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Natori Y, Anjan S, Martin EF, et al. When is it safe to perform abdominal transplantation in patients with prior SARS-CoV-2 infection: A case series. Clin Transplant. 2021;e14370doi: 10.1111/ctr.14370.
Natori, Y., Anjan, S., Martin, E. F., Selvagi, G., Villavicencio, A., Coro, A., Mendez-Castaner, L. A., Mattiazzi, A., Pagan, J., Ortigosa-Goggins, M., Roth, D., Kupin, W., O'Brien, C. B., Arosemena, L. R., Ciancio, G., Burke, G. W., Morsi, M., Figueiro, J. M., Chen, L., Tekin, A., Miyashiro, R., Simkins, J., Abbo, L. M., Vianna, R. M., & Guerra, G. (2021). When is it safe to perform abdominal transplantation in patients with prior SARS-CoV-2 infection: A case series. Clinical transplantation, e14370. https://doi.org/10.1111/ctr.14370
Natori, Yoichiro, et al. "When is it safe to perform abdominal transplantation in patients with prior SARS-CoV-2 infection: A case series." Clinical transplantation vol. (2021): e14370. doi: https://doi.org/10.1111/ctr.14370
Natori Y, Anjan S, Martin EF, Selvagi G, Villavicencio A, Coro A, Mendez-Castaner LA, Mattiazzi A, Pagan J, Ortigosa-Goggins M, Roth D, Kupin W, O'Brien CB, Arosemena LR, Ciancio G, Burke GW, Morsi M, Figueiro JM, Chen L, Tekin A, Miyashiro R, Simkins J, Abbo LM, Vianna RM, Guerra G. When is it safe to perform abdominal transplantation in patients with prior SARS-CoV-2 infection: A case series. Clin Transplant. 2021 May 25;e14370. doi: 10.1111/ctr.14370. Epub 2021 May 25. PMID: 34032328; PMCID: PMC8209911.
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Clin Transplant. 2021 May 25;e14370. doi: 10.1111/ctr.14370. Epub 2021 May 25.

When is it safe to perform abdominal transplantation in patients with prior SARS-CoV-2 infection: A case series.

Clinical transplantation

Yoichiro Natori, Shweta Anjan, Eric F Martin, Gennaro Selvagi, Aasith Villavicencio, Ana Coro, Lumen A Mendez-Castaner, Adela Mattiazzi, Javier Pagan, Mariella Ortigosa-Goggins, David Roth, Warren Kupin, Christopher B O'Brien, Leopoldo R Arosemena, Gaetano Ciancio, George W Burke, Mahmoud Morsi, Jose M Figueiro, Linda Chen, Akin Tekin, Rafael Miyashiro, Jacques Simkins, Lilian M Abbo, Rodrigo M Vianna, Giselle Guerra

Affiliations

  1. Miami Transplant Institute, Jackson Health System, Miami, FL, USA.
  2. Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA.
  3. Department of Medicine, Division of Hepatology, University of Miami Miller School of Medicine, Miami, FL, USA.
  4. Department of Medicine, Division of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  5. Department of Medicine, Division of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
  6. Department of Medicine, Division of Nephrology, University of Miami Miller School of Medicine, Miami, FL, USA.

PMID: 34032328 PMCID: PMC8209911 DOI: 10.1111/ctr.14370

Abstract

BACKGROUND: The Coronavirus disease 2019(COVID-19) pandemic has negatively impacted worldwide organ transplantation. However, there is limited information on recipients transplanted after SARS-CoV-2 infection. A full understanding of this scenario is required, as transplantation is a life-saving procedure and COVID-19 remains an ongoing threat.

METHODS: Abdominal organ transplant recipients diagnosed with COVID-19 prior to transplantation were identified by chart review and clinical data were collected. The primary outcome was the transplant outcome including graft loss, rejection and death, and reactivation of infection post-transplant.

RESULTS: We identified 14 patients who received abdominal organ transplants after symptomatic PCR confirmed SARS-CoV-2 infection; four patients had a positive PCR at the time of admission for transplantation. The median time of follow-up was 79 (22-190) days. One recipient with negative PCR before transplant tested positive 9 days after transplant. One of 14 transplanted patients developed disseminated mold infection and died 86 days after transplant. During the follow-up, only one patient developed rejection; thirteen patients had favorable graft outcomes.

CONCLUSIONS: We were able to perform abdominal transplantation for patients with COVID-19 before transplant, even with positive PCR at the time of transplant. Larger studies are needed to determine the time to safe transplant after SARS-CoV-2 infection.

© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Keywords: PCR; abdominal transplantation; coronavirus disease 2019

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