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Hering D, Hubbard BS, Weber MA, et al. Impact of Renal Pelvic Denervation on Systemic Hemodynamics and Neurohumoral Changes in a Porcine Model. Am J Nephrol. 2021;52(5):429-434doi: 10.1159/000516186.
Hering, D., Hubbard, B. S., Weber, M. A., & Heuser, R. R. (2021). Impact of Renal Pelvic Denervation on Systemic Hemodynamics and Neurohumoral Changes in a Porcine Model. American journal of nephrology, 52(5), 429-434. https://doi.org/10.1159/000516186
Hering, Dagmara, et al. "Impact of Renal Pelvic Denervation on Systemic Hemodynamics and Neurohumoral Changes in a Porcine Model." American journal of nephrology vol. 52,5 (2021): 429-434. doi: https://doi.org/10.1159/000516186
Hering D, Hubbard BS, Weber MA, Heuser RR. Impact of Renal Pelvic Denervation on Systemic Hemodynamics and Neurohumoral Changes in a Porcine Model. Am J Nephrol. 2021;52(5):429-434. doi: 10.1159/000516186. Epub 2021 May 26. PMID: 34038910.
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Am J Nephrol. 2021;52(5):429-434. doi: 10.1159/000516186. Epub 2021 May 26.

Impact of Renal Pelvic Denervation on Systemic Hemodynamics and Neurohumoral Changes in a Porcine Model.

American journal of nephrology

Dagmara Hering, Brad S Hubbard, Michael A Weber, Richard R Heuser

Affiliations

  1. Arizona State University, Tempe, Arizona, USA.
  2. Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland.
  3. WestPoint Innovation Center, Chengdu, China.
  4. State University of New York, Downstate Medical Center, New York, New York, USA.
  5. University of Arizona College of Medicine, Phoenix, Arizona, USA.

PMID: 34038910 DOI: 10.1159/000516186

Abstract

INTRODUCTION: The blood pressure (BP) response to arterial renal denervation (RDN) is variable.

METHODS: This study examined the effectiveness of renal pelvic denervation (RPD) on BP, heart rate (HR), norepinephrine (NE), and histopathology in 42 swine. NE levels were measured immediately, 7, 14, 30, and 90 days after RPD. Intra-arterial BP and HR were measured throughout RPD and after 14 days in 5 swine.

RESULTS: During the procedure, RPD immediately reduced systolic BP (-20.6 ± 18.3 mm Hg), diastolic BP (-6.0 ± 8.3 mm Hg), and HR (-5.4 ± 5.6 bpm), which remained decreased at follow-up. The porcine kidneys had a mean NE reduction of 76% directly post procedure and 60% after 7 days, 64% after 14 days, 57% after 30 days, and 65% after 90 days. Histopathological examination confirmed nerve ablation.

CONCLUSIONS: These preliminary findings suggest that the renal pelvis nerve ablation is an encouraging target for RDN. Clinical trials are required to test the feasibility of RPD in human hypertension.

© 2021 S. Karger AG, Basel.

Keywords: Blood pressure; Heart rate; Hypertension; Norepinephrine; Porcine model; Transurethral renal nerve ablation

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