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Dennis EL, Caeyenberghs K, Hoskinson KR, et al. White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury. Neurology. 2021;doi: 10.1212/WNL.0000000000012222.
Dennis, E. L., Caeyenberghs, K., Hoskinson, K. R., Merkley, T. L., Suskauer, S. J., Asarnow, R. F., Babikian, T., Bartnik-Olson, B., Bickart, K., Bigler, E. D., Ewing-Cobbs, L., Figaji, A., Giza, C. C., Goodrich-Hunsaker, N. J., Hodges, C. B., Hovenden Aa, E. S., Irimia, A., Königs, M., Levin, H. S., Lindsey, H. M., Max, J. E., Newsome, M. R., Olsen, A., Ryan, N. P., Schmidt, A. T., Spruiell, M. S., Wade, B. S., Ware, A. L., Watson, C. G., Wheeler, A. L., Yeates, K. O., Zielinski, B. A., Kochunov, P., Jahanshad, N., Thompson, P. M., Tate, D. F., & Wilde, E. A. (2021). White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury. Neurology, . https://doi.org/10.1212/WNL.0000000000012222
Dennis, Emily L, et al. "White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury." Neurology vol. (2021). doi: https://doi.org/10.1212/WNL.0000000000012222
Dennis EL, Caeyenberghs K, Hoskinson KR, Merkley TL, Suskauer SJ, Asarnow RF, Babikian T, Bartnik-Olson B, Bickart K, Bigler ED, Ewing-Cobbs L, Figaji A, Giza CC, Goodrich-Hunsaker NJ, Hodges CB, Hovenden Aa ES, Irimia A, Königs M, Levin HS, Lindsey HM, Max JE, Newsome MR, Olsen A, Ryan NP, Schmidt AT, Spruiell MS, Wade BS, Ware AL, Watson CG, Wheeler AL, Yeates KO, Zielinski BA, Kochunov P, Jahanshad N, Thompson PM, Tate DF, Wilde EA. White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury. Neurology. 2021 May 28; doi: 10.1212/WNL.0000000000012222. Epub 2021 May 28. PMID: 34050006; PMCID: PMC8302152.
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Neurology. 2021 May 28; doi: 10.1212/WNL.0000000000012222. Epub 2021 May 28.

White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury.

Neurology

Emily L Dennis, Karen Caeyenberghs, Kristen R Hoskinson, Tricia L Merkley, Stacy J Suskauer, Robert F Asarnow, Talin Babikian, Brenda Bartnik-Olson, Kevin Bickart, Erin D Bigler, Linda Ewing-Cobbs, Anthony Figaji, Christopher C Giza, Naomi J Goodrich-Hunsaker, Cooper B Hodges, Elizabeth S Hovenden Aa, Andrei Irimia, Marsh Königs, Harvey S Levin, Hannah M Lindsey, Jeffrey E Max, Mary R Newsome, Alexander Olsen, Nicholas P Ryan, Adam T Schmidt, Matthew S Spruiell, Benjamin Sc Wade, Ashley L Ware, Christopher G Watson, Anne L Wheeler, Keith Owen Yeates, Brandon A Zielinski, Peter Kochunov, Neda Jahanshad, Paul M Thompson, David F Tate, Elisabeth A Wilde

Affiliations

  1. Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT. [email protected].
  2. George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT.
  3. Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Australia.
  4. Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH.
  5. Department of Pediatrics, The Ohio State University College of Medicine.
  6. Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT.
  7. Department of Psychology, Brigham Young University, Provo, UT.
  8. Neuroscience Center, Brigham Young University, Provo, UT.
  9. Kennedy Krieger Institute, Baltimore, MD.
  10. Johns Hopkins University School of Medicine, Departments of Physical Medicine & Rehabilitation and Pediatrics, Baltimore, MD.
  11. Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA.
  12. UCLA Steve Tisch BrainSPORT Program, Los Angeles, CA.
  13. Department of Radiology, Loma Linda University Medical Center, Loma Linda, CA.
  14. Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
  15. Department of Pediatrics, Children's Learning Institute, University of Texas Health Science Center at Houston, Houston, TX.
  16. Division of Neurosurgery, University of Cape Town, Cape Town, South Africa.
  17. Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
  18. Department of Pediatrics, Division of Neurology, UCLA Mattel Children's Hospital, Los Angeles, CA.
  19. Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
  20. Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA.
  21. Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA.
  22. Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA.
  23. Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, Amsterdam, The Netherlands.
  24. H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX.
  25. Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX.
  26. Department of Psychiatry, University of California, San Diego, La Jolla, CA.
  27. Department of Psychiatry, Rady Children's Hospital, San Diego, CA.
  28. Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.
  29. Department of Physical Medicine and Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
  30. Department of Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia.
  31. Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
  32. Department of Psychological Sciences, Texas Tech University, Lubbock, TX.
  33. Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California, Los Angeles, Los Angeles, CA.
  34. Department of Psychology, University of Calgary, Alberta, Canada.
  35. Hospital for Sick Children, Neuroscience and Mental Health Program, Toronto, Canada.
  36. University of Toronto, Physiology Department, Toronto, Canada.
  37. Alberta Children's Hospital Research Institute and Hotchkiss Brain Institute, University of Calgary, Alberta, Canada.
  38. Departments of Pediatrics and Clinical Neurosciences, University of Calgary, Alberta, Canada.
  39. Departments of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT.
  40. Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD.
  41. Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA.
  42. Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, USC, Los Angeles, CA.

