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Melo N, Policarpo S, Dias M, et al. Pantoprazole: An Unusual Suspect in a Patient with Fever. Eur J Case Rep Intern Med. 2021;8(5):002571doi: 10.12890/2021_002571.
Melo, N., Policarpo, S., Dias, M., & Almeida, J. (2021). Pantoprazole: An Unusual Suspect in a Patient with Fever. European journal of case reports in internal medicine, 8(5), 002571. https://doi.org/10.12890/2021_002571
Melo, Nuno, et al. "Pantoprazole: An Unusual Suspect in a Patient with Fever." European journal of case reports in internal medicine vol. 8,5 (2021): 002571. doi: https://doi.org/10.12890/2021_002571
Melo N, Policarpo S, Dias M, Almeida J. Pantoprazole: An Unusual Suspect in a Patient with Fever. Eur J Case Rep Intern Med. 2021 May 28;8(5):002571. doi: 10.12890/2021_002571. eCollection 2021. PMID: 34123946; PMCID: PMC8191360.
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Eur J Case Rep Intern Med. 2021 May 28;8(5):002571. doi: 10.12890/2021_002571. eCollection 2021.

Pantoprazole: An Unusual Suspect in a Patient with Fever.

European journal of case reports in internal medicine

Nuno Melo, Sílvia Policarpo, Manuela Dias, Jorge Almeida

Affiliations

  1. Internal Medicine Department, Centro Hospitalar e Universitário de São João, Porto, Portugal.
  2. Infectious Disease Department, Centro Hospitalar e Universitário de São João, Porto, Portugal.

PMID: 34123946 PMCID: PMC8191360 DOI: 10.12890/2021_002571

Abstract

Drugs can cause fever of unknown origin. Drug fever is a diagnosis of exclusion and can lead to unnecessary investigations and prolonged hospitalization. Any drug can be responsible. Here, we describe the case of a woman admitted because of acute hepatitis. Pantoprazole was started for stress ulcer prophylaxis when she was admitted to the ICU. Fever developed a few days later and an extensive diagnostic work-up was negative. Fever remitted after pantoprazole discontinuation and the diagnosis of drug fever was established.

LEARNING POINTS: Despite extensive diagnostic work-up, the aetiology of acute liver failure remains unclear in a large proportion of cases.Drug fever is a diagnosis of exclusion and must be considered in every patient with unexplained fever; any drug should be seen as a possible offending agent.Pantoprazole, a commonly prescribed drug, can be a rare cause of fever.

© EFIM 2021.

Keywords: Drug fever; acute hepatitis; pantoprazole

Conflict of interest statement

Conflicts of Interests: The authors disclose no conflicts of interest.

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