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Murphy C, Upshaw NC, Thomas AS, et al. Impact of executive functioning on health-related quality of life of pediatric brain tumor survivors. Pediatr Blood Cancer. 2021;68(8):e29130doi: 10.1002/pbc.29130.
Murphy, C., Upshaw, N. C., Thomas, A. S., Fong, G., Janss, A., Mazewski, C., & Ingerski, L. M. (2021). Impact of executive functioning on health-related quality of life of pediatric brain tumor survivors. Pediatric blood & cancer, 68(8), e29130. https://doi.org/10.1002/pbc.29130
Murphy, Camara, et al. "Impact of executive functioning on health-related quality of life of pediatric brain tumor survivors." Pediatric blood & cancer vol. 68,8 (2021): e29130. doi: https://doi.org/10.1002/pbc.29130
Murphy C, Upshaw NC, Thomas AS, Fong G, Janss A, Mazewski C, Ingerski LM. Impact of executive functioning on health-related quality of life of pediatric brain tumor survivors. Pediatr Blood Cancer. 2021 Aug;68(8):e29130. doi: 10.1002/pbc.29130. Epub 2021 May 27. PMID: 34047487.
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Pediatr Blood Cancer. 2021 Aug;68(8):e29130. doi: 10.1002/pbc.29130. Epub 2021 May 27.

Impact of executive functioning on health-related quality of life of pediatric brain tumor survivors.

Pediatric blood & cancer

Camara Murphy, Naadira C Upshaw, Amanda S Thomas, Grace Fong, Anna Janss, Claire Mazewski, Lisa M Ingerski

Affiliations

  1. Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  2. Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

PMID: 34047487 DOI: 10.1002/pbc.29130

Abstract

BACKGROUND: Brain tumor survivors are at risk for significant late effects following treatment completion that may adversely impact health-related quality of life (HRQOL). The current study examines the relationship between executive functioning (EF) and HRQOL in pediatric brain tumor survivors within a longitudinal framework. We hypothesized that early deficits in EF would be related to less optimal HRQOL in this population.

PROCEDURE: The current study utilized retrospective medical chart review to identify neurocognitive correlates of HRQOL in 137 youth previously treated for a pediatric brain tumor. Participants completed the Pediatric Quality of Life Inventory (PedsQL) and neuropsychological assessment, including a well-validated measure of executive functioning (Behavior Rating Inventory of Executive Function; BRIEF). General linear regression and multivariate models were utilized to examine the relationship between child executive functioning and HRQOL.

RESULTS: Multiple domains of child executive functioning, as reported by parents on the BRIEF, significantly predicted parent-proxy reported HRQOL after controlling for demographic and medical covariates, including child intellectual functioning (IF). Similarly, after controlling for covariates, the BRIEF Cognitive Regulation Index was a significant predictor of self-reported physical and school functioning domains of HRQOL.

CONCLUSION: Current data demonstrate EF is a significant predictor of HRQOL during survivorship for youth previously diagnosed with a pediatric brain tumor. Results suggest that opportunities may exist to intervene and improve HRQOL of pediatric brain tumor survivors by targeting EF.

© 2021 Wiley Periodicals LLC.

Keywords: executive functioning; health-related quality of life; pediatric brain tumor; survivorship

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