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George EA, Baranwal N, Kang JH, et al. Photosensitizing Medications and Skin Cancer: A Comprehensive Review. Cancers (Basel). 2021;13(10)doi: 10.3390/cancers13102344.
George, E. A., Baranwal, N., Kang, J. H., Qureshi, A. A., Drucker, A. M., & Cho, E. (2021). Photosensitizing Medications and Skin Cancer: A Comprehensive Review. Cancers, 13(10), . https://doi.org/10.3390/cancers13102344
George, Elisabeth A, et al. "Photosensitizing Medications and Skin Cancer: A Comprehensive Review." Cancers vol. 13,10 (2021). doi: https://doi.org/10.3390/cancers13102344
George EA, Baranwal N, Kang JH, Qureshi AA, Drucker AM, Cho E. Photosensitizing Medications and Skin Cancer: A Comprehensive Review. Cancers (Basel). 2021 May 12;13(10). doi: 10.3390/cancers13102344. PMID: 34066301; PMCID: PMC8152064.
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Cancers (Basel). 2021 May 12;13(10). doi: 10.3390/cancers13102344.

Photosensitizing Medications and Skin Cancer: A Comprehensive Review.

Cancers

Elisabeth A George, Navya Baranwal, Jae H Kang, Abrar A Qureshi, Aaron M Drucker, Eunyoung Cho

Affiliations

  1. Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
  2. Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  3. Department of Dermatology, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
  4. Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02903, USA.
  5. Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON M5S 3H2, Canada.
  6. Women's College Research Institute and Division of Dermatology, Department of Medicine, Women's College Hospital, Toronto, ON M5S 1B2, Canada.
  7. Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.

PMID: 34066301 PMCID: PMC8152064 DOI: 10.3390/cancers13102344

Abstract

(1) The incidence of skin cancer is increasing in the United States (US) despite scientific advances in our understanding of skin cancer risk factors and treatments. In vitro and in vivo studies have provided evidence that suggests that certain photosensitizing medications (PSMs) increase skin cancer risk. This review summarizes current epidemiological evidence on the association between common PSMs and skin cancer. (2) A comprehensive literature search was conducted to identify meta-analyses, observational studies and clinical trials that report on skin cancer events in PSM users. The associated risks of keratinocyte carcinoma (squamous cell carcinoma and basal cell carcinoma) and melanoma are summarized, for each PSM. (3) There are extensive reports on antihypertensives and statins relative to other PSMs, with positive and null findings, respectively. Fewer studies have explored amiodarone, metformin, antimicrobials and vemurafenib. No studies report on the individual skin cancer risks in glyburide, naproxen, piroxicam, chlorpromazine, thioridazine and nalidixic acid users. (4) The research gaps in understanding the relationship between PSMs and skin cancer outlined in this review should be prioritized because the US population is aging. Thus the number of patients prescribed PSMs is likely to continue to rise.

Keywords: basal cell carcinoma; melanoma; photosensitizing medication; squamous cell carcinoma

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