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Matos B, Publicover SJ, Castro LFC, et al. Brain and testis: more alike than previously thought?. Open Biol. 2021;11(6):200322doi: 10.1098/rsob.200322.
Matos, B., Publicover, S. J., Castro, L. F. C., Esteves, P. J., & Fardilha, M. (2021). Brain and testis: more alike than previously thought?. Open biology, 11(6), 200322. https://doi.org/10.1098/rsob.200322
Matos, Bárbara, et al. "Brain and testis: more alike than previously thought?." Open biology vol. 11,6 (2021): 200322. doi: https://doi.org/10.1098/rsob.200322
Matos B, Publicover SJ, Castro LFC, Esteves PJ, Fardilha M. Brain and testis: more alike than previously thought?. Open Biol. 2021 Jun;11(6):200322. doi: 10.1098/rsob.200322. Epub 2021 Jun 02. PMID: 34062096; PMCID: PMC8169208.
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Open Biol. 2021 Jun;11(6):200322. doi: 10.1098/rsob.200322. Epub 2021 Jun 02.

Brain and testis: more alike than previously thought?.

Open biology

Bárbara Matos, Stephen J Publicover, Luis Filipe C Castro, Pedro J Esteves, Margarida Fardilha

Affiliations

  1. Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine-iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal.
  2. School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  3. CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Porto, Portugal.
  4. Department of Biology, FCUP-Faculty of Sciences, University of Porto, Porto, Portugal.
  5. CIBIO-InBIO, Research Centre in Biodiversity and Genetic Resources, Campus Agrico de Vairão, University of Porto, 4485-661 Vairão, Portugal.

PMID: 34062096 PMCID: PMC8169208 DOI: 10.1098/rsob.200322

Abstract

Several strands of evidence indicate the presence of marked similarities between human brain and testis. Understanding these similarities and their implications has become a topic of interest among the scientific community. Indeed, an association of intelligence with some semen quality parameters has been reported and a relation between dysfunctions of the human brain and testis has also been evident. Numerous common molecular features are evident when these tissues are compared, which is reflected in the huge number of common proteins. At the functional level, human neurons and sperm share a number of characteristics, including the importance of the exocytotic process and the presence of similar receptors and signalling pathways. The common proteins are mainly involved in exocytosis, tissue development and neuron/brain-associated biological processes. With this analysis, we conclude that human brain and testis share several biochemical characteristics which, in addition to their involvement in the speciation process, could, at least in part, be responsible for the expression of a huge number of common proteins. Nonetheless, this is an underexplored topic, and the connection between these tissues needs to be clarified, which could help to understand the dysfunctions affecting brain and testis, as well as to develop improved therapeutic strategies.

Keywords: brain; molecular; neuron; sperm; testis

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