PMID: 34050006 PMCID: PMC8302152 DOI: 10.1212/WNL.0000000000012222

Abstract

OBJECTIVE: Our study addressed aims: (1) test the hypothesis that moderate-severe TBI in pediatric patients is associated with widespread white matter (WM) disruption; (2) test the hypothesis that age and sex impact WM organization after injury; and (3) examine associations between WM organization and neurobehavioral outcomes.

METHODS: Data from ten previously enrolled, existing cohorts recruited from local hospitals and clinics were shared with the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Pediatric msTBI working group. We conducted a coordinated analysis of diffusion MRI (dMRI) data using the ENIGMA dMRI processing pipeline.

RESULTS: Five hundred and seven children and adolescents (244 with complicated mild to severe TBI [msTBI] and 263 controls) were included. Patients were clustered into three post-injury intervals: acute/subacute - <2 months, post-acute - 2-6 months, chronic - 6+ months. Outcomes were dMRI metrics and post-injury behavioral problems as indexed by the Child Behavior Checklist (CBCL). Our analyses revealed altered WM diffusion metrics across multiple tracts and all post-injury intervals (effect sizes ranging between

CONCLUSIONS: WM disruption after msTBI is widespread, persistent, and influenced by demographic and clinical variables. Future work will test techniques for harmonizing neurocognitive data, enabling more advanced analyses to identify symptom clusters and clinically-meaningful patient subtypes.

© 2021 American Academy of Neurology.

References

  1. Front Neurol. 2017 Dec 14;8:685 - PubMed
  2. J Neuroinflammation. 2016 Apr 26;13(1):90 - PubMed
  3. J Magn Reson B. 1996 Jun;111(3):209-19 - PubMed
  4. Arch Phys Med Rehabil. 1995 Jan;76(1):17-26 - PubMed
  5. Radiology. 2002 Jan;222(1):212-8 - PubMed
  6. Child Neuropsychol. 2000 Sep;6(3):235-8 - PubMed
  7. AJNR Am J Neuroradiol. 2013 Nov-Dec;34(11):2064-74 - PubMed
  8. J Neurotrauma. 2019 Jan 15;36(2):239-249 - PubMed
  9. Front Neurol. 2018 Feb 27;9:92 - PubMed
  10. Neuroimage. 2013 Jun;73:239-54 - PubMed
  11. Front Neurol. 2019 Dec 13;10:1296 - PubMed
  12. Brain. 2011 Aug;134(Pt 8):2197-221 - PubMed
  13. Neuropsychologia. 2010 Apr;48(5):1472-82 - PubMed
  14. Int J Dev Neurosci. 2012 May;30(3):225-30 - PubMed
  15. Childs Nerv Syst. 2017 Oct;33(10):1683-1692 - PubMed
  16. Cereb Cortex. 2005 Dec;15(12):1848-54 - PubMed
  17. Neurosci Biobehav Rev. 2019 Apr;99:128-137 - PubMed
  18. Neuroimage Clin. 2019;21:101673 - PubMed
  19. Biophys J. 1994 Jan;66(1):259-67 - PubMed
  20. Heredity (Edinb). 2005 Sep;95(3):221-7 - PubMed
  21. J Head Trauma Rehabil. 2010 Jul-Aug;25(4):241-55 - PubMed
  22. Mol Psychiatry. 2019 Dec 19;: - PubMed
  23. Biomech Model Mechanobiol. 2019 Jun;18(3):631-649 - PubMed
  24. Hum Brain Mapp. 2020 Jun 1;: - PubMed
  25. Mol Psychiatry. 2018 May;23(5):1261-1269 - PubMed
  26. Hum Brain Mapp. 2010 Jul;31(7):992-1002 - PubMed
  27. Neurology. 2017 Apr 11;88(15):1392-1399 - PubMed
  28. Brain Imaging Behav. 2012 Sep;6(3):404-16 - PubMed
  29. Eur J Neurol. 2019 Sep;26(9):1183-1190 - PubMed
  30. Neuroscientist. 2018 Dec;24(6):652-670 - PubMed
  31. Neuroimage. 2013 Nov 1;81:455-469 - PubMed
  32. J Neurotrauma. 2006 Oct;23(10):1412-26 - PubMed
  33. Hum Brain Mapp. 2016 Nov;37(11):3929-3945 - PubMed
  34. Acta Biomater. 2019 Nov;99:433-442 - PubMed
  35. J Int Neuropsychol Soc. 2011 Jul;17(4):663-73 - PubMed
  36. Neuroimage. 2015 Aug 15;117:40-55 - PubMed
  37. Neuropsychology. 2015 Jul;29(4):501-8 - PubMed
  38. Brain Imaging Behav. 2021 Apr;15(2):465-474 - PubMed
  39. Brain Imaging Behav. 2021 Apr;15(2):555-575 - PubMed
  40. Hum Brain Mapp. 2020 Apr 16;: - PubMed
  41. J Neurotrauma. 2019 Jun;36(11):1738-1751 - PubMed
  42. Neurobiol Aging. 2012 Jan;33(1):9-20 - PubMed
  43. J Neuropsychiatry Clin Neurosci. 2012 Fall;24(4):427-36 - PubMed
  44. J Am Acad Child Adolesc Psychiatry. 2012 Nov;51(11):1208-17 - PubMed
  45. Brain Imaging Behav. 2018 Feb;12(1):29-43 - PubMed
  46. Transl Psychiatry. 2020 Mar 20;10(1):100 - PubMed

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