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Chung JY, Lee SJ, Lee HJ, et al. Aconitine Neurotoxicity According to Administration Methods. J Clin Med. 2021;10(10)doi: 10.3390/jcm10102149.
Chung, J. Y., Lee, S. J., Lee, H. J., Bong, J. B., Lee, C. H., Shin, B. S., & Kang, H. G. (2021). Aconitine Neurotoxicity According to Administration Methods. Journal of clinical medicine, 10(10), . https://doi.org/10.3390/jcm10102149
Chung, Ji Yeon, et al. "Aconitine Neurotoxicity According to Administration Methods." Journal of clinical medicine vol. 10,10 (2021). doi: https://doi.org/10.3390/jcm10102149
Chung JY, Lee SJ, Lee HJ, Bong JB, Lee CH, Shin BS, Kang HG. Aconitine Neurotoxicity According to Administration Methods. J Clin Med. 2021 May 16;10(10). doi: 10.3390/jcm10102149. PMID: 34065630; PMCID: PMC8155921.
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J Clin Med. 2021 May 16;10(10). doi: 10.3390/jcm10102149.

Aconitine Neurotoxicity According to Administration Methods.

Journal of clinical medicine

Ji Yeon Chung, Seung Jae Lee, Hyuck Jin Lee, Jeong Bin Bong, Chan-Hyuk Lee, Byoung-Soo Shin, Hyun Goo Kang

Affiliations

  1. Department of Neurology, Chosun University Hospital, Gwang-ju 61453, Korea.
  2. Department of Chemistry and Institute of Molecular Biology and Genetics, Jeonbuk National University, Jeonju 54907, Korea.
  3. Department of Chemistry Education, Kongju National University, Gongju 32588, Korea.
  4. Department of Neurology, Jeonbuk National University Medical School, Jeonju 54907, Korea.
  5. Department of Neurology, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea.

PMID: 34065630 PMCID: PMC8155921 DOI: 10.3390/jcm10102149

Abstract

We evaluated the toxic effects of aconitine on the human nervous system and its associated factors, and the general clinical characteristics of patients who visited the emergency room due to aconitine intoxication between 2008 and 2017. We also analyzed the differences related to aconitine processing and administration methods (oral pill, boiled in water, and alcohol-soaked), and the clinical characteristics of consciousness deterioration and neurological symptoms. Of the 41 patients who visited the hospital due to aconitine intoxication, 23 (56.1%) were female, and most were older. Aconitine was mainly used for pain control (28 patients, 68.3%) and taken as oral pills (19 patients, 46%). The patients showed a single symptom or a combination of symptoms; neurological symptoms were the most common (21 patients). All patients who took aconitine after processing with alcohol showed neurological symptoms and a higher prevalence of consciousness deterioration. Neurological symptoms occurred most frequently in patients with aconitine intoxication. Although aconitine intoxication presents with various symptoms, its prognosis may vary with the processing method and prevalence of consciousness deterioration during the early stages. Therefore, the administration method and accompanying symptoms should be comprehensively investigated in patients who have taken aconitine to facilitate prompt and effective treatment and better prognoses.

Keywords: aconitine; alcohol; intoxication; mechanism; neurotoxicity

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