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Morrow R, Funk R, Becker M, et al. Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease. Pharmaceuticals (Basel). 2021;14(5)doi: 10.3390/ph14050463.
Morrow, R., Funk, R., Becker, M., Sherman, A., Van Haandel, L., Hudson, T., Casini, R., & Shakhnovich, V. (2021). Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease. Pharmaceuticals (Basel, Switzerland), 14(5), . https://doi.org/10.3390/ph14050463
Morrow, Ryan, et al. "Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease." Pharmaceuticals (Basel, Switzerland) vol. 14,5 (2021). doi: https://doi.org/10.3390/ph14050463
Morrow R, Funk R, Becker M, Sherman A, Van Haandel L, Hudson T, Casini R, Shakhnovich V. Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease. Pharmaceuticals (Basel). 2021 May 14;14(5). doi: 10.3390/ph14050463. PMID: 34069031; PMCID: PMC8156207.
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Pharmaceuticals (Basel). 2021 May 14;14(5). doi: 10.3390/ph14050463.

Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease.

Pharmaceuticals (Basel, Switzerland)

Ryan Morrow, Ryan Funk, Mara Becker, Ashley Sherman, Leon Van Haandel, Taina Hudson, Rebecca Casini, Valentina Shakhnovich

Affiliations

  1. Children's Mercy Kansas City, Kansas City, MO 64108, USA.
  2. University of Missouri Kansas City School of Medicine, Kansas City, MO 64108, USA.
  3. Department of Pharmacy Practice, University of Kansas, Kansas City, KS 60047, USA.
  4. Department of Pediatrics, Duke University Hospital, Durham, NC 27705, USA.
  5. Abbvie Pharmaceuticals, North Chicago, IL 60085, USA.
  6. NorthShore University Health System, Skokie, IL 60201, USA.

PMID: 34069031 PMCID: PMC8156207 DOI: 10.3390/ph14050463

Abstract

Inside cells, the immunomodulator methotrexate (MTX) undergoes the addition of glutamates to form methotrexate polyglutamates (MTX-Glu)-promising biomarkers of systemic exposure and treatment response to MTX in rheumatology. MTX-Glu are underexplored in Inflammatory Bowel Disease (IBD), with no data in pediatrics. In this cross-sectional secondary analysis, we assessed the relationships between MTX-Glu and MTX dose and treatment response in pediatric IBD. Twenty-one children with IBD, receiving maintenance therapy with infliximab (IFX) and MTX, had MTX-Glu

Keywords: Crohn’s disease; inflammatory bowel disease; infliximab; methotrexate; methotrexate polyglutamates; pediatric; ulcerative colitis

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