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Guengerich FP, Ghodke PP. Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides. Genes Environ. 2021;43(1):24doi: 10.1186/s41021-021-00199-x.
Guengerich, F. P., & Ghodke, P. P. (2021). Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides. Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 43(1), 24. https://doi.org/10.1186/s41021-021-00199-x
Guengerich, F Peter, and Ghodke, Pratibha P. "Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides." Genes and environment : the official journal of the Japanese Environmental Mutagen Society vol. 43,1 (2021): 24. doi: https://doi.org/10.1186/s41021-021-00199-x
Guengerich FP, Ghodke PP. Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides. Genes Environ. 2021 Jun 16;43(1):24. doi: 10.1186/s41021-021-00199-x. PMID: 34130743; PMCID: PMC8207595.
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Genes Environ. 2021 Jun 16;43(1):24. doi: 10.1186/s41021-021-00199-x.

Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides.

Genes and environment : the official journal of the Japanese Environmental Mutagen Society

F Peter Guengerich, Pratibha P Ghodke

Affiliations

  1. Department of Biochemistry, Vanderbilt University School of Medicine, 638B Robinson Research Building, 2200 Pierce Avenue, Nashville, TN, 37232-0146, USA. [email protected].
  2. Department of Biochemistry, Vanderbilt University School of Medicine, 638B Robinson Research Building, 2200 Pierce Avenue, Nashville, TN, 37232-0146, USA.

PMID: 34130743 PMCID: PMC8207595 DOI: 10.1186/s41021-021-00199-x

Abstract

Etheno (and ethano) derivatives of nucleic acid bases have an extra 5-membered ring attached. These were first noted as wyosine bases in tRNAs. Some were fluorescent, and the development of etheno derivatives of adenosine, cytosine, and guanosine led to the synthesis of fluorescent analogs of ATP, NAD

Keywords: Bis-electrophiles; Chemical carcinogens; DNA adducts; Enzyme kinetics; Etheno modification; Mass spectrometry; Mutagenesis; RNA adducts; X-ray crystallography

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