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Altincekic N, Korn SM, Qureshi NS, et al. Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications. Front Mol Biosci. 2021;8:653148doi: 10.3389/fmolb.2021.653148.
Altincekic, N., Korn, S. M., Qureshi, N. S., Dujardin, M., Ninot-Pedrosa, M., Abele, R., Abi Saad, M. J., Alfano, C., Almeida, F. C. L., Alshamleh, I., de Amorim, G. C., Anderson, T. K., Anobom, C. D., Anorma, C., Bains, J. K., Bax, A., Blackledge, M., Blechar, J., Böckmann, A., Brigandat, L., Bula, A., Bütikofer, M., Camacho-Zarco, A. R., Carlomagno, T., Caruso, I. P., Ceylan, B., Chaikuad, A., Chu, F., Cole, L., Crosby, M. G., de Jesus, V., Dhamotharan, K., Felli, I. C., Ferner, J., Fleischmann, Y., Fogeron, M. L., Fourkiotis, N. K., Fuks, C., Fürtig, B., Gallo, A., Gande, S. L., Gerez, J. A., Ghosh, D., Gomes-Neto, F., Gorbatyuk, O., Guseva, S., Hacker, C., Häfner, S., Hao, B., Hargittay, B., Henzler-Wildman, K., Hoch, J. C., Hohmann, K. F., Hutchison, M. T., Jaudzems, K., Jović, K., Kaderli, J., Kalniņš, G., Kaņepe, I., Kirchdoerfer, R. N., Kirkpatrick, J., Knapp, S., Krishnathas, R., Kutz, F., Zur Lage, S., Lambertz, R., Lang, A., Laurents, D., Lecoq, L., Linhard, V., Löhr, F., Malki, A., Bessa, L. M., Martin, R. W., Matzel, T., Maurin, D., McNutt, S. W., Mebus-Antunes, N. C., Meier, B. H., Meiser, N., Mompeán, M., Monaca, E., Montserret, R., Mariño Perez, L., Moser, C., Muhle-Goll, C., Neves-Martins, T. C., Ni, X., Norton-Baker, B., Pierattelli, R., Pontoriero, L., Pustovalova, Y., Ohlenschläger, O., Orts, J., Da Poian, A. T., Pyper, D. J., Richter, C., Riek, R., Rienstra, C. M., Robertson, A., Pinheiro, A. S., Sabbatella, R., Salvi, N., Saxena, K., Schulte, L., Schiavina, M., Schwalbe, H., Silber, M., Almeida, M. D. S., Sprague-Piercy, M. A., Spyroulias, G. A., Sreeramulu, S., Tants, J. N., Tārs, K., Torres, F., Töws, S., Treviño, M. �. �., Trucks, S., Tsika, A. C., Varga, K., Wang, Y., Weber, M. E., Weigand, J. E., Wiedemann, C., Wirmer-Bartoschek, J., Wirtz Martin, M. A., Zehnder, J., Hengesbach, M., & Schlundt, A. (2021). Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications. Frontiers in molecular biosciences, 8653148. https://doi.org/10.3389/fmolb.2021.653148
Altincekic, Nadide, et al. "Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications." Frontiers in molecular biosciences vol. 8 (2021): 653148. doi: https://doi.org/10.3389/fmolb.2021.653148
Altincekic N, Korn SM, Qureshi NS, Dujardin M, Ninot-Pedrosa M, Abele R, Abi Saad MJ, Alfano C, Almeida FCL, Alshamleh I, de Amorim GC, Anderson TK, Anobom CD, Anorma C, Bains JK, Bax A, Blackledge M, Blechar J, Böckmann A, Brigandat L, Bula A, Bütikofer M, Camacho-Zarco AR, Carlomagno T, Caruso IP, Ceylan B, Chaikuad A, Chu F, Cole L, Crosby MG, de Jesus V, Dhamotharan K, Felli IC, Ferner J, Fleischmann Y, Fogeron ML, Fourkiotis NK, Fuks C, Fürtig B, Gallo A, Gande SL, Gerez JA, Ghosh D, Gomes-Neto F, Gorbatyuk O, Guseva S, Hacker C, Häfner S, Hao B, Hargittay B, Henzler-Wildman K, Hoch JC, Hohmann KF, Hutchison MT, Jaudzems K, Jović K, Kaderli J, Kalniņš G, Kaņepe I, Kirchdoerfer RN, Kirkpatrick J, Knapp S, Krishnathas R, Kutz F, Zur Lage S, Lambertz R, Lang A, Laurents D, Lecoq L, Linhard V, Löhr F, Malki A, Bessa LM, Martin RW, Matzel T, Maurin D, McNutt SW, Mebus-Antunes NC, Meier BH, Meiser N, Mompeán M, Monaca E, Montserret R, Mariño Perez L, Moser C, Muhle-Goll C, Neves-Martins TC, Ni X, Norton-Baker B, Pierattelli R, Pontoriero L, Pustovalova Y, Ohlenschläger O, Orts J, Da Poian AT, Pyper DJ, Richter C, Riek R, Rienstra CM, Robertson A, Pinheiro AS, Sabbatella R, Salvi N, Saxena K, Schulte L, Schiavina M, Schwalbe H, Silber M, Almeida MDS, Sprague-Piercy MA, Spyroulias GA, Sreeramulu S, Tants JN, Tārs K, Torres F, Töws S, Treviño MÁ, Trucks S, Tsika AC, Varga K, Wang Y, Weber ME, Weigand JE, Wiedemann C, Wirmer-Bartoschek J, Wirtz Martin MA, Zehnder J, Hengesbach M, Schlundt A. Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications. Front Mol Biosci. 2021 May 10;8:653148. doi: 10.3389/fmolb.2021.653148. eCollection 2021. PMID: 34041264; PMCID: PMC8141814.
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Front Mol Biosci. 2021 May 10;8:653148. doi: 10.3389/fmolb.2021.653148. eCollection 2021.

Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications.

Frontiers in molecular biosciences

Nadide Altincekic, Sophie Marianne Korn, Nusrat Shahin Qureshi, Marie Dujardin, Martí Ninot-Pedrosa, Rupert Abele, Marie Jose Abi Saad, Caterina Alfano, Fabio C L Almeida, Islam Alshamleh, Gisele Cardoso de Amorim, Thomas K Anderson, Cristiane D Anobom, Chelsea Anorma, Jasleen Kaur Bains, Adriaan Bax, Martin Blackledge, Julius Blechar, Anja Böckmann, Louis Brigandat, Anna Bula, Matthias Bütikofer, Aldo R Camacho-Zarco, Teresa Carlomagno, Icaro Putinhon Caruso, Betül Ceylan, Apirat Chaikuad, Feixia Chu, Laura Cole, Marquise G Crosby, Vanessa de Jesus, Karthikeyan Dhamotharan, Isabella C Felli, Jan Ferner, Yanick Fleischmann, Marie-Laure Fogeron, Nikolaos K Fourkiotis, Christin Fuks, Boris Fürtig, Angelo Gallo, Santosh L Gande, Juan Atilio Gerez, Dhiman Ghosh, Francisco Gomes-Neto, Oksana Gorbatyuk, Serafima Guseva, Carolin Hacker, Sabine Häfner, Bing Hao, Bruno Hargittay, K Henzler-Wildman, Jeffrey C Hoch, Katharina F Hohmann, Marie T Hutchison, Kristaps Jaudzems, Katarina Jović, Janina Kaderli, Gints Kalniņš, Iveta Kaņepe, Robert N Kirchdoerfer, John Kirkpatrick, Stefan Knapp, Robin Krishnathas, Felicitas Kutz, Susanne Zur Lage, Roderick Lambertz, Andras Lang, Douglas Laurents, Lauriane Lecoq, Verena Linhard, Frank Löhr, Anas Malki, Luiza Mamigonian Bessa, Rachel W Martin, Tobias Matzel, Damien Maurin, Seth W McNutt, Nathane Cunha Mebus-Antunes, Beat H Meier, Nathalie Meiser, Miguel Mompeán, Elisa Monaca, Roland Montserret, Laura Mariño Perez, Celine Moser, Claudia Muhle-Goll, Thais Cristtina Neves-Martins, Xiamonin Ni, Brenna Norton-Baker, Roberta Pierattelli, Letizia Pontoriero, Yulia Pustovalova, Oliver Ohlenschläger, Julien Orts, Andrea T Da Poian, Dennis J Pyper, Christian Richter, Roland Riek, Chad M Rienstra, Angus Robertson, Anderson S Pinheiro, Raffaele Sabbatella, Nicola Salvi, Krishna Saxena, Linda Schulte, Marco Schiavina, Harald Schwalbe, Mara Silber, Marcius da Silva Almeida, Marc A Sprague-Piercy, Georgios A Spyroulias, Sridhar Sreeramulu, Jan-Niklas Tants, Kaspars Tārs, Felix Torres, Sabrina Töws, Miguel Á Treviño, Sven Trucks, Aikaterini C Tsika, Krisztina Varga, Ying Wang, Marco E Weber, Julia E Weigand, Christoph Wiedemann, Julia Wirmer-Bartoschek, Maria Alexandra Wirtz Martin, Johannes Zehnder, Martin Hengesbach, Andreas Schlundt

