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Schwerdtfeger M, Desiderio V, Kobold S, et al. Long non-coding RNAs in cancer stem cells. Transl Oncol. 2021;14(8):101134doi: 10.1016/j.tranon.2021.101134.
Schwerdtfeger, M., Desiderio, V., Kobold, S., Regad, T., Zappavigna, S., & Caraglia, M. (2021). Long non-coding RNAs in cancer stem cells. Translational oncology, 14(8), 101134. https://doi.org/10.1016/j.tranon.2021.101134
Schwerdtfeger, Melanie, et al. "Long non-coding RNAs in cancer stem cells." Translational oncology vol. 14,8 (2021): 101134. doi: https://doi.org/10.1016/j.tranon.2021.101134
Schwerdtfeger M, Desiderio V, Kobold S, Regad T, Zappavigna S, Caraglia M. Long non-coding RNAs in cancer stem cells. Transl Oncol. 2021 Aug;14(8):101134. doi: 10.1016/j.tranon.2021.101134. Epub 2021 May 26. PMID: 34051619; PMCID: PMC8176362.
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Transl Oncol. 2021 Aug;14(8):101134. doi: 10.1016/j.tranon.2021.101134. Epub 2021 May 26.

Long non-coding RNAs in cancer stem cells.

Translational oncology

Melanie Schwerdtfeger, Vincenzo Desiderio, Sebastian Kobold, Tarik Regad, Silvia Zappavigna, Michele Caraglia

Affiliations

  1. Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy; Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Universität München, LMU Munich, Germany, Member of the German Center for Lung Research (DZL).
  2. Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
  3. Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Universität München, LMU Munich, Germany, Member of the German Center for Lung Research (DZL); German Center for Translational Cancer Research (DKTK), Partner site Munich, Munich, Germany.
  4. Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
  5. Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy. Electronic address: [email protected].

PMID: 34051619 PMCID: PMC8176362 DOI: 10.1016/j.tranon.2021.101134

Abstract

In recent years, it has been evidenced that the human transcriptome includes several types of non-coding RNAs (ncRNAs) that are mainly involved in the regulation of different cellular processes. Among ncRNAs, long-non-coding RNAs (lncRNAs) are defined as longer than 200 nucleotides and have been shown to be involved in several physiological and pathological events, including immune system regulation and cancer. Cancer stem cells (CSCs) are defined as a population of cancer cells that possess characteristics, such as resistance to standard treatments, cancer initiation, ability to undergo epithelial-to-mesenchymal transition, and the ability to invade, spread, and generate metastases. The cancer microenvironment, together with genetic and epigenetic factors, is fundamental for CSC maintenance and tumor growth and progression. Unsurprisingly, lncRNAs have been involved in both CSC biology and cancer progression, prognosis and recurrence. Here we review the most recent literature on IncRNAs involvement in CSC biology and function.

Copyright © 2021. Published by Elsevier Inc.

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