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Bernardos A, Božik M, Montero A, et al. Secreted Enzyme-Responsive System for Controlled Antifungal Agent Release. Nanomaterials (Basel). 2021;11(5)doi: 10.3390/nano11051280.
Bernardos, A., Božik, M., Montero, A., Pérez-Esteve, �. �., García-Casado, E., Lhotka, M., Fraňková, A., Marcos, M. D., Barat, J. M., Martínez-Máñez, R., & Klouček, P. (2021). Secreted Enzyme-Responsive System for Controlled Antifungal Agent Release. Nanomaterials (Basel, Switzerland), 11(5), . https://doi.org/10.3390/nano11051280
Bernardos, Andrea, et al. "Secreted Enzyme-Responsive System for Controlled Antifungal Agent Release." Nanomaterials (Basel, Switzerland) vol. 11,5 (2021). doi: https://doi.org/10.3390/nano11051280
Bernardos A, Božik M, Montero A, Pérez-Esteve É, García-Casado E, Lhotka M, Fraňková A, Marcos MD, Barat JM, Martínez-Máñez R, Klouček P. Secreted Enzyme-Responsive System for Controlled Antifungal Agent Release. Nanomaterials (Basel). 2021 May 13;11(5). doi: 10.3390/nano11051280. PMID: 34068155; PMCID: PMC8153022.
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Nanomaterials (Basel). 2021 May 13;11(5). doi: 10.3390/nano11051280.

Secreted Enzyme-Responsive System for Controlled Antifungal Agent Release.

Nanomaterials (Basel, Switzerland)

Andrea Bernardos, Matěj Božik, Ana Montero, Édgar Pérez-Esteve, Esther García-Casado, Miloslav Lhotka, Adéla Fraňková, María Dolores Marcos, José Manuel Barat, Ramón Martínez-Máñez, Pavel Klouček

Affiliations

  1. Department of Food Science, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 16500 Praha-Suchdol, Czech Republic.
  2. Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Camino de Vera s/n, 46022 Valencia, Spain.
  3. CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Av. Monforte de Lemos 3-5, Pabellón 11, Planta 0, 28029 Madrid, Spain.
  4. Department of Food Technology, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
  5. Department of Inorganic Technology, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, Praha 6, 16628 Prague, Czech Republic.

PMID: 34068155 PMCID: PMC8153022 DOI: 10.3390/nano11051280

Abstract

Essential oil components (EOCs) such as eugenol play a significant role in plant antimicrobial defense. Due to the volatility and general reactivity of these molecules, plants have evolved smart systems for their storage and release, which are key prerequisites for their efficient use. In this study, biomimetic systems for the controlled release of eugenol, inspired by natural plant defense mechanisms, were prepared and their antifungal activity is described. Delivery and antifungal studies of mesoporous silica nanoparticles (MSN) loaded with eugenol and capped with different saccharide gates-starch, maltodextrin, maltose and glucose-against fungus

Keywords: Aspergillus niger; antifungal; antimicrobial; essential oil component; exogenous enzyme; nanoparticles

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