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Kochergin-Nikitsky K, Belova L, Lavrov A, et al. Tissue and cell-type-specific transduction using rAAV vectors in lung diseases. J Mol Med (Berl). 2021;99(8):1057-1071doi: 10.1007/s00109-021-02086-y.
Kochergin-Nikitsky, K., Belova, L., Lavrov, A., & Smirnikhina, S. (2021). Tissue and cell-type-specific transduction using rAAV vectors in lung diseases. Journal of molecular medicine (Berlin, Germany), 99(8), 1057-1071. https://doi.org/10.1007/s00109-021-02086-y
Kochergin-Nikitsky, Konstantin, et al. "Tissue and cell-type-specific transduction using rAAV vectors in lung diseases." Journal of molecular medicine (Berlin, Germany) vol. 99,8 (2021): 1057-1071. doi: https://doi.org/10.1007/s00109-021-02086-y
Kochergin-Nikitsky K, Belova L, Lavrov A, Smirnikhina S. Tissue and cell-type-specific transduction using rAAV vectors in lung diseases. J Mol Med (Berl). 2021 Aug;99(8):1057-1071. doi: 10.1007/s00109-021-02086-y. Epub 2021 May 21. PMID: 34021360.
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J Mol Med (Berl). 2021 Aug;99(8):1057-1071. doi: 10.1007/s00109-021-02086-y. Epub 2021 May 21.

Tissue and cell-type-specific transduction using rAAV vectors in lung diseases.

Journal of molecular medicine (Berlin, Germany)

Konstantin Kochergin-Nikitsky, Lyubava Belova, Alexander Lavrov, Svetlana Smirnikhina

Affiliations

  1. Research Center for Medical Genetics, 115478, Moscow, Russia. [email protected].
  2. Research Center for Medical Genetics, 115478, Moscow, Russia.

PMID: 34021360 DOI: 10.1007/s00109-021-02086-y

Abstract

Gene therapy of genetically determined diseases, including some pathologies of the respiratory system, requires an efficient method for transgene delivery. Recombinant adeno-associated viral (rAAV) vectors are well studied and employed in gene therapy, as they are relatively simple and low immunogenic and able to efficiently transduce eukaryotic cells. To date, many natural and artificial (with modified capsids) AAV serotypes have been isolated, demonstrating preferential tropism toward different tissues and cells in accordance with the prevalent receptors on the cell surface. However, rAAV-mediated delivery is not strictly specific due to wide tropism of some viral serotypes. Thus, the development of the methods allowing modulating specificity of these vectors could be beneficial in some cases. This review describes various approaches for retargeting rAAV to respiratory cells, for example, using different types of capsid modifications and regulation of a transgene expression by tissue-specific promoters. Part of the review is devoted to the issues of transduction of stem and progenitor lung cells using AAV, which is a complicated task today.

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords: Adeno-associated virus; Cystic fibrosis; Lung airway mucus; Recombinant capsids; Stem cells; Tissue-specific promoters

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