture with Cancer Council New South Wales, Sydney, Australia.
  3. Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Australia.
  4. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
  5. ANU College of Medicine, Biology and Environment, Australian National University, Canberra, Australia.
  6. Research Centre for Generational Health and Ageing, University of Newcastle, Newcastle, Australia.
  7. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia.
  8. Diabetes and Population Health Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.
  9. Clinical Diabetes Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.
  10. School of Life and Environmental Sciences, Charles Perkins Centre, University of Sydney, Sydney, Australia.
  11. Adelaide Medical School, University of Adelaide, Adelaide, Australia.
  12. Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, Australia.
  13. School of Public Health, University of Sydney, Sydney, Australia.
  14. ANZAC Research Institute, University of Sydney and Concord Hospital, Sydney, Australia.
  15. Cancer Voices NSW, Sydney, Australia.
  16. Centre for Big Data Research in Health, University of New South Wales, Sydney, Australia.

PMID: 34020998 DOI: 10.1158/1055-9965.EPI-21-0003

Abstract

BACKGROUND: Estimates of future burden of cancer attributable to current modifiable causal exposures can guide cancer prevention. We quantified future head and neck cancer burden in Australia attributable to individual and joint causal exposures, and assessed whether these burdens differ between population subgroups.

METHODS: We estimated the strength of the associations between exposures and head and neck cancer using adjusted proportional hazards models from pooled data from seven Australian cohorts (

RESULTS: Contemporary levels of current and former smoking contribute 30.6% (95% CI, 22.7%-37.8%), alcohol consumption exceeding two standard drinks per day 12.9% (95% CI, 7.6%-17.9%), and these exposures jointly 38.5% (95% CI, 31.1%-45.0%) to the future head and neck cancer burden. Alcohol-attributable burden is triple and smoking-attributable burden is double for men compared with women. Smoking-attributable burden is also at least double for those consuming more than two alcoholic drinks daily or doing less than 150 minutes of moderate or 75 minutes of vigorous activity weekly, and for those aged under 65 years, unmarried, with low or intermediate educational attainment or lower socioeconomic status, compared with their counterparts.

CONCLUSIONS: Two-fifths of head and neck cancers in Australia are preventable by investment in tobacco and alcohol control.

IMPACT: Targeting men and other identified high-burden subgroups can help to reduce head and neck cancer burden disparities.

©2021 American Association for Cancer Research.

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