Display options
Cite
Lee DY, Baron J, Wright CM, et al. Radiation Therapy for Chemotherapy Refractory Gingival Myeloid Sarcoma. Front Oncol. 2021;11:671514doi: 10.3389/fonc.2021.671514.
Lee, D. Y., Baron, J., Wright, C. M., Plastaras, J. P., Perl, A. E., & Paydar, I. (2021). Radiation Therapy for Chemotherapy Refractory Gingival Myeloid Sarcoma. Frontiers in oncology, 11671514. https://doi.org/10.3389/fonc.2021.671514
Lee, Daniel Y, et al. "Radiation Therapy for Chemotherapy Refractory Gingival Myeloid Sarcoma." Frontiers in oncology vol. 11 (2021): 671514. doi: https://doi.org/10.3389/fonc.2021.671514
Lee DY, Baron J, Wright CM, Plastaras JP, Perl AE, Paydar I. Radiation Therapy for Chemotherapy Refractory Gingival Myeloid Sarcoma. Front Oncol. 2021 May 10;11:671514. doi: 10.3389/fonc.2021.671514. eCollection 2021. PMID: 34046361; PMCID: PMC8143974.
Copy Download .nbib Format: NLM
Share it on

Front Oncol. 2021 May 10;11:671514. doi: 10.3389/fonc.2021.671514. eCollection 2021.

Radiation Therapy for Chemotherapy Refractory Gingival Myeloid Sarcoma.

Frontiers in oncology

Daniel Y Lee, Jonathan Baron, Christopher M Wright, John P Plastaras, Alexander E Perl, Ima Paydar

Affiliations

  1. University of Pennsylvania School of Medicine, Philadelphia, PA, United States.
  2. Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, United States.
  3. Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA, United States.

PMID: 34046361 PMCID: PMC8143974 DOI: 10.3389/fonc.2021.671514

Abstract

Gingival myeloid sarcoma (MS) refractory to induction chemotherapy is a rare clinical entity and can be treated with palliative radiation therapy (RT). However, there are few previously published reports of RT approaches for the treatment of gingival MS. We present a single institution retrospective observational study of adult patients treated with palliative RT for chemotherapy refractory gingival MS. A total of six patients diagnosed with gingival MS in the setting of relapsed or refractory acute myeloid leukemia treated with palliative RT were identified, with a median age of 66 (range 52-77). Patients were treated with radiation doses ranging from 5 to 20 Gy in 2-10 fractions. Two patients had adequate follow-up time to assess treatment response. One patient who was simulated with PET/CT experienced a local complete response, while the other patient required retreatment 2 months after initial treatment and experienced an eventual local partial response. Three patients experienced radiation mucositis, with one patient experiencing grade 5 toxicity attributed to concomitant treatment with the radiosensitizer hydroxyurea. We believe that this study can provide a practical reference point for other clinicians given the rarity of gingival MS requiring palliative radiation therapy as a clinical entity.

Copyright © 2021 Lee, Baron, Wright, Plastaras, Perl and Paydar.

Keywords: acute myeloid leukemia; chloroma; gingival; myeloid sarcoma; radiation

Conflict of interest statement

AP has been a consultant for and received research funding from Astellas Pharma outside this study. The remaining authors declare that the research was conducted in the absence of any commercial or fi

References

  1. Haematologica. 2010 Jun;95(6):860-3 - PubMed
  2. J Oral Maxillofac Pathol. 2016 Sep-Dec;20(3):523-526 - PubMed
  3. J Oral Maxillofac Pathol. 2018 Jan;22(Suppl 1):S77-S81 - PubMed
  4. Haematologica. 2011 Oct;96(10):1552-6 - PubMed
  5. J Clin Oncol. 2014 Sep 20;32(27):3059-68 - PubMed
  6. Clin Lymphoma Myeloma Leuk. 2017 May;17(5):263-267 - PubMed
  7. J Clin Oncol. 2003 Dec 15;21(24):4642-9 - PubMed
  8. Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1816-22 - PubMed
  9. AJR Am J Roentgenol. 2012 May;198(5):1175-9 - PubMed
  10. Biol Blood Marrow Transplant. 2012 Dec;18(12):1800-7 - PubMed
  11. Oral Surg Oral Med Oral Pathol. 1983 Jun;55(6):572-9 - PubMed
  12. Int J Radiat Oncol Biol Phys. 2018 Oct 1;102(2):314-319 - PubMed
  13. Arch Pathol Lab Med. 2013 Nov;137(11):1560-8 - PubMed
  14. Br J Radiol. 2017 Jul;90(1075):20160710 - PubMed
  15. Curr Oncol Rep. 2020 Jun 24;22(7):75 - PubMed

Publication Types