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Sanders EC, Burkes RM, Mock JR, et al. Bronchoalveolar Lavage and Plasma Cathelicidin Response to 25-Hydroxy Vitamin D Supplementation: A Pilot Study. Chronic Obstr Pulm Dis. 2021;8(3):371-381doi: 10.15326/jcopdf.2021.0220.
Sanders, E. C., Burkes, R. M., Mock, J. R., Brown, T. T., Wise, R. A., Hansel, N. N., Liu, M. C., & Drummond, M. B. (2021). Bronchoalveolar Lavage and Plasma Cathelicidin Response to 25-Hydroxy Vitamin D Supplementation: A Pilot Study. Chronic obstructive pulmonary diseases (Miami, Fla.), 8(3), 371-381. https://doi.org/10.15326/jcopdf.2021.0220
Sanders, Emily C, et al. "Bronchoalveolar Lavage and Plasma Cathelicidin Response to 25-Hydroxy Vitamin D Supplementation: A Pilot Study." Chronic obstructive pulmonary diseases (Miami, Fla.) vol. 8,3 (2021): 371-381. doi: https://doi.org/10.15326/jcopdf.2021.0220
Sanders EC, Burkes RM, Mock JR, Brown TT, Wise RA, Hansel NN, Liu MC, Drummond MB. Bronchoalveolar Lavage and Plasma Cathelicidin Response to 25-Hydroxy Vitamin D Supplementation: A Pilot Study. Chronic Obstr Pulm Dis. 2021 Jul 28;8(3):371-381. doi: 10.15326/jcopdf.2021.0220. PMID: 34044475; PMCID: PMC8428594.
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Chronic Obstr Pulm Dis. 2021 Jul 28;8(3):371-381. doi: 10.15326/jcopdf.2021.0220.

Bronchoalveolar Lavage and Plasma Cathelicidin Response to 25-Hydroxy Vitamin D Supplementation: A Pilot Study.

Chronic obstructive pulmonary diseases (Miami, Fla.)

Emily C Sanders, Robert M Burkes, Jason R Mock, Todd T Brown, Robert A Wise, Nadia N Hansel, Mark C Liu, M Bradley Drummond

Affiliations

  1. Department of Internal Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
  2. Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati, Cincinnati, Ohio, United States.
  3. Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
  4. Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University, Baltimore, Maryland, United States.
  5. Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.

PMID: 34044475 PMCID: PMC8428594 DOI: 10.15326/jcopdf.2021.0220

Abstract

INTRODUCTION: Cathelicidin is a vitamin D-regulated, antimicrobial peptide involved in the innate immune response of the airways. Reduced plasma cathelicidin concentrations are independently associated with worse pulmonary outcomes in current and former smokers. This study aimed to determine whether oral vitamin D supplementation in vitamin D-deficient current smokers increases plasma and bronchoalveolar lavage (BAL) cathelicidin levels.

METHODS: Vitamin D-deficient (25-hydroxy vitamin D [25-OH vitamin D] <20 ng/ml) smokers (n=17) underwent collection of plasma and BAL for cathelicidin and 25-OH vitamin D measurements before and after 8 weeks of oral supplementation with 50,000 IU vitamin D3 weekly. Differences between baseline and 8-week levels of cathelicidin and 25-OH vitamin D in blood and BAL were assessed along with correlations between serum 25-OH vitamin D, plasma cathelicidin, and BAL cathelicidin.

RESULTS: At baseline, there was no correlation between BAL and plasma cathelicidin. There was a significant increase in 25-OH vitamin D (median 17.0 to 43.3 ng/mL,

CONCLUSIONS: Oral vitamin D supplementation, while increasing serum 25-OH vitamin D levels, does not increase plasma or BAL cathelicidin levels in vitamin D-deficient, active smokers. The lack of increased BAL cathelicidin may be explained by multiple factors related to dosing, smoking effects, or putative mechanisms of engagement. Future studies are needed to determine the effects of vitamin D supplementation on lung and blood functional activity.

JCOPDF © 2021.

Keywords: antimicrobial cationic peptides; biomarkers; vitamin D

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