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Di Castelnuovo A, Costanzo S, Bonaccio M, et al. Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study. Addiction. 2021;doi: 10.1111/add.15593.
Di Castelnuovo, A., Costanzo, S., Bonaccio, M., McElduff, P., Linneberg, A., Salomaa, V., Männistö, S., Moitry, M., Ferrières, J., Dallongeville, J., Thorand, B., Brenner, H., Ferrario, M., Veronesi, G., Pettenuzzo, E., Tamosiunas, A., Njølstad, I., Drygas, W., Nikitin, Y., Söderberg, S., Kee, F., Grassi, G., Westermann, D., Schrage, B., Dabboura, S., Zeller, T., Kuulasmaa, K., Blankenberg, S., Donati, M. B., de Gaetano, G., & Iacoviello, L. (2021). Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study. Addiction (Abingdon, England), . https://doi.org/10.1111/add.15593
Di Castelnuovo, Augusto, et al. "Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study." Addiction (Abingdon, England) vol. (2021). doi: https://doi.org/10.1111/add.15593
Di Castelnuovo A, Costanzo S, Bonaccio M, McElduff P, Linneberg A, Salomaa V, Männistö S, Moitry M, Ferrières J, Dallongeville J, Thorand B, Brenner H, Ferrario M, Veronesi G, Pettenuzzo E, Tamosiunas A, Njølstad I, Drygas W, Nikitin Y, Söderberg S, Kee F, Grassi G, Westermann D, Schrage B, Dabboura S, Zeller T, Kuulasmaa K, Blankenberg S, Donati MB, de Gaetano G, Iacoviello L. Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study. Addiction. 2021 Jun 09; doi: 10.1111/add.15593. Epub 2021 Jun 09. PMID: 34105209.
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Addiction. 2021 Jun 09; doi: 10.1111/add.15593. Epub 2021 Jun 09.

Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study.

Addiction (Abingdon, England)

Augusto Di Castelnuovo, Simona Costanzo, Marialaura Bonaccio, Patrick McElduff, Allan Linneberg, Veikko Salomaa, Satu Männistö, Marie Moitry, Jean Ferrières, Jean Dallongeville, Barbara Thorand, Hermann Brenner, Marco Ferrario, Giovanni Veronesi, Emanuela Pettenuzzo, Abdonas Tamosiunas, Inger Njølstad, Wojciech Drygas, Yuri Nikitin, Stefan Söderberg, Frank Kee, Guido Grassi, Dirk Westermann, Benedikt Schrage, Salim Dabboura, Tanja Zeller, Kari Kuulasmaa, Stefan Blankenberg, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello

Affiliations

  1. Mediterranea Cardiocentro, Napoli, Italy.
  2. Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
  3. University of Newcastle & Hunter Medical Research Institute, Australia.
  4. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  5. Finnish Institute for Health and Welfare, Helsinki, Finland.
  6. Department of Public Health, University Hospital of Strasbourg and Department of Epidemiology and Public Health, University of Strasbourg, France.
  7. Department of Cardiology and INSERM UMR 1295, Toulouse University Hospital, Toulouse, France.
  8. University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.
  9. Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany.
  10. Division of Clinical Epidemiology and Aging Research and Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany.
  11. Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy.
  12. Lithuanian University of Health Sciences, Kaunas, Lithuania.
  13. Department of community Medicine, University of Tromsø - the Arctic University of Norway, Norway.
  14. Department of Epidemiology CVD Prevention and Health Promotion, National Institute of Cardiology, Warsaw, Poland.
  15. The Institute of Internal and Preventive Medicine, Novosibirsk, Russia.
  16. Department of Public Health and Clinical Medicine, and Heart Centre, Umeå University, Sweden.
  17. Centre for Public Health, Queens University of Belfast, Belfast, Northern Ireland.
  18. Clinica Medica, Università Milano-Bicocca, Milano, Italy.
  19. Clinic of General and Interventional Cardiology, University Heart & Vascular Center Hamburg, Germany, and German Center for cardiovascular research, Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany.

PMID: 34105209 DOI: 10.1111/add.15593

Abstract

AIM: To test the association of alcohol consumption with total and cause-specific mortality risk.

DESIGN: Prospective observational multi-centre population-based study.

SETTING: Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project.

PARTICIPANTS: A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men).

MEASUREMENTS: Average alcohol intake by food frequency questionnaire, total and cause-specific mortality.

FINDINGS: In comparison with life-time abstainers, consumption of alcohol less than 10 g/day was associated with an average 11% [95% confidence interval (CI) = 7-14%] reduction in the risk of total mortality, while intake > 20 g/day was associated with a 13% (95% CI = 7-20%) increase in the risk of total mortality. Comparable findings were observed for cardiovascular (CV) deaths. With regard to cancer, drinking up to 10 g/day was not associated with either mortality risk reduction or increase, while alcohol intake > 20 g/day was associated with a 22% (95% CI = 10-35%) increased risk of mortality. The association of alcohol with fatal outcomes was similar in men and women, differed somewhat between countries and was more apparent in individuals preferring wine, suggesting that benefits may not be due to ethanol but other ingredients. Mediation analysis showed that high-density lipoprotein cholesterol explained 2.9 and 18.7% of the association between low alcohol intake and total as well as CV mortality, respectively.

CONCLUSIONS: In comparison with life-time abstainers, consuming less than one drink per day (nadir at 5 g/day) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than two drinks per day was associated with an increased risk of total, cardiovascular and especially cancer mortality.

© 2021 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.

Keywords: Alcohol intake; HDL cholesterol; cancer mortality; cardiovascular mortality; cohort study; mortality

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