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Yan Y, Lei G, Gan B. A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis. Mol Cell Oncol. 2021;8(3):1919006doi: 10.1080/23723556.2021.1919006.
Yan, Y., Lei, G., & Gan, B. (2021). A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis. Molecular & cellular oncology, 8(3), 1919006. https://doi.org/10.1080/23723556.2021.1919006
Yan, Yuelong, et al. "A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis." Molecular & cellular oncology vol. 8,3 (2021): 1919006. doi: https://doi.org/10.1080/23723556.2021.1919006
Yan Y, Lei G, Gan B. A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis. Mol Cell Oncol. 2021 Apr 27;8(3):1919006. doi: 10.1080/23723556.2021.1919006. eCollection 2021. PMID: 34027051; PMCID: PMC8128196.
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Mol Cell Oncol. 2021 Apr 27;8(3):1919006. doi: 10.1080/23723556.2021.1919006. eCollection 2021.

A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis.

Molecular & cellular oncology

Yuelong Yan, Guang Lei, Boyi Gan

Affiliations

  1. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  2. The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.

PMID: 34027051 PMCID: PMC8128196 DOI: 10.1080/23723556.2021.1919006

Abstract

Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 (mTORC1) axis, and proposed that co-targeting mTORC1 and ferroptosis is a promising strategy for cancer therapy.

© 2021 Taylor & Francis Group, LLC.

Keywords: GPX4; SLC7A11; cancer therapy; cysteine; cystine; ferroptosis; lipid peroxidation; mTORC1

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