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Raducka A, Czylkowska A, Gobis K, et al. Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer. Materials (Basel). 2021;14(11)doi: 10.3390/ma14112958.
Raducka, A., Czylkowska, A., Gobis, K., Czarnecka, K., Szymański, P., & Świątkowski, M. (2021). Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer. Materials (Basel, Switzerland), 14(11), . https://doi.org/10.3390/ma14112958
Raducka, Anita, et al. "Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer." Materials (Basel, Switzerland) vol. 14,11 (2021). doi: https://doi.org/10.3390/ma14112958
Raducka A, Czylkowska A, Gobis K, Czarnecka K, Szymański P, Świątkowski M. Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer. Materials (Basel). 2021 May 30;14(11). doi: 10.3390/ma14112958. PMID: 34070886; PMCID: PMC8198142.
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Materials (Basel). 2021 May 30;14(11). doi: 10.3390/ma14112958.

Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer.

Materials (Basel, Switzerland)

Anita Raducka, Agnieszka Czylkowska, Katarzyna Gobis, Kamila Czarnecka, Paweł Szymański, Marcin Świątkowski

Affiliations

  1. Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
  2. Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gen. Hallera 107, 80-416 Gdansk, Poland.
  3. Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
  4. Department of Radiobiology and Radiation Protection, Military Institute of Hygiene and Epidemiology, 4 Kozielska St., 01-163 Warsaw, Poland.

PMID: 34070886 PMCID: PMC8198142 DOI: 10.3390/ma14112958

Abstract

Four new ligands and four new copper (II) coordination compounds were prepared and characterized by chemical, elemental analysis, cytotoxicity, and FTIR spectroscopy (Fourier transform infrared spectroscopy). The nature of metal-ligand coordination was investigated. The thermal properties of complexes in the solid state were studied using TG-MS techniques (thermogravimetric analysis coupled with mass spectrometry) under dynamic flowing air atmosphere to analyze the principal volatile thermal decomposition and fragmentation products that evolved during thermolysis. The intermediate and final solid thermolysis products were also determined. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate active metabolic cells as an IC

Keywords: benzimidazole derivatives; copper (II) coordination compounds; lung cancer; thermogravimetric analysis

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