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St Denis JD, Hall RJ, Murray CW, et al. Fragment-based drug discovery: opportunities for organic synthesis. RSC Med Chem. 2020;12(3):321-329doi: 10.1039/d0md00375a.
St Denis, J. D., Hall, R. J., Murray, C. W., Heightman, T. D., & Rees, D. C. (2020). Fragment-based drug discovery: opportunities for organic synthesis. RSC medicinal chemistry, 12(3), 321-329. https://doi.org/10.1039/d0md00375a
St Denis, Jeffrey D, et al. "Fragment-based drug discovery: opportunities for organic synthesis." RSC medicinal chemistry vol. 12,3 (2020): 321-329. doi: https://doi.org/10.1039/d0md00375a
St Denis JD, Hall RJ, Murray CW, Heightman TD, Rees DC. Fragment-based drug discovery: opportunities for organic synthesis. RSC Med Chem. 2020 Dec 24;12(3):321-329. doi: 10.1039/d0md00375a. PMID: 34041484; PMCID: PMC8130625.
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RSC Med Chem. 2020 Dec 24;12(3):321-329. doi: 10.1039/d0md00375a.

Fragment-based drug discovery: opportunities for organic synthesis.

RSC medicinal chemistry

Jeffrey D St Denis, Richard J Hall, Christopher W Murray, Tom D Heightman, David C Rees

Affiliations

  1. Astex Pharmaceuticals 436 Cambridge Science Park Cambridge CB4 0QA UK [email protected] [email protected].

PMID: 34041484 PMCID: PMC8130625 DOI: 10.1039/d0md00375a

Abstract

This Review describes the increasing demand for organic synthesis to facilitate fragment-based drug discovery (FBDD), focusing on polar, unprotected fragments. In FBDD, X-ray crystal structures are used to design target molecules for synthesis with new groups added onto a fragment

This journal is © The Royal Society of Chemistry.

Conflict of interest statement

The authors are employees of Astex Pharmaceuticals.

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