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Huet F, Dupuy AM, Duflos C, et al. Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry. Future Sci OA. 2021;7(5):FSO697doi: 10.2144/fsoa-2020-0197.
Huet, F., Dupuy, A. M., Duflos, C., Reis, C. A., Kuster, N., Aguilhon, S., Cristol, J. P., & Roubille, F. (2021). Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry. Future science OA, 7(5), FSO697. https://doi.org/10.2144/fsoa-2020-0197
Huet, Fabien, et al. "Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry." Future science OA vol. 7,5 (2021): FSO697. doi: https://doi.org/10.2144/fsoa-2020-0197
Huet F, Dupuy AM, Duflos C, Reis CA, Kuster N, Aguilhon S, Cristol JP, Roubille F. Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry. Future Sci OA. 2021 Mar 29;7(5):FSO697. doi: 10.2144/fsoa-2020-0197. PMID: 34046195; PMCID: PMC8147742.
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Future Sci OA. 2021 Mar 29;7(5):FSO697. doi: 10.2144/fsoa-2020-0197.

Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry.

Future science OA

Fabien Huet, Anne-Marie Dupuy, Claire Duflos, Cintia Azara Reis, Nils Kuster, Sylvain Aguilhon, Jean-Paul Cristol, François Roubille

Affiliations

  1. Cardiology Department, University Hospital of Montpellier, Montpellier, France.
  2. PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR, 9214, Montpellier, 34090, France.
  3. Department of Biochemistry, Centre Ressources Biologiques de Montpellier, University Hospital of Montpellier, Montpellier, 34090, France.
  4. Medico-Economic Research Unit, CHU Montpellier, University of Montpellier, Montpellier, 34090, France.

PMID: 34046195 PMCID: PMC8147742 DOI: 10.2144/fsoa-2020-0197

Abstract

BACKGROUND: Whether soluble urokinase-type plasminogen activator receptor (suPAR) could be a valuable prognostic indicator remains uncertain.

MATERIALS & METHODS: Patients from STADE-HF (Soluble Suppression of Tumorigenesis-2 as a Help for Management of Diagnosis, Evaluation and Management of Heart Failure) were included for analysis.

RESULTS: 95 patients were included. The suPAR level of expression was significantly higher in the group of patients who died at one month (7.90 ± 4.35 ng/ml vs 11.94 ± 6.86 ng/ml; p < 0.05) or 1 year (7.28 ± 4.27 ng/ml vs 11.81 ± 4.88 ng/ml; p < 0.01), but there was no significant difference according to the readmission.

CONCLUSION: High suPAR levels during hospitalization for acute heart failure were highly predictive for the risk of mortality, but not the risk of readmission.

© 2021 Fabien Huet.

Keywords: acute heart failure; biomarkers; prognosis; suPAR

Conflict of interest statement

Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with th

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