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Pachen M, Abukar Y, Shanks J, et al. Regulation of Coronary Blood Flow by the Carotid Body Chemoreceptors in Ovine Heart Failure. Front Physiol. 2021;12:681135doi: 10.3389/fphys.2021.681135.
Pachen, M., Abukar, Y., Shanks, J., Lever, N., & Ramchandra, R. (2021). Regulation of Coronary Blood Flow by the Carotid Body Chemoreceptors in Ovine Heart Failure. Frontiers in physiology, 12681135. https://doi.org/10.3389/fphys.2021.681135
Pachen, Mridula, et al. "Regulation of Coronary Blood Flow by the Carotid Body Chemoreceptors in Ovine Heart Failure." Frontiers in physiology vol. 12 (2021): 681135. doi: https://doi.org/10.3389/fphys.2021.681135
Pachen M, Abukar Y, Shanks J, Lever N, Ramchandra R. Regulation of Coronary Blood Flow by the Carotid Body Chemoreceptors in Ovine Heart Failure. Front Physiol. 2021 May 28;12:681135. doi: 10.3389/fphys.2021.681135. eCollection 2021. PMID: 34122147; PMCID: PMC8195281.
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Front Physiol. 2021 May 28;12:681135. doi: 10.3389/fphys.2021.681135. eCollection 2021.

Regulation of Coronary Blood Flow by the Carotid Body Chemoreceptors in Ovine Heart Failure.

Frontiers in physiology

Mridula Pachen, Yonis Abukar, Julia Shanks, Nigel Lever, Rohit Ramchandra

Affiliations

  1. Department of Physiology, University of Auckland, Auckland, New Zealand.
  2. Department of Medicine, University of Auckland and Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand.

PMID: 34122147 PMCID: PMC8195281 DOI: 10.3389/fphys.2021.681135

Abstract

Carotid bodies (CBs) are peripheral chemoreceptors, which are primary sensors of systemic hypoxia and their activation produces respiratory, autonomic, and cardiovascular adjustments critical for body homeostasis. We have previously shown that carotid chemoreceptor stimulation increases directly recorded cardiac sympathetic nerve activity (cardiac SNA) which increases coronary blood flow (CoBF) in conscious normal sheep. Previous studies have shown that chemoreflex sensitivity is augmented in heart failure (HF). We hypothesized that carotid chemoreceptor stimulation would increase CoBF to a greater extent in HF than control sheep. Experiments were conducted in conscious HF sheep and control sheep (

Copyright © 2021 Pachen, Abukar, Shanks, Lever and Ramchandra.

Keywords: cardiorespiratory; carotid body; chemoreflex activation; coronary blood flow; heart failure; sympathetic nerve activity

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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