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Mørup N, Stakaitis R, Golubickaite I, et al. Small RNAs in Seminal Plasma as Novel Biomarkers for Germ Cell Tumors. Cancers (Basel). 2021;13(10)doi: 10.3390/cancers13102346.
Mørup, N., Stakaitis, R., Golubickaite, I., Riera, M., Dalgaard, M. D., Schierup, M. H., Jørgensen, N., Daugaard, G., Juul, A., & Almstrup, K. (2021). Small RNAs in Seminal Plasma as Novel Biomarkers for Germ Cell Tumors. Cancers, 13(10), . https://doi.org/10.3390/cancers13102346
Mørup, Nina, et al. "Small RNAs in Seminal Plasma as Novel Biomarkers for Germ Cell Tumors." Cancers vol. 13,10 (2021). doi: https://doi.org/10.3390/cancers13102346
Mørup N, Stakaitis R, Golubickaite I, Riera M, Dalgaard MD, Schierup MH, Jørgensen N, Daugaard G, Juul A, Almstrup K. Small RNAs in Seminal Plasma as Novel Biomarkers for Germ Cell Tumors. Cancers (Basel). 2021 May 13;13(10). doi: 10.3390/cancers13102346. PMID: 34067956; PMCID: PMC8152278.
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Cancers (Basel). 2021 May 13;13(10). doi: 10.3390/cancers13102346.

Small RNAs in Seminal Plasma as Novel Biomarkers for Germ Cell Tumors.

Cancers

Nina Mørup, Rytis Stakaitis, Ieva Golubickaite, Meritxell Riera, Marlene Danner Dalgaard, Mikkel H Schierup, Niels Jørgensen, Gedske Daugaard, Anders Juul, Kristian Almstrup

Affiliations

  1. Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  2. International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital, 2100 Copenhagen, Denmark.
  3. Laboratory of Molecular Neurooncology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
  4. Department of Genetics and Molecular Medicine, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.
  5. Bioinformatics Research Centre, Aarhus University, 8000 Aarhus C, Denmark.
  6. DTU Multi-Assay Core, Department of Health Technology, Technical University of Denmark, 2800 Lyngby, Denmark.
  7. Department of Oncology, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
  8. Department of Clinical Medicine, University of Copenhagen, 2100 Copenhagen, Denmark.

PMID: 34067956 PMCID: PMC8152278 DOI: 10.3390/cancers13102346

Abstract

Circulating miRNAs secreted by testicular germ cell tumors (TGCT) show great potential as novel non-invasive biomarkers for diagnosis of TGCT. Seminal plasma (SP) represents a biofluid closer to the primary site. Here, we investigate whether small RNAs in SP can be used to diagnose men with TGCTs or the precursor lesions, germ cell neoplasia in situ (GCNIS). Small RNAs isolated from SP from men with TGCTs (

Keywords: diagnostics; small RNAs; testicular cancer

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