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Fan X, Wu X, Crawford R, et al. Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development. Front Cell Dev Biol. 2021;9:659654doi: 10.3389/fcell.2021.659654.
Fan, X., Wu, X., Crawford, R., Xiao, Y., & Prasadam, I. (2021). Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development. Frontiers in cell and developmental biology, 9659654. https://doi.org/10.3389/fcell.2021.659654
Fan, Xiwei, et al. "Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development." Frontiers in cell and developmental biology vol. 9 (2021): 659654. doi: https://doi.org/10.3389/fcell.2021.659654
Fan X, Wu X, Crawford R, Xiao Y, Prasadam I. Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development. Front Cell Dev Biol. 2021 May 10;9:659654. doi: 10.3389/fcell.2021.659654. eCollection 2021. PMID: 34041240; PMCID: PMC8142862.
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Front Cell Dev Biol. 2021 May 10;9:659654. doi: 10.3389/fcell.2021.659654. eCollection 2021.

Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development.

Frontiers in cell and developmental biology

Xiwei Fan, Xiaoxin Wu, Ross Crawford, Yin Xiao, Indira Prasadam

Affiliations

  1. Faculty of Science and Engineering, School of Mechanical, Medical and Process Engineering, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
  2. Orthopaedic Department, The Prince Charles Hospital, Brisbane, QLD, Australia.
  3. Australia-China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, Brisbane, QLD, Australia.

PMID: 34041240 PMCID: PMC8142862 DOI: 10.3389/fcell.2021.659654

Abstract

Osteoarthritis (OA) is a long-term condition that causes joint pain and reduced movement. Notably, the same pathways governing cell growth, death, and differentiation during the growth and development of the body are also common drivers of OA. The osteochondral interface is a vital structure located between hyaline cartilage and subchondral bone. It plays a critical role in maintaining the physical and biological function, conveying joint mechanical stress, maintaining chondral microenvironment, as well as crosstalk and substance exchange through the osteochondral unit. In this review, we summarized the progress in research concerning the area of osteochondral junction, including its pathophysiological changes, molecular interactions, and signaling pathways that are related to the ultrastructure change. Multiple potential treatment options were also discussed in this review. A thorough understanding of these biological changes and molecular mechanisms in the pathologic process will advance our understanding of OA progression, and inform the development of effective therapeutics targeting OA.

Copyright © 2021 Fan, Wu, Crawford, Xiao and Prasadam.

Keywords: cartilage; endochondral; hypertrophy; interaction; osteoarthritis; osteochondral junction

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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