Display options
Cite
Ghods S, Khalili Pour E, Riazi-Esfahani H, et al. Closantel Retinal Toxicity: Case Report and Literature Review. Case Rep Ophthalmol Med. 2021;2021:4832965doi: 10.1155/2021/4832965.
Ghods, S., Khalili Pour, E., Riazi-Esfahani, H., Faghihi, H., & Inanloo, B. (2021). Closantel Retinal Toxicity: Case Report and Literature Review. Case reports in ophthalmological medicine, 20214832965. https://doi.org/10.1155/2021/4832965
Ghods, Sepideh, et al. "Closantel Retinal Toxicity: Case Report and Literature Review." Case reports in ophthalmological medicine vol. 2021 (2021): 4832965. doi: https://doi.org/10.1155/2021/4832965
Ghods S, Khalili Pour E, Riazi-Esfahani H, Faghihi H, Inanloo B. Closantel Retinal Toxicity: Case Report and Literature Review. Case Rep Ophthalmol Med. 2021 May 21;2021:4832965. doi: 10.1155/2021/4832965. eCollection 2021. PMID: 34094608; PMCID: PMC8163541.
Copy Download .nbib Format: NLM
Share it on

Case Rep Ophthalmol Med. 2021 May 21;2021:4832965. doi: 10.1155/2021/4832965. eCollection 2021.

Closantel Retinal Toxicity: Case Report and Literature Review.

Case reports in ophthalmological medicine

Sepideh Ghods, Elias Khalili Pour, Hamid Riazi-Esfahani, Hooshang Faghihi, Bahman Inanloo

Affiliations

  1. Retina Ward, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 34094608 PMCID: PMC8163541 DOI: 10.1155/2021/4832965

Abstract

A 57-year-old shepherd was referred with a 2-week history of decreased visual acuity in both eyes. Optical coherence tomography (OCT) (Heidelberg Engineering GmbH, Heidelberg, Germany) revealed diffuse outer nuclear layer hyperreflectivity and indistinguishable external limiting membrane and ellipsoid zone. The patient announced to us that he took two 500 mg of closantel tablets (15.15 mg/kg) three days before the initiation of visual problems for sore throat as an antibiotic. Electroretinography displayed severely attenuated responses in both eyes. We decided to admit the patient with the presumed diagnosis of closantel retinal toxicity and treated him with intravenous methylprednisolone 1 g per day and intravenous erythropoietin 10000 IU twice a day, and reevaluation of the patient proved no change in his visual acuity on the third day of admission. Closantel is a veterinary drug with serious side effects in the human retina and central nervous system even in previously reported doses. Public awareness and appropriate drug labeling about its side effects could prevent accidental toxicity. OCT is a noninvasive and rapid diagnostic modality that should be done in suspected toxic retinopathy.

Copyright © 2021 Sepideh Ghods et al.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

References

  1. World Health Organ Tech Rep Ser. 2006;(939):1-80, backcover - PubMed
  2. JAMA Ophthalmol. 2015 Jun;133(6):718-20 - PubMed
  3. Lancet. 1993 Jul 31;342(8866):308-9 - PubMed
  4. BMC Ophthalmol. 2021 Mar 31;21(1):158 - PubMed
  5. J Vet Pharmacol Ther. 1998 Jun;21(3):190-8 - PubMed
  6. Eye (Lond). 2018 Dec;32(12):1800-1802 - PubMed
  7. Vet Hum Toxicol. 1999 Dec;41(6):378-80 - PubMed
  8. BMC Ophthalmol. 2016 Nov 29;16(1):207 - PubMed
  9. J Comp Pathol. 2007 Feb-Apr;136(2-3):87-95 - PubMed
  10. Aust Vet J. 1999 Apr;77(4):259-61 - PubMed
  11. Drug Metab Rev. 1987;18(2-3):235-51 - PubMed

Publication Types