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Mustonen AM, Käkelä R, Joukainen A, et al. Synovial Fluid Fatty Acid Profiles Are Differently Altered by Inflammatory Joint Pathologies in the Shoulder and Knee Joints. Biology (Basel). 2021;10(5)doi: 10.3390/biology10050401.
Mustonen, A. M., Käkelä, R., Joukainen, A., Lehenkari, P., Jaroma, A., Kääriäinen, T., Kröger, H., Paakkonen, T., Sihvo, S. P., & Nieminen, P. (2021). Synovial Fluid Fatty Acid Profiles Are Differently Altered by Inflammatory Joint Pathologies in the Shoulder and Knee Joints. Biology, 10(5), . https://doi.org/10.3390/biology10050401
Mustonen, Anne-Mari, et al. "Synovial Fluid Fatty Acid Profiles Are Differently Altered by Inflammatory Joint Pathologies in the Shoulder and Knee Joints." Biology vol. 10,5 (2021). doi: https://doi.org/10.3390/biology10050401
Mustonen AM, Käkelä R, Joukainen A, Lehenkari P, Jaroma A, Kääriäinen T, Kröger H, Paakkonen T, Sihvo SP, Nieminen P. Synovial Fluid Fatty Acid Profiles Are Differently Altered by Inflammatory Joint Pathologies in the Shoulder and Knee Joints. Biology (Basel). 2021 May 04;10(5). doi: 10.3390/biology10050401. PMID: 34064447; PMCID: PMC8147852.
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Biology (Basel). 2021 May 04;10(5). doi: 10.3390/biology10050401.

Synovial Fluid Fatty Acid Profiles Are Differently Altered by Inflammatory Joint Pathologies in the Shoulder and Knee Joints.

Biology

Anne-Mari Mustonen, Reijo Käkelä, Antti Joukainen, Petri Lehenkari, Antti Jaroma, Tommi Kääriäinen, Heikki Kröger, Tommi Paakkonen, Sanna P Sihvo, Petteri Nieminen

Affiliations

  1. Institute of Biomedicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
  2. Department of Environmental and Biological Sciences, Faculty of Science and Forestry, University of Eastern Finland, P.O. Box 111, FI-80101 Joensuu, Finland.
  3. Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, P.O. Box 65, FI-00014 Helsinki, Finland.
  4. Helsinki University Lipidomics Unit (HiLIPID), Helsinki Institute for Life Science (HiLIFE) and Biocenter Finland, University of Helsinki, P.O. Box 65, FI-00014 Helsinki, Finland.
  5. Pohjola Hospital, Leväsentie 1, FI-70700 Kuopio, Finland.
  6. Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland.
  7. Department of Surgery and Medical Research Center, Oulu University Hospital, P.O. Box 21, FI-90029 OYS, Finland.
  8. Department of Orthopaedics, Traumatology and Hand Surgery, Kuopio University Hospital, P.O. Box 100, FI-70290 Kuopio, Finland.

PMID: 34064447 PMCID: PMC8147852 DOI: 10.3390/biology10050401

Abstract

Anomalies of fatty acid (FA) metabolism characterize osteoarthritis (OA) and rheumatoid arthritis (RA) in the knee joint. No previous study has investigated the synovial fluid (SF) FA manifestations in these aging-related inflammatory diseases in the shoulder. The present experiment compared the FA alterations between the shoulder and knee joints in patients with end-stage OA or end-stage RA. SF samples were collected during glenohumeral or knee joint surgery from trauma controls and from OA and RA patients (n = 42). The FA composition of SF total lipids was analyzed by gas chromatography with flame ionization and mass spectrometric detection and compared across cohorts. The FA signatures of trauma controls were mostly uniform in both anatomical locations. RA shoulders were characterized by elevated percentages of 20:4n-6 and 22:6n-3 and with reduced proportions of 18:1n-9. The FA profiles of OA and RA knees were relatively uniform and displayed lower proportions of 18:2n-6, 22:6n-3 and total n-6 polyunsaturated FAs (PUFAs). The results indicate location- and disease-dependent differences in the SF FA composition. These alterations in FA profiles and their potential implications for the production of PUFA-derived lipid mediators may affect joint lubrication, synovial inflammation and pannus formation as well as cartilage and bone degradation and contribute to the pathogeneses of inflammatory joint diseases.

Keywords: fatty acid; knee; n-3 polyunsaturated fatty acids; n-6 polyunsaturated fatty acids; osteoarthritis; rheumatoid arthritis; shoulder; synovial fluid

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