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Georgaki M, Avgoustidis D, Theofilou VI, et al. Recurrence in Oral Premalignancy: Clinicopathologic and Immunohistochemical Analysis. Diagnostics (Basel). 2021;11(5)doi: 10.3390/diagnostics11050872.
Georgaki, M., Avgoustidis, D., Theofilou, V. I., Piperi, E., Pettas, E., Kalyvas, D. G., Vlachodimitropoulos, D., Perisanidis, C., Lazaris, A. C., & Nikitakis, N. G. (2021). Recurrence in Oral Premalignancy: Clinicopathologic and Immunohistochemical Analysis. Diagnostics (Basel, Switzerland), 11(5), . https://doi.org/10.3390/diagnostics11050872
Georgaki, Maria, et al. "Recurrence in Oral Premalignancy: Clinicopathologic and Immunohistochemical Analysis." Diagnostics (Basel, Switzerland) vol. 11,5 (2021). doi: https://doi.org/10.3390/diagnostics11050872
Georgaki M, Avgoustidis D, Theofilou VI, Piperi E, Pettas E, Kalyvas DG, Vlachodimitropoulos D, Perisanidis C, Lazaris AC, Nikitakis NG. Recurrence in Oral Premalignancy: Clinicopathologic and Immunohistochemical Analysis. Diagnostics (Basel). 2021 May 12;11(5). doi: 10.3390/diagnostics11050872. PMID: 34066207; PMCID: PMC8151734.
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Diagnostics (Basel). 2021 May 12;11(5). doi: 10.3390/diagnostics11050872.

Recurrence in Oral Premalignancy: Clinicopathologic and Immunohistochemical Analysis.

Diagnostics (Basel, Switzerland)

Maria Georgaki, Dimitris Avgoustidis, Vasileios Ionas Theofilou, Evangelia Piperi, Efstathios Pettas, Demos G Kalyvas, Dimitrios Vlachodimitropoulos, Christos Perisanidis, Andreas C Lazaris, Nikolaos G Nikitakis

Affiliations

  1. Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  2. Department of Oral and Maxillofacial Surgery, "Evaggelismos" General Hospital, School of Dentistry, National and Kapodistrian University of Athens, 10676 Athens, Greece.
  3. Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA.
  4. Department of Oral & Maxillofacial Surgery, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  5. Department of Forensic Medicine-Toxicology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  6. Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.

PMID: 34066207 PMCID: PMC8151734 DOI: 10.3390/diagnostics11050872

Abstract

Oral leukoplakia (OL) has a propensity for recurrence and malignant transformation (MT). Herein, we evaluate sociodemographic, clinical, microscopic and immunohistochemical parameters as predictive factors for OL recurrence, also comparing primary lesions (PLs) with recurrences. Thirty-three patients with OL, completely removed either by excisional biopsy or by laser ablation following incisional biopsy, were studied. Selected molecules associated with the STAT3 oncogenic pathway, including pSTAT3, Bcl-xL, survivin, cyclin D1 and Ki-67, were further analyzed. A total of 135 OL lesions, including 97 PLs and 38 recurrences, were included. Out of 97 PLs, 31 recurred at least once and none of them underwent MT, during a mean follow-up time of 48.3 months. There was no statistically significant difference among the various parameters in recurrent vs. non-recurrent PLs, although recurrence was most frequent in non-homogeneous lesions (

Keywords: Bcl-xL; Ki-67; STAT3; cyclin D1; laser ablation; oral leukoplakia; oral potentially malignant disorders; predictive biomarkers; recurrence; survivin

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