Affiliations

  1. Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, Frankfurt am Main, Germany.
  2. Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main, Germany.
  3. Institute for Molecular Biosciences, Goethe University Frankfurt, Frankfurt am Main, Germany.
  4. Molecular Microbiology and Structural Biochemistry, UMR 5086, CNRS/Lyon University, Lyon, France.
  5. Institute for Biochemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
  6. Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, ETH Zurich, Zurich, Switzerland.
  7. Structural Biology and Biophysics Unit, Fondazione Ri.MED, Palermo, Italy.
  8. National Center of Nuclear Magnetic Resonance (CNRMN, CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  9. Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  10. Multidisciplinary Center for Research in Biology (NUMPEX), Campus Duque de Caxias Federal University of Rio de Janeiro, Duque de Caxias, Brazil.
  11. Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI, United States.
  12. Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  13. Department of Chemistry, University of California, Irvine, CA, United States.
  14. LCP, NIDDK, NIH, Bethesda, MD, United States.
  15. Univ. Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.
  16. Latvian Institute of Organic Synthesis, Riga, Latvia.
  17. BMWZ and Institute of Organic Chemistry, Leibniz University Hannover, Hannover, Germany.
  18. Group of NMR-Based Structural Chemistry, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  19. Multiuser Center for Biomolecular Innovation (CMIB), Department of Physics, São Paulo State University (UNESP), São José do Rio Preto, Brazil.
  20. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
  21. Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany.
  22. Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH, United States.
  23. Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, United States.
  24. Magnetic Resonance Centre (CERM), University of Florence, Sesto Fiorentino, Italy.
  25. Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, Italy.
  26. Department of Pharmacy, University of Patras, Patras, Greece.
  27. Laboratory of Toxinology, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
  28. Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT, United States.
  29. Signals GmbH & Co. KG, Frankfurt am Main, Germany.
  30. Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena, Germany.
  31. Latvian Biomedical Research and Study Centre, Riga, Latvia.
  32. "Rocasolano" Institute for Physical Chemistry (IQFR), Spanish National Research Council (CSIC), Madrid, Spain.
  33. Institute of Biophysical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
  34. IBG-4, Karlsruhe Institute of Technology, Karlsruhe, Germany.
  35. Department of Biochemistry and National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI, United States.
  36. Department of Biology, Technical University of Darmstadt, Darmstadt, Germany.
  37. Institute of Biochemistry and Biotechnology, Charles Tanford Protein Centre, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany.

PMID: 34041264 PMCID: PMC8141814 DOI: 10.3389/fmolb.2021.653148

Abstract

The highly infectious disease COVID-19 caused by the

Copyright © 2021 Altincekic, Korn, Qureshi, Dujardin, Ninot-Pedrosa, Abele, Abi Saad, Alfano, Almeida, Alshamleh, de Amorim, Anderson, Anobom, Anorma, Bains, Bax, Blackledge, Blechar, Böckmann, Brigandat, Bula, Bütikofer, Camacho-Zarco, Carlomagno, Caruso, Ceylan, Chaikuad, Chu, Cole, Crosby, de Jesus, Dhamotharan, Felli, Ferner, Fleischmann, Fogeron, Fourkiotis, Fuks, Fürtig, Gallo, Gande, Gerez, Ghosh, Gomes-Neto, Gorbatyuk, Guseva, Hacker, Häfner, Hao, Hargittay, Henzler-Wildman, Hoch, Hohmann, Hutchison, Jaudzems, Jović, Kaderli, Kalniņš, Kaņepe, Kirchdoerfer, Kirkpatrick, Knapp, Krishnathas, Kutz, zur Lage, Lambertz, Lang, Laurents, Lecoq, Linhard, Löhr, Malki, Bessa, Martin, Matzel, Maurin, McNutt, Mebus-Antunes, Meier, Meiser, Mompeán, Monaca, Montserret, Mariño Perez, Moser, Muhle-Goll, Neves-Martins, Ni, Norton-Baker, Pierattelli, Pontoriero, Pustovalova, Ohlenschläger, Orts, Da Poian, Pyper, Richter, Riek, Rienstra, Robertson, Pinheiro, Sabbatella, Salvi, Saxena, Schulte, Schiavina, Schwalbe, Silber, Almeida, Sprague-Piercy, Spyroulias, Sreeramulu, Tants, Tārs, Torres, Töws, Treviño, Trucks, Tsika, Varga, Wang, Weber, Weigand, Wiedemann, Wirmer-Bartoschek, Wirtz Martin, Zehnder, Hengesbach and Schlundt.

Keywords: COVID-19; NMR spectroscopy; SARS-CoV-2; accessory proteins; cell-free protein synthesis; intrinsically disordered region; nonstructural proteins; structural proteins

Conflict of interest statement

CH was employed by Signals GmbH & Co. KG. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potenti

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