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He L, Guo W, Qiu J, et al. Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level. Front Endocrinol (Lausanne). 2021;12:652512doi: 10.3389/fendo.2021.652512.
He, L., Guo, W., Qiu, J., An, X., & Lu, W. (2021). Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level. Frontiers in endocrinology, 12652512. https://doi.org/10.3389/fendo.2021.652512
He, Lemin, et al. "Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level." Frontiers in endocrinology vol. 12 (2021): 652512. doi: https://doi.org/10.3389/fendo.2021.652512
He L, Guo W, Qiu J, An X, Lu W. Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level. Front Endocrinol (Lausanne). 2021 May 11;12:652512. doi: 10.3389/fendo.2021.652512. eCollection 2021. PMID: 34046011; PMCID: PMC8146460.
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Front Endocrinol (Lausanne). 2021 May 11;12:652512. doi: 10.3389/fendo.2021.652512. eCollection 2021.

Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level.

Frontiers in endocrinology

Lemin He, Wei Guo, Jianfeng Qiu, Xingwei An, Weizhao Lu

Affiliations

  1. Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, China.
  2. Department of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China.
  3. Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
  4. Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Taian, China.
  5. Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.

PMID: 34046011 PMCID: PMC8146460 DOI: 10.3389/fendo.2021.652512

Abstract

OBJECTIVE: Serum hormone deficiencies during menopause transition may affect spontaneous brain activity and global cognition. The purpose of this study was to explore the differences in spontaneous brain activity between premenopausal and perimenopausal women, and to investigate the associations between spontaneous brain activity, serum hormone levels and global cognition.

METHODS: Thirty-two premenopausal women (47.75 ± 1.55 years) and twenty-five perimenopausal women (51.60 ± 1.63 years) underwent resting-state functional MRI (fMRI) scan. Clinical information including Mini-Mental State Examination (MMSE), levels of estradiol (E2), free testosterone, progesterone, prolactin, follicle-stimulating hormone and luteinizing hormone were measured. Regional homogeneity (ReHo) was used to evaluate spontaneous brain activity alterations between perimenopausal and premenopausal women. Correlation analysis was used to investigate the associations between brain functional alterations and clinical measures in perimenopausal group.

RESULTS: The results demonstrated increased ReHo value in the right lingual gyrus (LG) and decreased ReHo value in the right superior frontal gyrus (SFG) in perimenopausal women compared with premenopausal women. In perimenopausal group, ReHo of the right LG showed a negative correlation with level of E2 (r = -0.586, p = 0.002), ReHo of the right SFG showed a positive correlation with level of E2 (r = 0.470, p = 0.018) and MMSE (r = 0.614, p = 0.001).

CONCLUSIONS: The results demonstrated that women approaching menopause suffered from altered functions in brain regions related to cognitive function, working memory, the results also revealed a direct association between levels of E2 and brain functions in perimenopausal women.

Copyright © 2021 He, Guo, Qiu, An and Lu.

Keywords: ReHo; estradiol; functional magnetic resonance imaging; menopause; spontaneous brain activity

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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