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Kiuchi S, Ihara H, Osawa S, et al. A survey of the reactivity of . Ann Clin Biochem. 2021;58(6):563-571doi: 10.1177/00045632211026699.
Kiuchi, S., Ihara, H., Osawa, S., Ishibashi, M., Kinpara, K., Ohtake, K., Ida, T., Miura, Y., Fujimura, Y., Ueda, S., Hirano, Y., Watahiki, K., Takada, D., Shinzaki, A., Tanimoto, K., Adachi, H., Nejime, T., Totani, M., Itoh, S. (2021). A survey of the reactivity of . Annals of clinical biochemistry, 58(6), 563-571. https://doi.org/10.1177/00045632211026699
Kiuchi, Sachiko, et al. "A survey of the reactivity of ." Annals of clinical biochemistry vol. 58,6 (2021): 563-571. doi: https://doi.org/10.1177/00045632211026699
Kiuchi S, Ihara H, Osawa S, Ishibashi M, Kinpara K, Ohtake K, Ida T, Miura Y, Fujimura Y, Ueda S, Hirano Y, Watahiki K, Takada D, Shinzaki A, Tanimoto K, Adachi H, Nejime T, Totani M, Itoh S. A survey of the reactivity of . Ann Clin Biochem. 2021 Nov;58(6):563-571. doi: 10.1177/00045632211026699. Epub 2021 Jul 04. PMID: 34120480.
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Ann Clin Biochem. 2021 Nov;58(6):563-571. doi: 10.1177/00045632211026699. Epub 2021 Jul 04.

A survey of the reactivity of .

Annals of clinical biochemistry

Sachiko Kiuchi, Hiroshi Ihara, Susumu Osawa, Midori Ishibashi, Kiyoko Kinpara, Kazuko Ohtake, Takehisa Ida, Yoshinori Miura, Yoshiyuki Fujimura, Shigeru Ueda, Yuuki Hirano, Kensuke Watahiki, Daiichiro Takada, Akihiro Shinzaki, Kazuhito Tanimoto, Hiroshi Adachi, Tetsuya Nejime, Masayuki Totani, Susumu Itoh,

Affiliations

  1. Faculty of Risk and Crisis Management, Chiba Institute of Science, Chiba, Japan.
  2. Medical laboratory Sciences, Health Sciences, International University of Health and Welfare Graduate School, Chiba, Japan.
  3. Clinical Laboratory, New Tokyo Hospital, Chiba, Japan.
  4. Department of Clinical Laboratory, Toranomon Hospital, Tokyo, Japan.
  5. Department of Laboratory Medicine, Keio University Hospital, Tokyo, Japan.
  6. Central Laboratory, Saiseikai Chuwa Hospital, Nara, Japan.
  7. Department of Clinical Laboratory, Kitasato University Hospital, Kanagawa, Japan.
  8. LSI Medience Corporation, Tokyo, Japan.
  9. Eiken Chemical Co., Ltd, Tokyo, Japan.
  10. Nittobo Medical Co., Ltd, Tokyo, Japan.
  11. Nipro Corporation, Osaka, Japan.
  12. Fujifilm Wako Pure Chemical Corporation, Osaka, Japan.
  13. Alfresa Pharma Corporation, Osaka, Japan.
  14. Serotec Co., Ltd, Hokkaido, Japan.
  15. National Institute of Health and Nutrition, Tokyo, Japan.
  16. Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.

PMID: 34120480 DOI: 10.1177/00045632211026699

Abstract

METHODS: Porcine unconjugated bilirubin solution, chemically synthesized ditaurobilirubin solution, and chemically synthesized delta bilirubin solution were used as surrogates of naturally occurring unconjugated bilirubin, conjugated bilirubin, and delta bilirubin, respectively. The total bilirubin and direct-reacting bilirubin concentrations were measured by three bilirubin oxidase methods and one vanadic acid method, and the observed concentrations were compared with those obtained by the diazo-based reference measurement procedure.

RESULTS: The unconjugated bilirubin and delta bilirubin concentrations were similar when any of the four

CONCLUSIONS: We revealed the reactivity of IVD-TB and IVD-DB reagents to artificially prepared bilirubin materials, and their consistency with reference measurement procedure. The delta bilirubin data results vary depending on the reagents used.

Keywords: Total and direct-reacting bilirubin; bilirubin oxidase; delta bilirubin; unconjugated and conjugated bilirubin; vanadate oxidation

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